Protein: S1PR4
Sphingosine 1-phosphate receptor 4 (S1P receptor 4) (S1P4) (Endothelial differentiation G-protein coupled receptor 6) (Sphingosine 1-phosphate receptor Edg-6) (S1P receptor Edg-6)

Gene: S1PR4
Organism: Homo sapiens
Interactions: 147
UniProt ID: O95977

Gene Ontology (top 5):
GO:0004930 - G protein-coupled receptor activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005886 - plasma membrane
GO:0007186 - G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

351891

GNA12
Guanine nucleotide-binding protein subunit alpha-12

1

20

Small-scale

0.647

High

351986

TBC24
TBC1 domain family member 24

2

5

High-throughput

0.628

High

351969

SEC12
Guanine nucleotide-exchange factor SEC12

1

4

High-throughput

0.618

High

351886

GEMI4
Gem-associated protein 4

2

1

High-throughput

0.606

High

351880

PSN1
Presenilin-1

2

2

High-throughput

0.601

High

351868

PPAL
Lysosomal acid phosphatase

2

6

High-throughput

0.549

High

351920

NOP9
Nucleolar protein 9

2

4

High-throughput

0.549

High

351974

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

2

4

High-throughput

0.549

High

351990

MAN1
Inner nuclear membrane protein Man1

2

3

High-throughput

0.549

High

178131

NPC1
NPC intracellular cholesterol transporter 1

1

10

High-throughput

0.536

High

190582

MRP4
ATP-binding cassette sub-family C member 4

1

7

High-throughput

0.536

High

215474

EMC8
ER membrane protein complex subunit 8

1

1

High-throughput

0.536

High

220838

XPOT
Exportin-T

1

17

High-throughput

0.536

High

297126

PRAF3
PRA1 family protein 3

1

6

High-throughput

0.536

High

349350

TSN15
Tetraspanin-15

1

20

High-throughput

0.536

High

351866

B3A2
Anion exchange protein 2

1

7

High-throughput

0.536

High

351869

CY24A
Cytochrome b-245 light chain

1

2

High-throughput

0.536

High

351870

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

20

High-throughput

0.536

High

351872

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

20

High-throughput

0.536

High

351873

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

20

High-throughput

0.536

High

351875

AOFB
Amine oxidase [flavin-containing] B

1

2

High-throughput

0.536

High

351878

EAA3
Excitatory amino acid transporter 3

1

4

High-throughput

0.536

High

351879

AGRE5
Adhesion G protein-coupled receptor E5

1

14

High-throughput

0.536

High

351881

RAB13
Ras-related protein Rab-13

1

4

High-throughput

0.536

High

351882

CAV2
Caveolin-2

1

4

High-throughput

0.536

High

351884

AT12A
Potassium-transporting ATPase alpha chain 2

1

20

High-throughput

0.536

High

351885

SYJ2B
Synaptojanin-2-binding protein

1

20

High-throughput

0.536

High

351888

AT2C1
Calcium-transporting ATPase type 2C member 1

1

20

High-throughput

0.536

High

351889

PIPNA
Phosphatidylinositol transfer protein alpha isoform

1

1

High-throughput

0.536

High

351890

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

20

High-throughput

0.536

High

351892

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

4

High-throughput

0.536

High

351893

S39A6
Zinc transporter ZIP6

1

20

High-throughput

0.536

High

351894

TMED1
Transmembrane emp24 domain-containing protein 1

1

5

High-throughput

0.536

High

351896

EMC2
ER membrane protein complex subunit 2

1

4

High-throughput

0.536

High

351897

MSMO1
Methylsterol monooxygenase 1

1

7

High-throughput

0.536

High

351898

MICA
MHC class I polypeptide-related sequence A

1

3

High-throughput

0.536

High

351900

ANO6
Anoctamin-6

1

4

High-throughput

0.536

High

351905

GP107
Protein GPR107

1

6

High-throughput

0.536

High

351907

INT3
Integrator complex subunit 3

1

1

High-throughput

0.536

High

351909

IPIL1
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1

1

4

High-throughput

0.536

High

351912

CNNM4
Metal transporter CNNM4

1

8

High-throughput

0.536

High

351913

S39A4
Zinc transporter ZIP4

1

20

High-throughput

0.536

High

351921

GP180
Integral membrane protein GPR180

1

6

High-throughput

0.536

High

351925

TM87A
Transmembrane protein 87A

1

6

High-throughput

0.536

High

351926

DGLB
Diacylglycerol lipase-beta

1

5

High-throughput

0.536

High

351927

ZNT7
Zinc transporter 7

1

15

High-throughput

0.536

High

351929

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

15

High-throughput

0.536

High

351931

TBC15
TBC1 domain family member 15

1

9

High-throughput

0.536

High

351934

LMBR1
Limb region 1 protein homolog

1

2

High-throughput

0.536

High

351937

MRP2
ATP-binding cassette sub-family C member 2

1

7

High-throughput

0.536

High

351940

GCP3
Gamma-tubulin complex component 3

1

7

High-throughput

0.536

High

351947

IPO9
Importin-9

1

14

High-throughput

0.536

High

351948

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

9

High-throughput

0.536

High

351949

MMS19
MMS19 nucleotide excision repair protein homolog

1

1

High-throughput

0.536

High

351951

TM9S2
Transmembrane 9 superfamily member 2

1

13

High-throughput

0.536

High

351952

S29A1
Equilibrative nucleoside transporter 1

1

3

High-throughput

0.536

High

351953

TS101
Tumor susceptibility gene 101 protein

1

2

High-throughput

0.536

High

351954

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

5

High-throughput

0.536

High

351956

SGPP1
Sphingosine-1-phosphate phosphatase 1

1

1

High-throughput

0.536

High

351960

TTYH3
Protein tweety homolog 3

1

11

High-throughput

0.536

High

351961

YIPF3
Protein YIPF3

1

6

High-throughput

0.536

High

351963

INT2
Integrator complex subunit 2

1

2

High-throughput

0.536

High

351964

METL9
Protein-L-histidine N-pros-methyltransferase

1

1

High-throughput

0.536

High

351965

GHITM
Growth hormone-inducible transmembrane protein

1

5

High-throughput

0.536

High

351968

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

1

4

High-throughput

0.536

High

351970

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

1

3

High-throughput

0.536

High

351972

PLCC
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

1

8

High-throughput

0.536

High

351975

RMND1
Required for meiotic nuclear division protein 1 homolog

1

3

High-throughput

0.536

High

351977

TM160
Transmembrane protein 160

1

3

High-throughput

0.536

High

351979

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

1

6

High-throughput

0.536

High

351980

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

1

1

High-throughput

0.536

High

351981

ATX10
Ataxin-10

1

1

High-throughput

0.536

High

351984

LCAP
Leucyl-cystinyl aminopeptidase

1

4

High-throughput

0.536

High

351985

S39AA
Zinc transporter ZIP10

1

20

High-throughput

0.536

High

351987

TMCO1
Calcium load-activated calcium channel

1

3

High-throughput

0.536

High

351992

CIA30
Complex I intermediate-associated protein 30, mitochondrial

1

5

High-throughput

0.536

High

351994

SAM50
Sorting and assembly machinery component 50 homolog

1

1

High-throughput

0.536

High

351995

TNPO3
Transportin-3

1

20

High-throughput

0.536

High

351996

FLVC1
Choline/ethanolamine transporter FLVCR1

1

2

High-throughput

0.536

High

351867

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

6

High-throughput

0.514

High

351895

LBR
Delta(14)-sterol reductase LBR

1

0

High-throughput

0.513

High

351973

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.513

High

186396

TM9S1
Transmembrane 9 superfamily member 1

1

13

High-throughput

0.489

High

189084

IPO8
Importin-8

1

14

High-throughput

0.489

High

211709

ZW10
Centromere/kinetochore protein zw10 homolog

1

2

High-throughput

0.489

High

225351

ERD23
ER lumen protein-retaining receptor 3

1

7

High-throughput

0.489

High

276935

MPU1
Mannose-P-dolichol utilization defect 1 protein

1

1

High-throughput

0.489

High

316472

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

4

High-throughput

0.489

High

341384

CDS2
Phosphatidate cytidylyltransferase 2

1

2

High-throughput

0.489

High

351874

ERD21
ER lumen protein-retaining receptor 1

1

7

High-throughput

0.489

High

351887

CNTP1
Contactin-associated protein 1

1

10

High-throughput

0.489

High

351902

MBRL
Membralin

1

5

High-throughput

0.489

High

351903

YIF1B
Protein YIF1B

1

3

High-throughput

0.489

High

351904

NOM1
Nucleolar MIF4G domain-containing protein 1

1

1

High-throughput

0.489

High

351906

TBC9B
TBC1 domain family member 9B

1

3

High-throughput

0.489

High

351910

RINT1
RAD50-interacting protein 1

1

4

High-throughput

0.489

High

351911

TTC27
Tetratricopeptide repeat protein 27

1

3

High-throughput

0.489

High

351914

THADA
tRNA

1

7

High-throughput

0.489

High

351915

CERS6
Ceramide synthase 6

1

15

High-throughput

0.489

High

351916

ERMP1
Endoplasmic reticulum metallopeptidase 1

1

5

High-throughput

0.489

High

351917

MON2
Protein MON2 homolog

1

6

High-throughput

0.489

High

351918

FRMD5
FERM domain-containing protein 5

1

6

High-throughput

0.489

High

351922

ZDH13
Palmitoyltransferase ZDHHC13

1

7

High-throughput

0.489

High

351923

K2013
Uncharacterized protein KIAA2013

1

6

High-throughput

0.489

High

351930

GOGA5
Golgin subfamily A member 5

1

4

High-throughput

0.489

High

351933

THEM6
Protein THEM6

1

3

High-throughput

0.489

High

351935

TM9S4
Transmembrane 9 superfamily member 4

1

13

High-throughput

0.489

High

351938

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

20

High-throughput

0.489

High

351939

YIPF5
Protein YIPF5

1

6

High-throughput

0.489

High

351941

F241B
Protein FAM241B

1

6

High-throughput

0.489

High

351942

SAAL1
Protein SAAL1

1

3

High-throughput

0.489

High

351943

CERS2
Ceramide synthase 2

1

15

High-throughput

0.489

High

351944

RN185
E3 ubiquitin-protein ligase RNF185

1

7

High-throughput

0.489

High

351946

MBOA7
Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7

1

9

High-throughput

0.489

High

351950

SGMR1
Sigma non-opioid intracellular receptor 1

1

6

High-throughput

0.489

High

351955

PTSS2
Phosphatidylserine synthase 2

1

7

High-throughput

0.489

High

351957

FACD2
Fanconi anemia group D2 protein

1

5

High-throughput

0.489

High

351958

FUT8
Alpha-(1,6)-fucosyltransferase

1

3

High-throughput

0.489

High

351962

DERL2
Derlin-2

1

4

High-throughput

0.489

High

351967

AT133
Polyamine-transporting ATPase 13A3

1

20

High-throughput

0.489

High

351971

TM9S3
Transmembrane 9 superfamily member 3

1

13

High-throughput

0.489

High

351978

T161A
Transmembrane protein 161A

1

5

High-throughput

0.489

High

351982

CS025
UPF0449 protein C19orf25

1

1

High-throughput

0.489

High

351983

IPO11
Importin-11

1

15

High-throughput

0.489

High

351988

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

2

High-throughput

0.489

High

351989

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

9

High-throughput

0.489

High

351993

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

2

High-throughput

0.489

High

351997

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

6

High-throughput

0.489

High

186234

SIVA
Apoptosis regulatory protein Siva

1

1

Small-scale

0.479

High

351063

ECD
Protein ecdysoneless homolog

1

2

High-throughput

0.445

High

351871

FABP4
Fatty acid-binding protein, adipocyte

1

1

High-throughput

0.445

High

351876

SDC4
Syndecan-4

1

2

High-throughput

0.445

High

351877

PI4KA
Phosphatidylinositol 4-kinase alpha

1

11

High-throughput

0.445

High

351883

CLCN3
H(+)/Cl(-) exchange transporter 3

1

1

High-throughput

0.445

High

351919

DSG4
Desmoglein-4

1

5

High-throughput

0.445

High

351924

ARL10
ADP-ribosylation factor-like protein 10

1

16

High-throughput

0.445

High

351928

RAI3
Retinoic acid-induced protein 3

1

18

High-throughput

0.445

High

351932

LRC15
Leucine-rich repeat-containing protein 15

1

4

High-throughput

0.445

High

351966

GOLP3
Golgi phosphoprotein 3

1

6

High-throughput

0.445

High

351901

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

10

High-throughput

0.437

High

351945

SREC2
Scavenger receptor class F member 2

1

1

High-throughput

0.407

High

351899

GNPTA
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta

1

0

High-throughput

0.279

Low

351936

NU205
Nuclear pore complex protein Nup205

1

0

High-throughput

0.279

Low

351959

OSBL8
Oxysterol-binding protein-related protein 8

1

0

High-throughput

0.279

Low

351976

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

High-throughput

0.279

Low

351991

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.279

Low

351908

DMKN
Dermokine

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025