HitPredict

Interactor 1: NFYB (P25208)
Nuclear transcription factor Y subunit beta (CAAT box DNA-binding protein subunit B) (Nuclear transcription factor Y subunit B) (NF-YB)
Gene: NFYB

Interactor 2: NFYC (Q13952)
Nuclear transcription factor Y subunit gamma (CAAT box DNA-binding protein subunit C) (Nuclear transcription factor Y subunit C) (NF-YC) (Transactivator HSM-1/2)
Gene: NFYC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.977

The method score is based on:

Property Details
Experiments 28514442, 32296183, 33961781, 35140242, 20936779, 26496610, 21988832, 12401788, unassigned1304
Identification Methods affinity chromatography technology, two hybrid, proximity labelling technology, x-ray crystallography, anti tag coimmunoprecipitation, validated two hybrid, two hybrid prey pooling approach, two hybrid array, two hybrid pooling approach
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains CBFD_NFYB_HMF~Histone
Common GO terms GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 - DNA binding
and 10 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 207
Hs

1 458
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Last updated: 15 Jul 2024