HitPredict

Interactor 1: PSA3 (P25788)
Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8)
Gene: PSMA3

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	21988832
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 605
+	Hs
		637971 PSA3_HUMAN (1-255): 5.2e-97: 285: 100.00		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		656287 PSA5_HUMAN (1-239): 4.52e-96: 283: 31.97		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		893722 PSA6_HUMAN (4-242): 1.96e-95: 281: 29.34		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		638172 PSA4_HUMAN (4-236): 5.31e-94: 278: 27.43		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		637833 PSA3_HUMAN (1-255): 5.2e-97: 285: 100.00		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Hs
		637999 PSA3_HUMAN (1-255): 5.2e-97: 285: 100.00		TBL1R_HUMAN (501-605): 3.85e-15: 80.4: 16.67