HitPredict

Interactor 1: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Interactor 2: SPDE1 (Q8NFV5)
Speedy protein E1 (Williams-Beuren syndrome chromosomal region 19 protein)
Gene: SPDYE1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	15574121
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Spy1
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 298 Hs			1 336
+	Hs
		414999 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		SPDE1_HUMAN (1-336): 0: 554: 100.00
+	Hs
		960311 CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39		SPDE1_HUMAN (1-336): 0: 554: 100.00
+	Hs
		625484 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		SPDYC_HUMAN (153-332): 6.24e-54: 179: 32.60
+	Hs
		625485 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		SPDYA_HUMAN (116-333): 9.7e-49: 167: 27.48
+	Xl
		724514 CDK1A_XENLA (1-291): 1.26e-143: 407: 67.12		SPD1A_XENLA (119-332): 6.46e-62: 201: 33.95
+	Xl
		621606 CDK1B_XENLA (1-291): 1.1e-142: 405: 66.78		SPD1A_XENLA (119-332): 6.46e-62: 201: 33.95
+	Hs
		414951 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		SPDYC_HUMAN (153-332): 6.24e-54: 179: 32.60
+	Hs
		414952 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		SPDYA_HUMAN (116-333): 9.7e-49: 167: 27.48
+	Hs
		63992 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		SPDE4_HUMAN (13-110): 1.64e-23: 98.8: 57.84
+	Hs
		960292 CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39		SPDYA_HUMAN (116-333): 9.7e-49: 167: 27.48
+	Hs
		625476 CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00		SPDE7_HUMAN (33-110): 1.34e-21: 93: 53.66
+	Hs
		64006 CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87		SPDE4_HUMAN (13-110): 1.64e-23: 98.8: 57.84
+	Hs
		63987 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		SPDE4_HUMAN (13-110): 1.64e-23: 98.8: 57.84
+	Hs
		414944 CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90		SPDE7_HUMAN (33-110): 1.34e-21: 93: 53.66
+	Hs
		64007 CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39		SPDE4_HUMAN (13-110): 1.64e-23: 98.8: 57.84
+	Hs
		960374 CDK16_HUMAN (1-286): 4.1e-107: 322: 55.40		SPDYA_HUMAN (116-333): 9.7e-49: 167: 27.48
+	Hs
		64008 CDK16_HUMAN (1-286): 4.1e-107: 322: 55.40		SPDE4_HUMAN (13-110): 1.64e-23: 98.8: 57.84