Protein: TBP
TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit)

Gene: TBP
Organism: Homo sapiens
Interactions: 236
UniProt ID: P20226

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000791 - euchromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

628696

TAF1
Transcription initiation factor TFIID subunit 1

19

14

Small-scale

0.986

High

628732

TF2AA
Transcription initiation factor IIA subunit 1

14

10

Small-scale

0.983

High

628785

TAF11
Transcription initiation factor TFIID subunit 11

9

2

Small-scale

0.971

High

628825

TF3B
Transcription factor IIIB 90 kDa subunit

8

13

Small-scale

0.971

High

130699

TAF4
Transcription initiation factor TFIID subunit 4

10

4

Small-scale

0.970

High

628747

TF2B
Transcription initiation factor IIB

8

13

Small-scale

0.964

High

628733

T2AG
Transcription initiation factor IIA subunit 2

6

4

Small-scale

0.946

High

628754

NC2B
Protein Dr1

5

4

Small-scale

0.917

High

628781

NC2A
Dr1-associated corepressor

4

2

Small-scale

0.886

High

628784

TAF13
Transcription initiation factor TFIID subunit 13

3

3

Small-scale

0.877

High

173651

BTAF1
TATA-binding protein-associated factor 172

3

6

Small-scale

0.873

High

628844

BRF2
Transcription factor IIIB 50 kDa subunit

3

13

Small-scale

0.847

High

628692

TBP
TATA-box-binding protein

3

4

Small-scale

0.817

High

628820

TAF4B
Transcription initiation factor TFIID subunit 4B

2

4

Small-scale

0.789

High

628814

TAF1L
Transcription initiation factor TFIID subunit 1-like

2

15

Small-scale

0.775

High

628783

TAF5
Transcription initiation factor TFIID subunit 5

16

8

Small-scale

0.760

High

628728

TAF6
Transcription initiation factor TFIID subunit 6

13

6

Small-scale

0.757

High

628794

TAF12
Transcription initiation factor TFIID subunit 12

9

2

Small-scale

0.755

High

628768

TAF10
Transcription initiation factor TFIID subunit 10

13

6

Small-scale

0.755

High

413173

P53
Cellular tumor antigen p53

10

1

Small-scale

0.754

High

628786

TAF7
Transcription initiation factor TFIID subunit 7

9

5

Small-scale

0.747

High

628788

TAF1A
TATA box-binding protein-associated factor RNA polymerase I subunit A

6

1

Small-scale

0.737

High

628797

TAF9
Transcription initiation factor TFIID subunit 9

6

3

Small-scale

0.724

High

628700

NFYB
Nuclear transcription factor Y subunit beta

1

4

Small-scale

0.724

High

628787

TAF1C
TATA box-binding protein-associated factor RNA polymerase I subunit C

5

1

Small-scale

0.718

High

628811

TAF8
Transcription initiation factor TFIID subunit 8

5

6

Small-scale

0.716

High

628800

TAF1B
TATA box-binding protein-associated factor RNA polymerase I subunit B

4

1

Small-scale

0.702

High

628699

RPB1
DNA-directed RNA polymerase II subunit RPB1

4

4

Small-scale

0.698

High

628842

CUED2
CUE domain-containing protein 2

4

1

High-throughput

0.695

High

628790

IKBB
NF-kappa-B inhibitor beta

4

2

High-throughput

0.694

High

64423

BDP1
Transcription factor TFIIIB component B'' homolog

1

2

High-throughput

0.691

High

628830

LRC46
Leucine-rich repeat-containing protein 46

4

1

High-throughput

0.691

High

628803

TAF3
Transcription initiation factor TFIID subunit 3

4

4

Small-scale

0.689

High

395479

ESR1
Estrogen receptor

4

7

Small-scale

0.680

High

628751

E2F1
Transcription factor E2F1

3

1

Small-scale

0.678

High

628701

BRD2
Bromodomain-containing protein 2

3

7

Small-scale

0.674

High

628808

TAF2
Transcription initiation factor TFIID subunit 2

4

2

Small-scale

0.672

High

628717

T2FA
General transcription factor IIF subunit 1

4

0

Small-scale

0.671

High

370558

FOS
Protein c-Fos

3

2

Small-scale

0.670

High

628843

TAF1D
TATA box-binding protein-associated factor RNA polymerase I subunit D

4

0

Small-scale

0.670

High

628737

PSME3
Proteasome activator complex subunit 3

3

1

High-throughput

0.669

High

258423

EDF1
Endothelial differentiation-related factor 1

3

2

Small-scale

0.663

High

628707

MSX1
Homeobox protein MSX-1

3

1

Small-scale

0.651

High

628760

TF65
Transcription factor p65

3

1

Small-scale

0.651

High

569052

T2FB
General transcription factor IIF subunit 2

1

1

Small-scale

0.647

High

628859

TF2AY
TFIIA-alpha and beta-like factor

1

10

Small-scale

0.647

High

628697

TCEA1
Transcription elongation factor A protein 1

3

2

Small-scale

0.646

High

628708

T2EA
General transcription factor IIE subunit 1

3

0

Small-scale

0.639

High

609898

SPI1
Transcription factor PU.1

2

5

Small-scale

0.634

High

481087

HMGB1
High mobility group protein B1

2

1

Small-scale

0.629

High

628720

ZNF76
Zinc finger protein 76

2

1

Small-scale

0.620

High

628840

RPC6
DNA-directed RNA polymerase III subunit RPC6

2

1

Small-scale

0.619

High

628740

TBPL1
TATA box-binding protein-like 1

1

4

High-throughput

0.618

High

628750

MDM2
E3 ubiquitin-protein ligase Mdm2

2

1

Small-scale

0.613

High

628774

SNPC2
snRNA-activating protein complex subunit 2

2

0

Small-scale

0.612

High

429288

JUN
Transcription factor Jun

2

1

Small-scale

0.611

High

628801

TAF7L
Transcription initiation factor TFIID subunit 7-like

2

5

Small-scale

0.611

High

628838

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

1

Small-scale

0.611

High

628845

TAF9B
Transcription initiation factor TFIID subunit 9B

2

3

Small-scale

0.611

High

628793

NF2L2
Nuclear factor erythroid 2-related factor 2

1

1

Small-scale

0.603

High

628718

AHR
Aryl hydrocarbon receptor

2

1

Small-scale

0.602

High

464803

SP1
Transcription factor Sp1

2

1

Small-scale

0.594

High

478902

PO2F2
POU domain, class 2, transcription factor 2

1

3

Small-scale

0.589

High

576160

PO2F1
POU domain, class 2, transcription factor 1

1

4

Small-scale

0.589

High

628709

T2EB
Transcription initiation factor IIE subunit beta

2

0

Small-scale

0.577

High

628823

RBP56
TATA-binding protein-associated factor 2N

2

1

Small-scale

0.571

High

577610

PLAK
Junction plakoglobin

1

2

Small-scale

0.561

High

628703

PAX6
Paired box protein Pax-6

1

3

Small-scale

0.561

High

628757

PAX5
Paired box protein Pax-5

1

3

Small-scale

0.561

High

628795

SNPC1
snRNA-activating protein complex subunit 1

1

1

Small-scale

0.561

High

628857

YETS2
YEATS domain-containing protein 2

1

2

Small-scale

0.561

High

628738

WDR5
WD repeat-containing protein 5

2

0

Small-scale

0.559

High

628693

PO3F2
POU domain, class 3, transcription factor 2

1

3

Small-scale

0.552

High

628782

CND2
Condensin complex subunit 2

1

1

Small-scale

0.552

High

628821

TF2H4
General transcription factor IIH subunit 4

1

1

Small-scale

0.550

High

628752

SET
Protein SET

1

1

Small-scale

0.546

High

214541

WDR62
WD repeat-containing protein 62

1

1

High-throughput

0.541

High

628769

REST
RE1-silencing transcription factor

1

0

Small-scale

0.537

High

165008

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

4

High-throughput

0.536

High

180233

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

3

High-throughput

0.536

High

186833

FOXN1
Forkhead box protein N1

1

3

High-throughput

0.536

High

284796

TADA3
Transcriptional adapter 3

1

1

High-throughput

0.536

High

284926

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

1

8

High-throughput

0.536

High

287437

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

1

High-throughput

0.536

High

391180

FRIL
Ferritin light chain

1

2

High-throughput

0.536

High

430605

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

1

High-throughput

0.536

High

608445

DDX5
Probable ATP-dependent RNA helicase DDX5

1

1

Small-scale

0.536

High

621810

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

2

High-throughput

0.536

High

625190

CSK22
Casein kinase II subunit alpha'

1

1

High-throughput

0.536

High

628702

MOES
Moesin

1

1

High-throughput

0.536

High

628712

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

4

High-throughput

0.536

High

628734

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

1

High-throughput

0.536

High

628736

MAX
Protein max

1

2

High-throughput

0.536

High

628741

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

1

High-throughput

0.536

High

628753

FOXK2
Forkhead box protein K2

1

2

High-throughput

0.536

High

628762

SUH
Recombining binding protein suppressor of hairless

1

1

High-throughput

0.536

High

628770

TADBP
TAR DNA-binding protein 43

1

1

High-throughput

0.536

High

628771

MK07
Mitogen-activated protein kinase 7

1

1

High-throughput

0.536

High

628824

FOXJ1
Forkhead box protein J1

1

3

High-throughput

0.536

High

628837

SPT25
Spermatogenesis-associated protein 25

1

1

High-throughput

0.536

High

628841

FOXP1
Forkhead box protein P1

1

5

High-throughput

0.536

High

628848

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

4

High-throughput

0.536

High

628851

FOXJ2
Forkhead box protein J2

1

3

High-throughput

0.536

High

628865

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

1

High-throughput

0.536

High

628764

GOGA2
Golgin subfamily A member 2

2

1

High-throughput

0.533

High

625758

RXRA
Retinoic acid receptor RXR-alpha

1

3

Small-scale

0.527

High

563173

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

421479

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.515

High

186362

RPC7
DNA-directed RNA polymerase III subunit RPC7

1

0

High-throughput

0.513

High

192786

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

High-throughput

0.513

High

319136

ST65G
STAGA complex 65 subunit gamma

1

0

High-throughput

0.513

High

335954

MED26
Mediator of RNA polymerase II transcription subunit 26

1

0

High-throughput

0.513

High

561105

GILT
Gamma-interferon-inducible lysosomal thiol reductase

1

0

High-throughput

0.513

High

628704

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.513

High

628724

MAGA9
Melanoma-associated antigen 9

1

0

High-throughput

0.513

High

628729

VASP
Vasodilator-stimulated phosphoprotein

1

0

High-throughput

0.513

High

628731

MAT1
CDK-activating kinase assembly factor MAT1

1

0

High-throughput

0.513

High

628776

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.513

High

628806

IFIX
Pyrin and HIN domain-containing protein 1

1

0

High-throughput

0.513

High

628809

AAGAB
Alpha- and gamma-adaptin-binding protein p34

1

0

High-throughput

0.513

High

628813

RN168
E3 ubiquitin-protein ligase RNF168

1

0

High-throughput

0.513

High

628829

TADA1
Transcriptional adapter 1

1

0

High-throughput

0.513

High

628831

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.513

High

628832

PPM1M
Protein phosphatase 1M

1

0

High-throughput

0.513

High

628839

PIP30
PSME3-interacting protein

1

0

High-throughput

0.513

High

628847

TF7L2
Transcription factor 7-like 2

1

0

High-throughput

0.513

High

628855

DBR1
Lariat debranching enzyme

1

0

High-throughput

0.513

High

628852

CXXC1
CXXC-type zinc finger protein 1

1

1

High-throughput

0.508

High

371143

MYC
Myc proto-oncogene protein

1

2

Small-scale

0.501

High

403813

GCR
Glucocorticoid receptor

1

8

Small-scale

0.501

High

442870

PRGR
Progesterone receptor

1

7

Small-scale

0.501

High

519732

ANDR
Androgen receptor

1

7

Small-scale

0.501

High

577406

ETS1
Protein C-ets-1

1

3

Small-scale

0.501

High

628695

BCL3
B-cell lymphoma 3 protein

1

2

Small-scale

0.501

High

628698

PAX3
Paired box protein Pax-3

1

3

Small-scale

0.501

High

628723

HNF4A
Hepatocyte nuclear factor 4-alpha

1

3

Small-scale

0.501

High

628746

ELF3
ETS-related transcription factor Elf-3

1

5

Small-scale

0.501

High

628749

HSF1
Heat shock factor protein 1

1

3

Small-scale

0.501

High

628755

SPIB
Transcription factor Spi-B

1

5

Small-scale

0.501

High

628761

REL
Proto-oncogene c-Rel

1

1

Small-scale

0.501

High

628767

FOXF2
Forkhead box protein F2

1

2

Small-scale

0.501

High

628777

KLF5
Krueppel-like factor 5

1

2

Small-scale

0.501

High

628778

NFYC
Nuclear transcription factor Y subunit gamma

1

2

Small-scale

0.501

High

628779

NCOA6
Nuclear receptor coactivator 6

1

1

Small-scale

0.501

High

628792

NCOA1
Nuclear receptor coactivator 1

1

1

Small-scale

0.501

High

628861

RUVB2
RuvB-like 2

1

5

Small-scale

0.501

High

628862

RUVB1
RuvB-like 1

1

5

Small-scale

0.501

High

628748

CDK5
Cyclin-dependent kinase 5

1

0

High-throughput

0.493

High

239010

ZNRD2
Protein ZNRD2

1

1

High-throughput

0.489

High

505642

DC8L2
DDB1- and CUL4-associated factor 8-like protein 2

1

1

High-throughput

0.489

High

628868

EMIL1
EMILIN-1

1

1

High-throughput

0.489

High

628735

HAP1
Huntingtin-associated protein 1

1

0

High-throughput

0.486

High

628807

HMBX1
Homeobox-containing protein 1

1

5

High-throughput

0.481

High

628863

ADIP
Afadin- and alpha-actinin-binding protein

1

1

High-throughput

0.481

High

442583

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.480

High

617197

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

0

Small-scale

0.480

High

628706

TEAD1
Transcriptional enhancer factor TEF-1

1

0

Small-scale

0.480

High

628710

KDM5A
Lysine-specific demethylase 5A

1

0

Small-scale

0.480

High

628727

MCM2
DNA replication licensing factor MCM2

1

0

Small-scale

0.480

High

628743

UBC9
SUMO-conjugating enzyme UBC9

1

0

Small-scale

0.480

High

628745

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

Small-scale

0.480

High

628758

CREM
cAMP-responsive element modulator

1

0

Small-scale

0.480

High

628772

CTBP1
C-terminal-binding protein 1

1

0

Small-scale

0.480

High

628773

IKZF1
DNA-binding protein Ikaros

1

0

Small-scale

0.480

High

628802

SNPC4
snRNA-activating protein complex subunit 4

1

0

Small-scale

0.480

High

628810

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

Small-scale

0.480

High

628815

CTCFL
Transcriptional repressor CTCFL

1

0

Small-scale

0.480

High

628818

TF3C2
General transcription factor 3C polypeptide 2

1

0

Small-scale

0.480

High

628834

HTF4
Transcription factor 12

1

0

Small-scale

0.480

High

628836

CITE2
Cbp/p300-interacting transactivator 2

1

0

Small-scale

0.480

High

628853

MBD2
Methyl-CpG-binding domain protein 2

1

0

Small-scale

0.480

High

628856

TF3C4
General transcription factor 3C polypeptide 4

1

0

Small-scale

0.480

High

628866

TF3C5
General transcription factor 3C polypeptide 5

1

0

Small-scale

0.480

High

628867

TF3C3
General transcription factor 3C polypeptide 3

1

0

Small-scale

0.480

High

240730

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

315106

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

604592

UBF1
Nucleolar transcription factor 1

1

1

Small-scale

0.479

High

628713

ELF1
ETS-related transcription factor Elf-1

1

3

High-throughput

0.479

High

628716

MERL
Merlin

1

1

High-throughput

0.479

High

628719

PRS7
26S proteasome regulatory subunit 7

1

4

Small-scale

0.479

High

628725

CBX5
Chromobox protein homolog 5

1

1

Small-scale

0.479

High

628730

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

3

Small-scale

0.479

High

628739

1433E
14-3-3 protein epsilon

1

1

Small-scale

0.479

High

628742

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

3

Small-scale

0.479

High

628744

H31
Histone H3.1

1

2

High-throughput

0.479

High

628756

MEF2A
Myocyte-specific enhancer factor 2A

1

1

Small-scale

0.479

High

628765

EP300
Histone acetyltransferase p300

1

5

Small-scale

0.479

High

628775

HDAC1
Histone deacetylase 1

1

1

Small-scale

0.479

High

628780

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

1

Small-scale

0.479

High

628789

MED1
Mediator of RNA polymerase II transcription subunit 1

1

1

Small-scale

0.479

High

628791

ELF2
ETS-related transcription factor Elf-2

1

3

High-throughput

0.479

High

628822

CBP
CREB-binding protein

1

5

Small-scale

0.479

High

628858

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

628860

TRI33
E3 ubiquitin-protein ligase TRIM33

1

1

High-throughput

0.479

High

628827

COQA1
Collagen alpha-1(XXVI) chain

1

1

High-throughput

0.464

High

184685

ATX7
Ataxin-7

1

0

Small-scale

0.458

High

190816

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

Small-scale

0.458

High

378546

IL1B
Interleukin-1 beta

1

0

Small-scale

0.458

High

464357

ERCC1
DNA excision repair protein ERCC-1

1

0

Small-scale

0.458

High

469255

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

0

Small-scale

0.458

High

486948

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

533877

IRF1
Interferon regulatory factor 1

1

0

Small-scale

0.458

High

628694

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

628705

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.458

High

628711

CDC27
Cell division cycle protein 27 homolog

1

0

Small-scale

0.458

High

628714

C2TA
MHC class II transactivator

1

0

Small-scale

0.458

High

628722

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

628726

CDX1
Homeobox protein CDX-1

1

0

Small-scale

0.458

High

628759

KMT2A
Histone-lysine N-methyltransferase 2A

1

0

Small-scale

0.458

High

628763

DHX9
ATP-dependent RNA helicase A

1

0

Small-scale

0.458

High

628766

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

0

Small-scale

0.458

High

628796

B2LA1
Bcl-2-related protein A1

1

0

Small-scale

0.458

High

628804

ICE2
Little elongation complex subunit 2

1

0

High-throughput

0.458

High

628812

MKX
Homeobox protein Mohawk

1

0

Small-scale

0.458

High

628816

SETD7
Histone-lysine N-methyltransferase SETD7

1

0

Small-scale

0.458

High

628833

SIN3A
Paired amphipathic helix protein Sin3a

1

0

Small-scale

0.458

High

628835

EYA3
Protein phosphatase EYA3

1

0

High-throughput

0.458

High

628850

RRN3
RNA polymerase I-specific transcription initiation factor RRN3

1

0

Small-scale

0.458

High

289212

CREG1
Protein CREG1

1

1

Small-scale

0.457

High

628715

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

628805

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.445

High

628846

CBX8
Chromobox protein homolog 8

1

2

Small-scale

0.445

High

378361

IFNB
Interferon beta

1

1

Small-scale

0.437

High

628798

H31T
Histone H3.1t

1

2

High-throughput

0.408

High

628826

FATE1
Fetal and adult testis-expressed transcript protein

1

0

High-throughput

0.282

High

260834

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

380257

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

0

High-throughput

0.279

Low

628817

NPRL2
GATOR1 complex protein NPRL2

1

0

High-throughput

0.279

Low

628819

OIT3
Oncoprotein-induced transcript 3 protein

1

0

High-throughput

0.279

Low

628828

K1143
Uncharacterized protein KIAA1143

1

0

High-throughput

0.279

Low

628849

CUED1
CUE domain-containing protein 1

1

0

High-throughput

0.279

Low

628721

SPB5
Serpin B5

1

0

Small-scale

0.251

Low

628799

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

628854

GBG12

1

0

Small-scale

0.249

Low

628864

TMED7
Transmembrane emp24 domain-containing protein 7

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025