Protein: ISY1
Pre-mRNA-splicing factor ISY1 homolog

Gene: ISY1
Organism: Homo sapiens
Interactions: 144
UniProt ID: Q9ULR0

Gene Ontology (top 5):
GO:0000350 - generation of catalytic spliceosome for second transesterification step
GO:0000389 - mRNA 3'-splice site recognition
GO:0000398 - mRNA splicing, via spliceosome
GO:0000974 - Prp19 complex
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1461664

PPIE
Peptidyl-prolyl cis-trans isomerase E

5

0

High-throughput

0.880

High

1387637

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

3

2

High-throughput

0.861

High

1412048

WDR83
WD repeat domain-containing protein 83

3

5

High-throughput

0.861

High

1415999

YJU2
Splicing factor YJU2

3

3

High-throughput

0.861

High

222544

PLRG1
Pleiotropic regulator 1

2

2

High-throughput

0.811

High

1461003

FBW1B
F-box/WD repeat-containing protein 11

2

0

High-throughput

0.770

High

1439439

SYF1
Pre-mRNA-splicing factor SYF1

5

6

High-throughput

0.722

High

1128149

DHX8
ATP-dependent RNA helicase DHX8

4

5

High-throughput

0.705

High

1461663

PRP19
Pre-mRNA-processing factor 19

4

4

High-throughput

0.699

High

485758

RU2A
U2 small nuclear ribonucleoprotein A'

4

2

Small-scale

0.696

High

251045

PRP17
Pre-mRNA-processing factor 17

1

6

High-throughput

0.691

High

1461667

PPIL1
Peptidyl-prolyl cis-trans isomerase-like 1

1

1

High-throughput

0.691

High

1346980

SNIP1
Smad nuclear-interacting protein 1

4

0

High-throughput

0.664

High

1461669

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

4

0

High-throughput

0.664

High

1227696

A16L1
Autophagy-related protein 16-1

2

2

High-throughput

0.659

High

245168

AQR
RNA helicase aquarius

3

0

Small-scale

0.642

High

1410081

USB1
U6 snRNA phosphodiesterase 1

3

0

High-throughput

0.638

High

1324816

KDM8
Bifunctional peptidase and arginyl-hydroxylase JMJD5

3

0

High-throughput

0.636

High

351364

SYF2
Pre-mRNA-splicing factor SYF2

2

1

High-throughput

0.628

High

974079

RUXF
Small nuclear ribonucleoprotein F

2

3

High-throughput

0.628

High

1398938

ZN830
Zinc finger protein 830

3

0

Small-scale

0.628

High

1452786

WSB2
WD repeat and SOCS box-containing protein 2

1

2

High-throughput

0.618

High

1241844

PRP8
Pre-mRNA-processing-splicing factor 8

1

3

High-throughput

0.618

High

1111896

TRA2A
Transformer-2 protein homolog alpha

2

1

High-throughput

0.611

High

1127236

RBM39
RNA-binding protein 39

2

2

High-throughput

0.611

High

1286230

RALYL
RNA-binding Raly-like protein

2

4

High-throughput

0.611

High

1290809

ZCH18
Zinc finger CCCH domain-containing protein 18

2

1

High-throughput

0.611

High

1404499

CDC5L
Cell division cycle 5-like protein

2

2

High-throughput

0.611

High

681951

RBTN2
Rhombotin-2

2

2

High-throughput

0.606

High

682120

RBTN1
Rhombotin-1

2

2

High-throughput

0.606

High

943828

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

4

High-throughput

0.606

High

973847

RUXE
Small nuclear ribonucleoprotein E

2

0

High-throughput

0.602

High

1089600

ILF2
Interleukin enhancer-binding factor 2

2

0

High-throughput

0.602

High

1090319

ELAV2
ELAV-like protein 2

2

0

High-throughput

0.602

High

1450693

DJC17
DnaJ homolog subfamily C member 17

2

0

High-throughput

0.602

High

134907

SAP18
Histone deacetylase complex subunit SAP18

2

0

High-throughput

0.585

High

666932

CCNC
Cyclin-C

2

0

High-throughput

0.580

High

827520

MLH1
DNA mismatch repair protein Mlh1

2

0

High-throughput

0.580

High

1385276

LENG1
Leukocyte receptor cluster member 1

2

0

High-throughput

0.580

High

1402961

ZN587
Zinc finger protein 587

2

0

High-throughput

0.580

High

1454668

RCOR3
REST corepressor 3

2

0

High-throughput

0.580

High

1458766

NXF1
Nuclear RNA export factor 1

2

0

High-throughput

0.580

High

1458988

ZN629
Zinc finger protein 629

2

0

High-throughput

0.580

High

1461668

NDK7
Nucleoside diphosphate kinase homolog 7

2

0

High-throughput

0.580

High

74643

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

3

High-throughput

0.536

High

256702

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

3

High-throughput

0.536

High

298114

SPF27
Pre-mRNA-splicing factor SPF27

1

2

High-throughput

0.536

High

462707

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

4

High-throughput

0.536

High

478255

SNRPA
U1 small nuclear ribonucleoprotein A

1

3

High-throughput

0.536

High

574512

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

2

High-throughput

0.536

High

594864

GCFC2
Intron Large complex component GCFC2

1

1

High-throughput

0.536

High

974865

SMD3
Small nuclear ribonucleoprotein Sm D3

1

3

High-throughput

0.536

High

991269

RSMN
Small nuclear ribonucleoprotein-associated protein N

1

2

High-throughput

0.536

High

1111354

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

1138747

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.536

High

1149221

SF3A1
Splicing factor 3A subunit 1

1

1

High-throughput

0.536

High

1180518

C19L2
CWF19-like protein 2

1

1

High-throughput

0.536

High

1229514

C19L1
CWF19-like protein 1

1

1

High-throughput

0.536

High

1356580

CCD12
Coiled-coil domain-containing protein 12

1

1

High-throughput

0.536

High

1411671

GPTC1
G patch domain-containing protein 1

1

1

High-throughput

0.536

High

1419981

CRNL1
Crooked neck-like protein 1

1

6

High-throughput

0.536

High

1434793

DHX35
Probable ATP-dependent RNA helicase DHX35

1

6

High-throughput

0.536

High

1451083

RBM22
Pre-mRNA-splicing factor RBM22

1

2

High-throughput

0.536

High

1458243

TFP11
Tuftelin-interacting protein 11

1

3

High-throughput

0.536

High

286508

WBP4
WW domain-binding protein 4

1

0

Small-scale

0.518

High

192661

NUP42
Nucleoporin NUP42

1

0

High-throughput

0.513

High

273019

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

High-throughput

0.513

High

326166

REC8
Meiotic recombination protein REC8 homolog

1

0

High-throughput

0.513

High

480348

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

542278

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

634692

LMNB1
Lamin-B1

1

0

High-throughput

0.513

High

993809

UBC9
SUMO-conjugating enzyme UBC9

1

0

High-throughput

0.513

High

1065487

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.513

High

1099599

SRSF6
Serine/arginine-rich splicing factor 6

1

0

High-throughput

0.513

High

1109236

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

0

High-throughput

0.513

High

1152295

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

1160340

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.513

High

1168923

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

0

High-throughput

0.513

High

1204403

SGO1
Shugoshin 1

1

0

High-throughput

0.513

High

1252546

LN28B
Protein lin-28 homolog B

1

0

High-throughput

0.513

High

1257841

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.513

High

1361542

CTBL1
Beta-catenin-like protein 1

1

0

High-throughput

0.513

High

1387422

ESS2
Splicing factor ESS-2 homolog

1

0

High-throughput

0.513

High

1387911

PABP5
Polyadenylate-binding protein 5

1

0

High-throughput

0.513

High

1432383

PININ
Pinin

1

0

High-throughput

0.513

High

1453663

CWC15
Spliceosome-associated protein CWC15 homolog

1

0

High-throughput

0.513

High

1461666

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.513

High

1461662

ISY1
Pre-mRNA-splicing factor ISY1 homolog

1

1

High-throughput

0.508

High

1148083

SF3B3
Splicing factor 3B subunit 3

1

1

Small-scale

0.501

High

698068

CALR
Calreticulin

1

0

High-throughput

0.493

High

788261

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.493

High

1351895

NEK7
Serine/threonine-protein kinase Nek7

1

0

High-throughput

0.493

High

1460995

PTBP2
Polypyrimidine tract-binding protein 2

1

1

High-throughput

0.481

High

260604

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

473173

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.479

High

879608

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

974219

RUXG
Small nuclear ribonucleoprotein G

1

6

High-throughput

0.479

High

1141358

BRD3
Bromodomain-containing protein 3

1

1

High-throughput

0.479

High

1459286

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1460289

XPO7
Exportin-7

1

1

High-throughput

0.479

High

129545

MEN1
Menin

1

0

High-throughput

0.458

High

316149

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

335934

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

0

High-throughput

0.458

High

346488

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

607216

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

775734

DEK
Protein DEK

1

0

High-throughput

0.458

High

881627

CDK8
Cyclin-dependent kinase 8

1

0

High-throughput

0.458

High

905284

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

920356

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.458

High

971277

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

980530

H4
Histone H4

1

0

High-throughput

0.458

High

1133044

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

High-throughput

0.458

High

1137582

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

1201293

EAPP
E2F-associated phosphoprotein

1

0

High-throughput

0.458

High

1313523

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1314728

SRRM1
Serine/arginine repetitive matrix protein 1

1

0

High-throughput

0.458

High

1352828

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1415908

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1447426

ANLN
Anillin

1

0

High-throughput

0.458

High

71626

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

6

High-throughput

0.445

High

942954

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.437

High

1460689

DDX41
Probable ATP-dependent RNA helicase DDX41

1

0

High-throughput

0.426

High

1256760

NKAP1
Uncharacterized protein NKAPD1

2

0

High-throughput

0.328

High

1371475

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

0

High-throughput

0.328

High

1383611

K1143
Uncharacterized protein KIAA1143

2

0

High-throughput

0.328

High

220317

FRS3
Fibroblast growth factor receptor substrate 3

2

0

High-throughput

0.316

High

334478

SYFM
Phenylalanine--tRNA ligase, mitochondrial

2

0

High-throughput

0.316

High

1214470

TSTD2
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2

2

0

High-throughput

0.316

High

1295128

F90A1
Protein FAM90A1

2

0

High-throughput

0.316

High

1315150

EXOC8
Exocyst complex component 8

2

0

High-throughput

0.316

High

1330181

CC185
Coiled-coil domain-containing protein 185

2

0

High-throughput

0.316

High

1398657

F161B
Protein FAM161B

2

0

High-throughput

0.316

High

1433879

FBX44
F-box only protein 44

2

0

High-throughput

0.316

High

64916

RCCD1
RCC1 domain-containing protein 1

1

0

High-throughput

0.279

Low

591393

CD44
CD44 antigen

1

0

High-throughput

0.279

Low

1348991

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

1461665

ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

1

0

High-throughput

0.279

Low

789038

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.268

Low

1322750

PORIM
Porimin

1

0

High-throughput

0.268

Low

995503

TPM4
Tropomyosin alpha-4 chain

1

0

High-throughput

0.249

Low

995891

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.249

Low

1256068

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1434214

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025