HitPredict

Interactor 1: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Interactor 2: CDC20 (Q12834)
Cell division cycle protein 20 homolog (p55CDC)
Gene: CDC20

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.733

Property	Details
Experiments	26811472, 28514442, 33961781, 25852190, 36736316, 23455922
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005813 - centrosome GO:0005829 - cytosol GO:0007346 - regulation of mitotic cell cycle GO:0051301 - cell division
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 298 Hs			1 499
+	Hs
		414894 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		CDC20_HUMAN (1-499): 1.18e-136: 405: 100.00
+	Hs
		625543 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		FBXW7_HUMAN (210-496): 2.2e-71: 242: 17.81
+	Hs
		415016 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		FBXW7_HUMAN (210-496): 2.2e-71: 242: 17.81
+	Hs
		625202 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		LIS1_HUMAN (337-498): 1.74e-37: 143: 16.56
+	Hs
		625637 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		FZR1_HUMAN (315-495): 1.51e-24: 108: 19.02
+	Hs
		414806 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		LIS1_HUMAN (337-498): 1.74e-37: 143: 16.56
+	Sc
		565470 PHO85_YEAST (3-290): 6.29e-131: 375: 54.88		NLE1_YEAST (63-336): 4.61e-43: 161: 17.34
+	Sc
		339740 CDK1_YEAST (1-288): 3.57e-132: 378: 62.12		AMA1_YEAST (162-470): 1.12e-38: 150: 28.65
+	Hs
		415103 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		FZR1_HUMAN (315-495): 1.51e-24: 108: 19.02
+	At
		621673 CDKA1_ARATH (1-289): 1.02e-144: 410: 68.62		FZR2_ARATH (315-495): 1.1e-20: 96.6: 18.03
+	Hs
		960344 CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39		FZR1_HUMAN (315-495): 1.51e-24: 108: 19.02
+	At
		621683 CDKA1_ARATH (1-289): 1.02e-144: 410: 68.62		FZR1_ARATH (315-495): 5.69e-19: 91.6: 20.22
+	At
		621679 CDKA1_ARATH (1-289): 1.02e-144: 410: 68.62		FZR3_ARATH (313-495): 2.14e-18: 89.6: 17.30
+	Sc
		339758 CDK1_YEAST (1-288): 3.57e-132: 378: 62.12		CDH1_YEAST (315-495): 4.18e-17: 86.2: 12.57
+	Dm
		618423 CDK1_DROME (1-289): 1.85e-139: 396: 63.45		Q9W4H9_DROME (395-496): 6.69e-10: 63: 15.39
+	Sc
		339473 CDK1_YEAST (1-288): 3.57e-132: 378: 62.12		CDC20_YEAST (315-495): 5.18e-14: 76.6: 18.13
+	Hs
		841208 CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00		TAF5_HUMAN (239-336): 9.1e-10: 63.2: 37.00