HitPredict

Interactor 1: NLE1 (P25382)
Ribosome assembly protein 4 (Notchless protein homolog 1) (Ribosome biogenesis factor RSA4)
Gene: RSA4

Interactor 2: SPB4 (P25808)
ATP-dependent rRNA helicase SPB4 (EC 3.6.4.13) (Suppressor of PAB1 protein 4)
Gene: SPB4

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	30568249, 37811893, 21825077
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000027 - ribosomal large subunit assembly GO:0005730 - nucleolus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 515 Sc			1 606
+	Sc
		630886 NLE1_YEAST (1-515): 8.15e-148: 435: 100.00		HAS1_YEAST (6-467): 1.01e-156: 460: 30.98
+	Hs
		1271615 FBXW7_HUMAN (7-382): 1.11e-74: 251: 21.74		DDX17_HUMAN (2-463): 7.88e-127: 391: 21.89
+	Hs
		1271679 NLE1_HUMAN (212-514): 8.87e-77: 251: 23.16		DDX17_HUMAN (2-463): 7.88e-127: 391: 21.89
+	Hs
		903549 WDR5_HUMAN (1-213): 3.62e-47: 168: 16.97		DDX18_HUMAN (6-467): 8.02e-159: 472: 29.61
+	Sc
		635633 PWP2_YEAST (4-274): 1.32e-41: 161: 12.54		HAS1_YEAST (6-467): 1.01e-156: 460: 30.98
+	Hs
		134154 FBXW7_HUMAN (7-382): 1.11e-74: 251: 21.74		DDX3X_HUMAN (4-406): 1.31e-116: 363: 24.40
+	Sc
		630853 NLE1_YEAST (1-515): 8.15e-148: 435: 100.00		DRS1_YEAST (21-392): 3.9e-47: 178: 31.75
+	Sc
		635549 PWP2_YEAST (4-274): 1.32e-41: 161: 12.54		SPB4_YEAST (1-606): 2.46e-149: 445: 100.00
+	Hs
		903327 WDR5_HUMAN (1-213): 3.62e-47: 168: 16.97		DDX46_HUMAN (2-597): 8.55e-134: 418: 21.15
+	Sc
		415901 PWP2_YEAST (4-274): 1.32e-41: 161: 12.54		DED1_YEAST (3-402): 8.68e-139: 418: 25.55
+	Hs
		903410 WDR5_HUMAN (1-213): 3.62e-47: 168: 16.97		DDX17_HUMAN (2-463): 7.88e-127: 391: 21.89
+	Hs
		571382 WDR5_HUMAN (1-213): 3.62e-47: 168: 16.97		DDX5_HUMAN (2-454): 2.38e-125: 384: 22.34
+	Hs
		133956 WDR5_HUMAN (1-213): 3.62e-47: 168: 16.97		DDX3X_HUMAN (4-406): 1.31e-116: 363: 24.40
+	Hs
		1271700 FBW1A_HUMAN (154-389): 7.89e-18: 88.6: 27.66		DDX17_HUMAN (2-463): 7.88e-127: 391: 21.89
+	Hs
		571638 FBW1A_HUMAN (154-389): 7.89e-18: 88.6: 27.66		DDX5_HUMAN (2-454): 2.38e-125: 384: 22.34
+	Hs
		134256 FBW1A_HUMAN (154-389): 7.89e-18: 88.6: 27.66		DDX3X_HUMAN (4-406): 1.31e-116: 363: 24.40
+	Hs
		1281463 FBXW7_HUMAN (7-382): 1.11e-74: 251: 21.74		DDX41_HUMAN (18-394): 1.19e-47: 178: 30.95
+	Hs
		903507 WDR5_HUMAN (1-213): 3.62e-47: 168: 16.97		DDX47_HUMAN (23-382): 7.93e-54: 191: 34.35
+	Sc
		593593 PWP2_YEAST (4-274): 1.32e-41: 161: 12.54		DBP4_YEAST (21-467): 7e-51: 189: 31.36
+	Hs
		921718 GBB2_HUMAN (293-514): 7.83e-35: 135: 20.61		DDX47_HUMAN (23-382): 7.93e-54: 191: 34.35