HitPredict

Interactor 1: PSA2 (P25787)
Proteasome subunit alpha type-2 (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) (Proteasome component C3)
Gene: PSMA2

Interactor 2: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	22645313, 29426014, 30257870
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 234 Hs			1 875
+	Hs
		656207 PSA5_HUMAN (1-233): 2.69e-97: 285: 30.96		UBE3A_HUMAN (1-875): 0: 1058: 100.00
+	Hs
		893654 PSA6_HUMAN (2-234): 2.68e-90: 267: 34.73		UBE3A_HUMAN (1-875): 0: 1058: 100.00
+	Hs
		156275 PSA7_HUMAN (6-231): 1.49e-89: 266: 36.52		UBE3A_HUMAN (1-875): 0: 1058: 100.00
+	Hs
		637394 PSA1_HUMAN (1-233): 1.31e-89: 266: 30.67		UBE3A_HUMAN (1-875): 0: 1058: 100.00
+	Hs
		638114 PSA4_HUMAN (4-211): 1.24e-42: 146: 38.68		UBE3A_HUMAN (1-875): 0: 1058: 100.00
+	Hs
		656320 PSA5_HUMAN (1-233): 2.69e-97: 285: 30.96		SMUF1_HUMAN (405-872): 1.32e-175: 528: 27.04
+	Hs
		638134 PSA4_HUMAN (4-211): 1.24e-42: 146: 38.68		HERC3_HUMAN (139-874): 0: 582: 26.85
+	Hs
		638201 PSA4_HUMAN (4-211): 1.24e-42: 146: 38.68		SMUF1_HUMAN (405-872): 1.32e-175: 528: 27.04
+	Hs
		637712 PSA2_HUMAN (1-234): 2.95e-97: 285: 100.00		HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97
+	Hs
		656264 PSA5_HUMAN (1-233): 2.69e-97: 285: 30.96		HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97
+	Hs
		637692 PSA2_HUMAN (1-234): 2.95e-97: 285: 100.00		UBE3C_HUMAN (453-872): 2.23e-52: 200: 32.27
+	Hs
		656235 PSA5_HUMAN (1-233): 2.69e-97: 285: 30.96		UBE3C_HUMAN (453-872): 2.23e-52: 200: 32.27
+	Hs
		893701 PSA6_HUMAN (2-234): 2.68e-90: 267: 34.73		HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97
+	Hs
		156320 PSA7_HUMAN (6-231): 1.49e-89: 266: 36.52		HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97
+	Hs
		637468 PSA1_HUMAN (1-233): 1.31e-89: 266: 30.67		HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97
+	Hs
		893675 PSA6_HUMAN (2-234): 2.68e-90: 267: 34.73		UBE3C_HUMAN (453-872): 2.23e-52: 200: 32.27
+	Hs
		637427 PSA1_HUMAN (1-233): 1.31e-89: 266: 30.67		UBE3C_HUMAN (453-872): 2.23e-52: 200: 32.27
+	Hs
		638160 PSA4_HUMAN (4-211): 1.24e-42: 146: 38.68		HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97