HitPredict

Interactor 1: ARBK1 (P25098)
Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2)
Gene: GRK2

Interactor 2: ARBK2 (P35626)
G protein-coupled receptor kinase 3 (EC 2.7.11.15) (Beta-adrenergic receptor kinase 2) (Beta-ARK-2)
Gene: GRK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.861

The method score is based on:

Property Details
Experiments 28514442, 33961781, 23455922
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PH~PH, PH~Pkinase, Pkinase~Pkinase, Pkinase~RGS, RGS~RGS
Common GO terms GO:0001664 - G protein-coupled receptor binding
GO:0002029 - desensitization of G protein-coupled receptor signaling pathway
GO:0004672 - protein kinase activity
GO:0004703 - G protein-coupled receptor kinase activity
GO:0005524 - ATP binding
and 7 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 689
Hs

1 688
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024