HitPredict

Interactor 1: NFKB1 (P25799)
Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (NF-kappa-B1 p84/NF-kappa-B1 p98) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
Gene: NFKB1

Interactor 2: TF65 (Q04207)
Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
Gene: Rela

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.987

The method score is based on:

Property Details
Experiments 23538752, 19887633, 9450761, 20740013, 21220295, 10356322, 15657065, 9405619, 16260626, 19531803, 19592489, 19652026, 18586011, 10906187, 9556555, 20211142, 11970949, 17254973, 21056038
Identification Methods pull down, surface plasmon resonance, x-ray crystallography, molecular sieving, anti bait coimmunoprecipitation, electrophoretic mobility supershift assay, anti tag coimmunoprecipitation, two hybrid, two hybrid array, tandem affinity purification
Interaction Type direct interaction, physical association, other modification, association

The annotation score is based on:

Property Details
Interacting Pfam domains Ank~RHD_dimer, Ank_2~RHD_dimer, RHD_dimer~RHD_dimer, RHD_DNA_bind~RHD_dimer, RHD_DNA_bind~RHD_DNA_bind
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
and 29 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 971
Mm

1 549
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Last updated: 15 Jul 2024