HitPredict

Interactor 1: SIS1 (P25294)
Protein SIS1
Gene: SIS1

Interactor 2: KSP1 (P38691)
Serine/threonine-protein kinase KSP1 (EC 2.7.11.1)
Gene: KSP1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	16319894, 37845327
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	DnaJ~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 352 Sc			1 1029
+	Sc
		633196 MAS5_YEAST (1-352): 1.41e-111: 332: 28.13		KSP1_YEAST (1-1029): 0: 1009: 98.64
+	Rn
		871239 DNJA1_RAT (1-352): 1.72e-120: 355: 28.93		AAPK1_RAT (64-609): 1.12e-119: 380: 15.33
+	Hs
		682157 DJB13_HUMAN (6-352): 1.55e-109: 323: 27.97		AKT2_HUMAN (42-418): 1.2e-127: 398: 16.41
+	Hs
		636252 DNJB1_HUMAN (5-352): 5.62e-109: 323: 34.09		AKT1_HUMAN (44-411): 1.96e-126: 394: 16.75
+	Sc
		419811 MAS5_YEAST (1-352): 1.41e-111: 332: 28.13		SNF1_YEAST (66-518): 6.63e-101: 332: 16.09
+	Sc
		419806 SIS1_YEAST (1-352): 6.96e-105: 313: 100.00		SNF1_YEAST (66-518): 6.63e-101: 332: 16.09
+	At
		187511 DNAJ3_ARATH (4-352): 7.67e-107: 320: 29.55		CIPKB_ARATH (83-470): 1.62e-100: 324: 17.84
+	Hs
		871447 DNJA4_HUMAN (1-352): 3.62e-119: 351: 28.65		AAPK2_HUMAN (75-377): 8.35e-77: 264: 22.36
+	Hs
		636288 DNJB1_HUMAN (5-352): 5.62e-109: 323: 34.09		AAPK2_HUMAN (75-377): 8.35e-77: 264: 22.36
+	Sc
		633158 MAS5_YEAST (1-352): 1.41e-111: 332: 28.13		CHK1_YEAST (134-335): 1.66e-19: 95.5: 32.56
+	Sc
		628297 SIS1_YEAST (1-352): 6.96e-105: 313: 100.00		FMP48_YEAST (105-292): 3.22e-19: 92.8: 34.93
+	Sc
		628623 SIS1_YEAST (1-352): 6.96e-105: 313: 100.00		SKS1_YEAST (14-351): 6.41e-16: 84: 27.47