Protein: GATA3
Trans-acting T-cell-specific transcription factor GATA-3 (GATA-binding factor 3)

Gene: GATA3
Organism: Homo sapiens
Interactions: 208
UniProt ID: P23771

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

662531

RBTN1
Rhombotin-1

2

12

Small-scale

0.768

High

662644

MTA3
Metastasis-associated protein MTA3

1

20

Small-scale

0.748

High

662575

HDAC1
Histone deacetylase 1

3

15

Small-scale

0.667

High

662620

HDAC2
Histone deacetylase 2

3

15

Small-scale

0.667

High

246435

KDM1A
Lysine-specific histone demethylase 1A

3

12

Small-scale

0.660

High

188174

HDAC3
Histone deacetylase 3

2

15

Small-scale

0.641

High

662623

CBP
CREB-binding protein

2

20

Small-scale

0.634

High

662627

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

2

5

High-throughput

0.618

High

662370

GATA2
Endothelial transcription factor GATA-2

1

13

High-throughput

0.618

High

662530

RBTN2
Rhombotin-2

1

11

Small-scale

0.618

High

662668

TRPS1
Zinc finger transcription factor Trps1

1

15

High-throughput

0.618

High

395503

ESR1
Estrogen receptor

2

14

Small-scale

0.588

High

662640

CIC
Protein capicua homolog

2

18

High-throughput

0.584

High

662658

TF7L2
Transcription factor 7-like 2

2

19

Small-scale

0.584

High

662671

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

2

1

Small-scale

0.584

High

662672

RCOR1
REST corepressor 1

2

20

Small-scale

0.584

High

662590

PKHG4
Puratrophin-1

2

0

High-throughput

0.580

High

662637

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

3

Small-scale

0.579

High

473790

NFIC
Nuclear factor 1 C-type

1

18

High-throughput

0.578

High

662569

NFIA
Nuclear factor 1 A-type

1

19

High-throughput

0.578

High

662584

HIF1A
Hypoxia-inducible factor 1-alpha

1

3

Small-scale

0.578

High

662529

PSA3
Proteasome subunit alpha type-3

1

2

High-throughput

0.573

High

605168

TAL1
T-cell acute lymphocytic leukemia protein 1

2

9

Small-scale

0.571

High

662548

FOXA1
Hepatocyte nuclear factor 3-alpha

2

13

Small-scale

0.571

High

142837

NFIB
Nuclear factor 1 B-type

1

17

High-throughput

0.561

High

464814

SP1
Transcription factor Sp1

1

10

Small-scale

0.561

High

662629

FBXW7
F-box/WD repeat-containing protein 7

1

5

Small-scale

0.561

High

662673

TBX21
T-box transcription factor TBX21

1

6

Small-scale

0.554

High

70117

CRTP1
Cysteine-rich tail protein 1

2

2

High-throughput

0.553

High

662589

KR132
Keratin-associated protein 13-2

2

1

High-throughput

0.553

High

533213

RARB
Retinoic acid receptor beta

1

13

High-throughput

0.541

High

662647

TRI55
Tripartite motif-containing protein 55

1

3

High-throughput

0.541

High

172018

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

5

High-throughput

0.536

High

318446

TOX4
TOX high mobility group box family member 4

1

15

High-throughput

0.536

High

662542

NU153
Nuclear pore complex protein Nup153

1

8

High-throughput

0.536

High

662557

TOP2B
DNA topoisomerase 2-beta

1

2

High-throughput

0.536

High

662560

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

2

High-throughput

0.536

High

662585

SMU1
WD40 repeat-containing protein SMU1

1

11

High-throughput

0.536

High

662662

PK1IP
p21-activated protein kinase-interacting protein 1

1

6

High-throughput

0.536

High

439953

LCK
Tyrosine-protein kinase Lck

1

0

High-throughput

0.518

High

662677

HDAC5
Histone deacetylase 5

1

20

Small-scale

0.515

High

650054

FGFR3
Fibroblast growth factor receptor 3

1

2

High-throughput

0.515

High

662532

CLAT
Choline O-acetyltransferase

1

1

High-throughput

0.515

High

331631

MBD4
Methyl-CpG-binding domain protein 4

1

0

High-throughput

0.513

High

662603

STX12
Syntaxin-12

1

0

High-throughput

0.513

High

662612

LEMD2
LEM domain-containing protein 2

1

0

High-throughput

0.513

High

662650

ZN768
Zinc finger protein 768

1

0

High-throughput

0.513

High

662652

CBX8
Chromobox protein homolog 8

1

0

High-throughput

0.513

High

662657

RM40
Large ribosomal subunit protein mL40

1

0

High-throughput

0.513

High

662655

GCM1
Chorion-specific transcription factor GCMa

1

0

Small-scale

0.512

High

520512

RARA
Retinoic acid receptor alpha

1

13

Small-scale

0.505

High

609904

SPI1
Transcription factor PU.1

1

14

Small-scale

0.501

High

662528

CDK2
Cyclin-dependent kinase 2

1

3

Small-scale

0.501

High

662582

MK14
Mitogen-activated protein kinase 14

1

6

Small-scale

0.501

High

391568

FRIH
Ferritin heavy chain

1

1

High-throughput

0.500

High

413206

P53
Cellular tumor antigen p53

1

1

High-throughput

0.500

High

662536

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.500

High

662544

EMD
Emerin

1

2

High-throughput

0.500

High

662565

LG3BP
Galectin-3-binding protein

1

1

High-throughput

0.500

High

662581

DDB1
DNA damage-binding protein 1

1

1

High-throughput

0.500

High

662624

RAD50
DNA repair protein RAD50

1

2

High-throughput

0.500

High

662636

DCAF5
DDB1- and CUL4-associated factor 5

1

4

High-throughput

0.500

High

662653

MOV10
Helicase MOV-10

1

1

High-throughput

0.500

High

317987

TOM70
Mitochondrial import receptor subunit TOM70

1

3

High-throughput

0.489

High

661221

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

1

High-throughput

0.489

High

662669

NB5R1
NADH-cytochrome b5 reductase 1

1

1

High-throughput

0.489

High

352074

MBD3
Methyl-CpG-binding domain protein 3

1

5

Small-scale

0.484

High

662630

TRI63
E3 ubiquitin-protein ligase TRIM63

1

1

High-throughput

0.481

High

662645

REPI1
DNA-binding protein REPIN1

1

0

Small-scale

0.480

High

662543

MRE11
Double-strand break repair protein MRE11

1

0

High-throughput

0.479

High

662591

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

0

High-throughput

0.479

High

662600

PEG10
Retrotransposon-derived protein PEG10

1

0

High-throughput

0.479

High

128782

MEN1
Menin

1

1

High-throughput

0.479

High

138971

BCL9
B-cell CLL/lymphoma 9 protein

1

15

High-throughput

0.479

High

154629

ARI1A
AT-rich interactive domain-containing protein 1A

1

18

High-throughput

0.479

High

161410

KMT2D
Histone-lysine N-methyltransferase 2D

1

16

High-throughput

0.479

High

174311

ZN609
Zinc finger protein 609

1

6

High-throughput

0.479

High

177436

ZN536
Zinc finger protein 536

1

5

High-throughput

0.479

High

194511

KDM6A
Lysine-specific demethylase 6A

1

7

High-throughput

0.479

High

228967

AKAP8
A-kinase anchor protein 8

1

2

High-throughput

0.479

High

261367

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

10

High-throughput

0.479

High

278239

NCOR1
Nuclear receptor corepressor 1

1

18

High-throughput

0.479

High

280507

PR40A
Pre-mRNA-processing factor 40 homolog A

1

4

High-throughput

0.479

High

321821

PCF11
Pre-mRNA cleavage complex 2 protein Pcf11

1

3

High-throughput

0.479

High

326300

SCAF4
SR-related and CTD-associated factor 4

1

16

High-throughput

0.479

High

344867

WIZ
Protein Wiz

1

3

High-throughput

0.479

High

405801

MYCN
N-myc proto-oncogene protein

1

2

High-throughput

0.479

High

424315

IL4
Interleukin-4

1

1

Small-scale

0.479

High

442873

PRGR
Progesterone receptor

1

11

Small-scale

0.479

High

519334

MYB
Transcriptional activator Myb

1

2

Small-scale

0.479

High

519748

ANDR
Androgen receptor

1

11

Small-scale

0.479

High

586223

ZEP1
Zinc finger protein 40

1

4

High-throughput

0.479

High

606238

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

662534

BMI1
Polycomb complex protein BMI-1

1

16

Small-scale

0.479

High

662541

CEBPD
CCAAT/enhancer-binding protein delta

1

5

Small-scale

0.479

High

662545

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

20

High-throughput

0.479

High

662549

HDAC4
Histone deacetylase 4

1

20

Small-scale

0.479

High

662551

DCAF7
DDB1- and CUL4-associated factor 7

1

9

High-throughput

0.479

High

662552

SKP1
S-phase kinase-associated protein 1

1

1

High-throughput

0.479

High

662553

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.479

High

662556

SATB1
DNA-binding protein SATB1

1

4

High-throughput

0.479

High

662558

TLE1
Transducin-like enhancer protein 1

1

20

High-throughput

0.479

High

662559

TLE3
Transducin-like enhancer protein 3

1

20

High-throughput

0.479

High

662561

SUH
Recombining binding protein suppressor of hairless

1

3

High-throughput

0.479

High

662562

RING1
E3 ubiquitin-protein ligase RING1

1

18

High-throughput

0.479

High

662563

SOX4
Transcription factor SOX-4

1

20

Small-scale

0.479

High

662564

TLE5
TLE family member 5

1

10

High-throughput

0.479

High

662567

EP300
Histone acetyltransferase p300

1

20

High-throughput

0.479

High

662568

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

3

High-throughput

0.479

High

662570

FOXC1
Forkhead box protein C1

1

15

High-throughput

0.479

High

662571

TADBP
TAR DNA-binding protein 43

1

4

High-throughput

0.479

High

662574

ATR
Serine/threonine-protein kinase ATR

1

6

Small-scale

0.479

High

662576

GSE1
Genetic suppressor element 1

1

2

High-throughput

0.479

High

662579

EZH2
Histone-lysine N-methyltransferase EZH2

1

9

Small-scale

0.479

High

662580

NF2L2
Nuclear factor erythroid 2-related factor 2

1

3

Small-scale

0.479

High

662588

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

4

High-throughput

0.479

High

662593

RBM20
RNA-binding protein 20

1

4

High-throughput

0.479

High

662594

BEND3
BEN domain-containing protein 3

1

3

High-throughput

0.479

High

662596

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

15

High-throughput

0.479

High

662597

BCOR
BCL-6 corepressor

1

6

High-throughput

0.479

High

662599

PAXI1
PAX-interacting protein 1

1

7

High-throughput

0.479

High

662601

PB1
Protein polybromo-1

1

15

High-throughput

0.479

High

662602

ZFHX4
Zinc finger homeobox protein 4

1

5

High-throughput

0.479

High

662604

ARI3B
AT-rich interactive domain-containing protein 3B

1

18

High-throughput

0.479

High

662605

SUGP2
SURP and G-patch domain-containing protein 2

1

2

High-throughput

0.479

High

662606

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

1

High-throughput

0.479

High

662607

YAF2
YY1-associated factor 2

1

3

High-throughput

0.479

High

662608

RAVR1
Ribonucleoprotein PTB-binding 1

1

4

High-throughput

0.479

High

662609

RYBP
RING1 and YY1-binding protein

1

3

High-throughput

0.479

High

662610

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

3

High-throughput

0.479

High

662613

ARI1B
AT-rich interactive domain-containing protein 1B

1

20

High-throughput

0.479

High

662614

KDM2B
Lysine-specific demethylase 2B

1

2

High-throughput

0.479

High

662615

MORC4
MORC family CW-type zinc finger protein 4

1

2

High-throughput

0.479

High

662617

BCL7C
B-cell CLL/lymphoma 7 protein family member C

1

4

High-throughput

0.479

High

662618

FOG2
Zinc finger protein ZFPM2

1

11

High-throughput

0.479

High

662621

DPF1
Zinc finger protein neuro-d4

1

20

High-throughput

0.479

High

662622

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

662625

SMRC1
SWI/SNF complex subunit SMARCC1

1

14

High-throughput

0.479

High

662626

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

10

High-throughput

0.479

High

662628

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

4

High-throughput

0.479

High

662631

FUBP1
Far upstream element-binding protein 1

1

6

High-throughput

0.479

High

662632

ZBTB9
Zinc finger and BTB domain-containing protein 9

1

8

High-throughput

0.479

High

662633

ZN503
Zinc finger protein 503

1

3

High-throughput

0.479

High

662634

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

7

High-throughput

0.479

High

662635

FUBP3
Far upstream element-binding protein 3

1

6

High-throughput

0.479

High

662638

ZFR
Zinc finger RNA-binding protein

1

3

High-throughput

0.479

High

662639

QKI
KH domain-containing RNA-binding protein QKI

1

2

High-throughput

0.479

High

662641

RING2
E3 ubiquitin-protein ligase RING2

1

18

High-throughput

0.479

High

662642

ARI3A
AT-rich interactive domain-containing protein 3A

1

18

High-throughput

0.479

High

662643

PCGF1
Polycomb group RING finger protein 1

1

16

High-throughput

0.479

High

662648

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

10

High-throughput

0.479

High

662649

FOXP3
Forkhead box protein P3

1

16

Small-scale

0.479

High

662651

ZN703
Zinc finger protein 703

1

4

High-throughput

0.479

High

662656

HM20A
High mobility group protein 20A

1

19

High-throughput

0.479

High

662660

RBM12
RNA-binding protein 12

1

5

High-throughput

0.479

High

662663

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

18

High-throughput

0.479

High

662664

CPSF2
Cleavage and polyadenylation specificity factor subunit 2

1

1

High-throughput

0.479

High

662665

RCOR3
REST corepressor 3

1

20

High-throughput

0.479

High

662670

SIX4
Homeobox protein SIX4

1

7

High-throughput

0.479

High

662674

PRR12
Proline-rich protein 12

1

15

High-throughput

0.479

High

662676

SATB2
DNA-binding protein SATB2

1

4

High-throughput

0.479

High

662678

ZN281
Zinc finger protein 281

1

3

High-throughput

0.479

High

662679

NCOR2
Nuclear receptor corepressor 2

1

13

High-throughput

0.479

High

662680

NCOA3
Nuclear receptor coactivator 3

1

5

High-throughput

0.479

High

662587

KRA63
Keratin-associated protein 6-3

1

1

High-throughput

0.470

High

662533

IL13
Interleukin-13

1

0

Small-scale

0.458

High

662537

BRCA1
Breast cancer type 1 susceptibility protein

1

0

Small-scale

0.458

High

662540

CTCF
Transcriptional repressor CTCF

1

0

High-throughput

0.458

High

662547

AF17
Protein AF-17

1

0

High-throughput

0.458

High

662555

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

662595

ZN746
Zinc finger protein 746

1

0

High-throughput

0.458

High

662611

ZN709
Zinc finger protein 709

1

0

High-throughput

0.458

High

662616

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

662667

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

0

Small-scale

0.458

High

300924

RL1D1
Ribosomal L1 domain-containing protein 1

1

1

High-throughput

0.457

High

391186

FRIL
Ferritin light chain

1

1

High-throughput

0.457

High

532367

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.457

High

162471

ANM5
Protein arginine N-methyltransferase 5

1

1

Small-scale

0.445

High

245589

ZEB2
Zinc finger E-box-binding homeobox 2

1

3

Small-scale

0.445

High

370565

FOS
Protein c-Fos

1

1

Small-scale

0.445

High

461162

HS90A
Heat shock protein HSP 90-alpha

1

3

Small-scale

0.445

High

565507

RARG
Retinoic acid receptor gamma

1

13

Small-scale

0.445

High

605557

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

3

Small-scale

0.445

High

662538

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

3

Small-scale

0.445

High

662546

KIF11
Kinesin-like protein KIF11

1

1

Small-scale

0.445

High

662566

RBBP4
Histone-binding protein RBBP4

1

5

Small-scale

0.445

High

662577

STK38
Serine/threonine-protein kinase 38

1

3

Small-scale

0.445

High

662619

AP2C
Transcription factor AP-2 gamma

1

1

Small-scale

0.445

High

662592

PRC2B
Protein PRRC2B

1

13

High-throughput

0.437

High

662654

FBSL
Fibrosin-1-like protein

1

3

High-throughput

0.437

High

662578

JHD2C
Probable JmjC domain-containing histone demethylation protein 2C

1

0

Small-scale

0.426

High

662598

UBR3
E3 ubiquitin-protein ligase UBR3

1

0

Small-scale

0.426

High

662661

SDA1
Protein SDA1 homolog

1

0

Small-scale

0.426

High

662550

KR121
Keratin-associated protein 12-1

2

0

High-throughput

0.316

High

662586

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.316

High

662535

ACTN2
Alpha-actinin-2

1

0

High-throughput

0.299

High

662554

RT05
Small ribosomal subunit protein uS5m

1

0

High-throughput

0.279

Low

662573

NNTM
NAD(P) transhydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

662583

FSCN1
Fascin

1

0

High-throughput

0.279

Low

662646

RM09
Large ribosomal subunit protein bL9m

1

0

High-throughput

0.279

Low

662659

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

High-throughput

0.279

Low

662666

ATX10
Ataxin-10

1

0

High-throughput

0.261

Low

469759

SODE
Extracellular superoxide dismutase [Cu-Zn]

1

0

Small-scale

0.249

Low

662539

RL34
Large ribosomal subunit protein eL34

1

0

High-throughput

0.249

Low

243891

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

0

Small-scale

0.232

Low

399545

VTNC
Vitronectin

1

0

Small-scale

0.232

Low

662572

MMRN1
Multimerin-1

1

0

Small-scale

0.232

Low

662675

LORF1
LINE-1 retrotransposable element ORF1 protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025