HitPredict

Interactor 1: CXCR2 (P25025)
C-X-C chemokine receptor type 2 (CXC-R2) (CXCR-2) (CDw128b) (GRO/MGSA receptor) (High affinity interleukin-8 receptor B) (IL-8R B) (IL-8 receptor type 2) (CD antigen CD182)
Gene: CXCR2

Interactor 2: CXCL6 (P80162)
C-X-C motif chemokine 6 (Chemokine alpha 3) (CKA-3) (Granulocyte chemotactic protein 2) (GCP-2) (Small-inducible cytokine B6) [Cleaved into: Small-inducible cytokine B6, N-processed variant 1; Small-inducible cytokine B6, N-processed variant 2; Small-inducible cytokine B6, N-processed variant 3]
Gene: CXCL6

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	9485196
Identification Methods	competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006935 - chemotaxis GO:0006954 - inflammatory response GO:0007165 - signal transduction GO:0030593 - neutrophil chemotaxis GO:0042119 - neutrophil activation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 360 Hs			1 114
+	Hs
		625748 CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00		CXCL5_HUMAN (1-114): 6.11e-39: 127: 79.83
+	Hs
		364042 CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00		CXCL7_HUMAN (36-114): 3.87e-28: 100: 40.51
+	Hs
		587767 CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00		CXCL2_HUMAN (38-112): 2.26e-27: 98.6: 40.00
+	Hs
		587786 CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00		CXCL3_HUMAN (43-112): 1.33e-26: 96.7: 45.71
+	Hs
		448988 CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00		GROA_HUMAN (43-112): 2.47e-26: 95.9: 45.71
+	Hs
		486185 CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00		IL8_HUMAN (34-113): 1.04e-25: 94: 29.63
+	Hs
		625736 CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92		CXCL5_HUMAN (1-114): 6.11e-39: 127: 79.83
+	Mm
		500672 CXCR2_MOUSE (1-348): 2e-78: 246: 70.69		CXCL2_MOUSE (38-112): 1.64e-28: 101: 50.67
+	Mm
		522397 CXCR2_MOUSE (1-348): 2e-78: 246: 70.69		GROA_MOUSE (39-109): 1.59e-27: 98.6: 45.07
+	Hs
		364080 CXCR3_HUMAN (21-357): 3.8e-79: 248: 40.71		PLF4_HUMAN (34-109): 1.79e-25: 93.6: 40.79
+	Hs
		217751 CXCR3_HUMAN (21-357): 3.8e-79: 248: 40.71		CXL13_HUMAN (38-112): 1.11e-22: 86.7: 26.32
+	Hs
		849615 CCR3_HUMAN (50-358): 1.44e-79: 249: 33.65		CXCL9_HUMAN (39-105): 1.1e-19: 79.3: 32.35
+	Hs
		830623 CXCR3_HUMAN (21-357): 3.8e-79: 248: 40.71		CXCL9_HUMAN (39-105): 1.1e-19: 79.3: 32.35
+	Hs
		150319 CCR3_HUMAN (50-358): 1.44e-79: 249: 33.65		CXL11_HUMAN (35-109): 1.42e-19: 78.2: 25.97
+	Hs
		364107 CCR3_HUMAN (50-358): 1.44e-79: 249: 33.65		CXL10_HUMAN (36-114): 3.6e-19: 77.4: 29.63
+	Hs
		150317 CXCR3_HUMAN (21-357): 3.8e-79: 248: 40.71		CXL11_HUMAN (35-109): 1.42e-19: 78.2: 25.97
+	Hs
		364105 CXCR3_HUMAN (21-357): 3.8e-79: 248: 40.71		CXL10_HUMAN (36-114): 3.6e-19: 77.4: 29.63
+	Hs
		364041 CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92		CXCL7_HUMAN (36-114): 3.87e-28: 100: 40.51
+	Hs
		448987 CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92		GROA_HUMAN (43-112): 2.47e-26: 95.9: 45.71
+	Hs
		486184 CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92		IL8_HUMAN (34-113): 1.04e-25: 94: 29.63