HitPredict

Interactor 1: RBTN2 (P25791)
Rhombotin-2 (Cysteine-rich protein TTG-2) (LIM domain only protein 2) (LMO-2) (T-cell translocation protein 2)
Gene: LMO2

Interactor 2: LMO4 (P61968)
LIM domain transcription factor LMO4 (Breast tumor autoantigen) (LIM domain only protein 4) (LMO-4)
Gene: LMO4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	LIM~LIM
Common GO terms	GO:0005667 - transcription regulator complex GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046872 - metal ion binding GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 158 Hs			1 165
+	Hs
		903736 LHX8_HUMAN (24-148): 1.1e-47: 159: 33.60		LMO4_HUMAN (1-165): 1.95e-43: 143: 100.00
+	Ce
		104771 LIM7_CAEEL (14-147): 4.14e-45: 155: 33.82		LIN11_CAEEL (7-156): 1.29e-39: 139: 29.14
+	Ce
		104772 LIM7_CAEEL (14-147): 4.14e-45: 155: 33.82		HM14_CAEEL (1-157): 1.01e-39: 138: 28.30
+	Hs
		903764 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		LMO4_HUMAN (1-165): 1.95e-43: 143: 100.00
+	Hs
		899930 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		ISL1_HUMAN (22-162): 3.73e-39: 137: 36.55
+	Hs
		1251421 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		LMO3_HUMAN (13-152): 4.29e-41: 136: 47.86
+	Hs
		638556 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		RBTN1_HUMAN (1-143): 1.92e-36: 125: 48.25
+	Hs
		638365 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		RBTN2_HUMAN (23-140): 7.68e-36: 123: 46.61
+	Dm
		114396 M9PCA3_DROME (9-154): 8.59e-41: 145: 32.65		M9PCA3_DROME (19-140): 2.65e-23: 97.1: 44.36
+	Dm
		1368258 Q9VJ37_DROME (24-153): 1.03e-45: 158: 34.09		Q9VJ00_DROME (12-79): 1.65e-10: 60: 18.84
+	Dm
		114751 P92031_DROME (24-153): 1.22e-45: 157: 34.09		M9PD53_DROME (12-79): 1.17e-10: 60.8: 18.84
+	Dm
		112552 Q9VJ37_DROME (24-153): 1.03e-45: 158: 34.09		M9NCY1_DROME (12-79): 3.82e-10: 59.3: 18.84
+	Hs
		1148497 LHX8_HUMAN (24-148): 1.1e-47: 159: 33.60		LHX6_HUMAN (82-165): 9.62e-10: 57.7: 18.75
+	Hs
		1148484 LHX8_HUMAN (24-148): 1.1e-47: 159: 33.60		ISL2_HUMAN (76-152): 4.78e-09: 55.8: 16.88
+	Hs
		1281161 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		LHX4_HUMAN (82-165): 1.58e-12: 65.8: 18.75
+	Hs
		238115 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		LMX1B_HUMAN (12-80): 8.72e-11: 60.8: 30.00
+	Hs
		1283500 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		LHX3_HUMAN (15-78): 1.96e-10: 60.1: 23.08
+	Hs
		822660 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		LHX1_HUMAN (12-77): 4.61e-10: 58.9: 23.88
+	Hs
		839800 ISL2_HUMAN (12-148): 1.24e-41: 143: 32.61		LHX2_HUMAN (15-85): 1.62e-09: 57.4: 25.00