HitPredict

Interactor 1: RBBP4 (Q09028)
Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48)
Gene: RBBP4

Interactor 2: SHPRH (Q149N8)
E3 ubiquitin-protein ligase SHPRH (EC 2.3.2.27) (EC 3.6.4.-) (RING-type E3 ubiquitin transferase SHPRH) (SNF2, histone-linker, PHD and RING finger domain-containing helicase)
Gene: SHPRH

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	24981860, 33961781, 35271311, 37689310
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0006334 - nucleosome assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 425 Hs			1 1683
+	Hs
		1061757 RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20		SHPRH_HUMAN (1-1683): 0: 1247: 100.00
+	Hs
		997824 RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00		CHD5_HUMAN (1253-1682): 1.55e-104: 373: 17.96
+	Hs
		229377 RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00		SMCA5_HUMAN (1267-1682): 2.48e-107: 370: 15.44
+	Hs
		997695 RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00		CHD3_HUMAN (1279-1682): 6.88e-103: 368: 17.87
+	Hs
		1083322 RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20		CHD5_HUMAN (1253-1682): 1.55e-104: 373: 17.96
+	Hs
		229413 RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20		SMCA5_HUMAN (1267-1682): 2.48e-107: 370: 15.44
+	Hs
		997936 RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00		CHD7_HUMAN (1187-1679): 3.9e-96: 348: 13.11
+	Hs
		1018507 RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20		CHD3_HUMAN (1279-1682): 6.88e-103: 368: 17.87
+	Hs
		846946 RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00		SMCA4_HUMAN (1246-1682): 3.38e-96: 346: 13.91
+	Hs
		997726 RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00		CHD4_HUMAN (1275-1682): 1.8e-95: 345: 17.70
+	Hs
		846759 RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00		SMCA2_HUMAN (1161-1676): 4.99e-95: 342: 13.08
+	Hs
		1059641 RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20		CHD4_HUMAN (1275-1682): 1.8e-95: 345: 17.70
+	Hs
		846786 RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20		SMCA2_HUMAN (1161-1676): 4.99e-95: 342: 13.08
+	Hs
		658658 RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00		SMCA1_HUMAN (1315-1682): 8.95e-71: 261: 16.12
+	Hs
		658682 RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20		SMCA1_HUMAN (1315-1682): 8.95e-71: 261: 16.12
+	Hs
		903234 WDR5_HUMAN (267-425): 7.48e-35: 133: 25.61		CHD4_HUMAN (1275-1682): 1.8e-95: 345: 17.70
+	Hs
		903535 WDR5_HUMAN (267-425): 7.48e-35: 133: 25.61		CHD8_HUMAN (1145-1679): 9.94e-95: 343: 13.11
+	Dm
		332768 CAF1_DROME (226-419): 3.68e-29: 119: 18.36		CHDM_DROME (1255-1682): 1.2e-97: 352: 15.95
+	Hs
		1059830 GRWD1_HUMAN (263-425): 3.54e-26: 111: 23.56		CHD4_HUMAN (1275-1682): 1.8e-95: 345: 17.70
+	Ce
		104626 LIN53_CAEEL (272-421): 6.33e-22: 99.1: 21.52		LE418_CAEEL (1276-1682): 1.32e-98: 354: 16.75