Protein: IDH3B
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Isocitric dehydrogenase subunit beta) (NAD(+)-specific ICDH subunit beta)

Gene: IDH3B
Organism: Homo sapiens
Interactions: 114
UniProt ID: O43837

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004449 - isocitrate dehydrogenase (NAD+) activity
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

229422

IDH3A
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

6

15

Small-scale

0.947

High

229425

IDH3G
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

3

15

High-throughput

0.861

High

229405

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

3

1

High-throughput

0.667

High

229390

MYC
Myc proto-oncogene protein

3

3

High-throughput

0.656

High

229411

GPDA
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

2

2

High-throughput

0.628

High

229380

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.584

High

229443

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

2

Small-scale

0.584

High

229407

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.536

High

229408

IRF2
Interferon regulatory factor 2

1

1

High-throughput

0.536

High

229453

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

229470

5NT3A
Cytosolic 5'-nucleotidase 3A

1

0

High-throughput

0.513

High

229441

MK06
Mitogen-activated protein kinase 6

1

6

High-throughput

0.508

High

229382

CISY
Citrate synthase, mitochondrial

1

4

High-throughput

0.479

High

229384

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

229386

BRD1
Bromodomain-containing protein 1

1

1

High-throughput

0.479

High

229388

LATS1
Serine/threonine-protein kinase LATS1

1

4

High-throughput

0.479

High

229389

EGFR
Epidermal growth factor receptor

1

4

High-throughput

0.479

High

229392

GCR
Glucocorticoid receptor

1

1

High-throughput

0.479

High

229393

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

229398

ADRB2
Beta-2 adrenergic receptor

1

3

High-throughput

0.479

High

229400

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

4

High-throughput

0.479

High

229403

CH60
60 kDa heat shock protein, mitochondrial

1

5

High-throughput

0.479

High

229409

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

229412

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

229413

STIP1
Stress-induced-phosphoprotein 1

1

3

High-throughput

0.479

High

229418

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

229419

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

229421

KC1A
Casein kinase I isoform alpha

1

1

High-throughput

0.479

High

229424

CDK9
Cyclin-dependent kinase 9

1

2

High-throughput

0.479

High

229429

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.479

High

229430

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

10

High-throughput

0.479

High

229431

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

1

High-throughput

0.479

High

229432

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

229433

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

3

High-throughput

0.479

High

229434

TRI14
Tripartite motif-containing protein 14

1

1

High-throughput

0.479

High

229436

PDK1
[Pyruvate dehydrogenase

1

2

High-throughput

0.479

High

229439

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.479

High

229444

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

229451

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

229457

KAT6A
Histone acetyltransferase KAT6A

1

1

High-throughput

0.479

High

229458

FBXW7
F-box/WD repeat-containing protein 7

1

3

High-throughput

0.479

High

229463

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

229464

EFGM
Elongation factor G, mitochondrial

1

1

High-throughput

0.479

High

229465

MMS19
MMS19 nucleotide excision repair protein homolog

1

2

High-throughput

0.479

High

229478

LATS2
Serine/threonine-protein kinase LATS2

1

3

High-throughput

0.479

High

229479

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

229481

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

229483

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

229485

PRP19
Pre-mRNA-processing factor 19

1

6

High-throughput

0.479

High

125093

LEG9
Galectin-9

1

0

High-throughput

0.458

High

229383

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

229394

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

229401

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

229414

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

229417

8ODP
Oxidized purine nucleoside triphosphate hydrolase

1

0

Small-scale

0.458

High

229426

ATX3
Ataxin-3

1

0

Small-scale

0.458

High

229427

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

229442

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

High-throughput

0.458

High

229446

TECT3
Tectonic-3

1

0

High-throughput

0.458

High

229459

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

229468

TR61B
tRNA

1

0

High-throughput

0.458

High

229474

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

229484

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.458

High

229467

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.457

High

229395

JUN
Transcription factor Jun

1

2

High-throughput

0.445

High

229397

TBB5
Tubulin beta chain

1

1

High-throughput

0.445

High

229402

TAU
Microtubule-associated protein tau

1

6

High-throughput

0.445

High

229406

PIM1
Serine/threonine-protein kinase pim-1

1

2

High-throughput

0.445

High

229423

ERF
ETS domain-containing transcription factor ERF

1

1

High-throughput

0.445

High

229462

AURKB
Aurora kinase B

1

3

High-throughput

0.445

High

229480

OCAD1
OCIA domain-containing protein 1

1

1

High-throughput

0.445

High

229391

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

229415

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

229428

RHOG
Rho-related GTP-binding protein RhoG

1

3

High-throughput

0.437

High

229435

CUL7
Cullin-7

1

1

High-throughput

0.437

High

229449

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

229472

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

229475

ANLN
Anillin

1

2

High-throughput

0.437

High

229482

PD1L1
Programmed cell death 1 ligand 1

1

1

High-throughput

0.437

High

229486

CE164
Centrosomal protein of 164 kDa

1

1

High-throughput

0.437

High

126922

APBB1
Amyloid beta precursor protein binding family B member 1

1

0

High-throughput

0.426

High

229477

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.426

High

229438

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.417

High

229385

VENTX
Homeobox protein VENTX

1

3

High-throughput

0.407

High

229396

HEPS
Serine protease hepsin

1

1

High-throughput

0.407

High

229399

ACM4
Muscarinic acetylcholine receptor M4

1

4

High-throughput

0.407

High

229404

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

5

High-throughput

0.407

High

229410

KLK2
Kallikrein-2

1

7

High-throughput

0.407

High

229420

EAA2
Excitatory amino acid transporter 2

1

2

High-throughput

0.407

High

229448

ZNT10
Calcium/manganese antiporter SLC30A10

1

1

High-throughput

0.407

High

229450

SV2B
Synaptic vesicle glycoprotein 2B

1

1

High-throughput

0.407

High

229454

FXL16
F-box/LRR-repeat protein 16

1

2

High-throughput

0.407

High

229456

LPAR1
Lysophosphatidic acid receptor 1

1

6

High-throughput

0.407

High

229460

EMID1
EMI domain-containing protein 1

1

2

High-throughput

0.407

High

229471

DJC25
DnaJ homolog subfamily C member 25

1

2

High-throughput

0.407

High

229473

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

1

High-throughput

0.407

High

229487

ITM2B
Integral membrane protein 2B

1

6

High-throughput

0.407

High

229476

GDF3
Growth/differentiation factor 3

3

0

High-throughput

0.347

High

229461

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.298

High

229466

ATX2
Ataxin-2

1

0

High-throughput

0.282

High

127616

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

0

High-throughput

0.279

Low

221222

DCX
Neuronal migration protein doublecortin

1

0

High-throughput

0.279

Low

229416

CH3L1
Chitinase-3-like protein 1

1

0

High-throughput

0.279

Low

229440

CART

1

0

High-throughput

0.279

Low

229469

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.279

Low

184252

NPHP1
Nephrocystin-1

1

0

High-throughput

0.249

Low

229437

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.249

Low

229445

FTM
Protein fantom

1

0

High-throughput

0.249

Low

229452

CNTRL
Centriolin

1

0

High-throughput

0.249

Low

229455

POC5
Centrosomal protein POC5

1

0

High-throughput

0.249

Low

229488

PHLA3
Pleckstrin homology-like domain family A member 3

1

0

High-throughput

0.249

Low

229381

GSDME
Gasdermin-E

1

0

High-throughput

0.232

Low

229387

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.232

Low

229447

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025