HitPredict

Interactor 1: PSA1 (P25786)
Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain)
Gene: PSMA1

Interactor 2: PSMD6 (Q15008)
26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit RPN7) (26S proteasome regulatory subunit S10) (Breast cancer-associated protein SGA-113M) (Phosphonoformate immuno-associated protein 4) (Proteasome regulatory particle subunit p44S10) (p42A)
Gene: PSMD6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	26186194, 35271311, 17353931
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 263 Hs			1 389
+	Hs
		156291 PSA7_HUMAN (6-234): 9.99e-96: 282: 33.19		PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00
+	Hs
		656232 PSA5_HUMAN (1-236): 5.66e-93: 275: 28.81		PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00
+	Hs
		893673 PSA6_HUMAN (1-240): 1.64e-92: 274: 25.00		PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00
+	Hs
		638133 PSA4_HUMAN (1-233): 4.82e-91: 271: 28.75		PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00
+	Dm
		522501 PSA1_DROME (1-260): 4.06e-99: 292: 52.42		PSMD6_DROME (1-389): 2.36e-125: 368: 70.18
+	Dm
		1278633 PSA5_DROME (1-237): 4.05e-92: 273: 28.86		PSMD6_DROME (1-389): 2.36e-125: 368: 70.18
+	Hs
		893660 PSA6_HUMAN (1-240): 1.64e-92: 274: 25.00		CSN1_HUMAN (12-389): 3.49e-93: 289: 20.25
+	Hs
		121683 PSA1_HUMAN (1-263): 3.26e-109: 317: 100.00		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	Hs
		893638 PSA6_HUMAN (1-240): 1.64e-92: 274: 25.00		CSN2_HUMAN (22-388): 5.37e-90: 280: 13.67
+	Dm
		522490 PSA1_DROME (1-260): 4.06e-99: 292: 52.42		PSD11_DROME (7-387): 4.3e-77: 246: 13.32
+	Hs
		121635 PSA7_HUMAN (6-234): 9.99e-96: 282: 33.19		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	Hs
		121689 PSA5_HUMAN (1-236): 5.66e-93: 275: 28.81		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	Dm
		1180708 PSA5_DROME (1-237): 4.05e-92: 273: 28.86		PSD11_DROME (7-387): 4.3e-77: 246: 13.32
+	Hs
		121719 PSA6_HUMAN (1-240): 1.64e-92: 274: 25.00		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	Sc
		771354 PSA6_YEAST (1-233): 3.26e-83: 250: 52.77		RPN7_YEAST (11-389): 3.41e-86: 269: 35.47
+	Hs
		121685 PSA4_HUMAN (1-233): 4.82e-91: 271: 28.75		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	Dm
		611649 PSA71_DROME (4-233): 2.4e-38: 136: 33.48		PSMD6_DROME (1-389): 2.36e-125: 368: 70.18
+	Sc
		771361 PSA6_YEAST (1-233): 3.26e-83: 250: 52.77		RPN6_YEAST (30-389): 1.53e-56: 192: 12.57
+	Sp
		293717 PSA2_SCHPO (4-215): 4.27e-36: 130: 36.28		RPN6_SCHPO (5-386): 3.53e-81: 256: 13.80
+	Dm
		611643 PSA71_DROME (4-233): 2.4e-38: 136: 33.48		PSD11_DROME (7-387): 4.3e-77: 246: 13.32