HitPredict

Interactor 1: IKBA (P25963)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
Gene: NFKBIA

Interactor 2: TERA (P55072)
Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP)
Gene: VCP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.959

Property	Details
Experiments	26463447, 9452483, 23383273, 24248593, 10930447, 23393163, 14743216
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	AAA_lid_3~Ank_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 317 Hs			1 806
+	Hs
		121577 IKBE_HUMAN (3-315): 1.28e-74: 239: 32.10		TERA_HUMAN (1-806): 0: 749: 100.00
+	Hs
		874830 NFKB2_HUMAN (68-294): 6.66e-64: 218: 34.32		TERA_HUMAN (1-806): 0: 749: 100.00
+	Hs
		874739 RIPK4_HUMAN (136-316): 6.43e-34: 133: 24.31		TERA_HUMAN (1-806): 0: 749: 100.00
+	Hs
		875317 Q9H4D1_HUMAN (136-316): 1.24e-33: 132: 24.31		TERA_HUMAN (1-806): 0: 749: 100.00
+	Hs
		587482 NFKB1_HUMAN (31-196): 3.47e-20: 93.1: 23.35		TERA_HUMAN (1-806): 0: 749: 100.00
+	Hs
		875096 ANKH1_HUMAN (4-107): 2.55e-18: 87.9: 6.73		TERA_HUMAN (1-806): 0: 749: 100.00
+	Hs
		874969 IKBB_HUMAN (68-169): 5.17e-13: 70.8: 28.16		TERA_HUMAN (1-806): 0: 749: 100.00
+	Hs
		883564 RIPK4_HUMAN (136-316): 6.43e-34: 133: 24.31		AFG2A_HUMAN (85-429): 1.24e-69: 248: 33.14
+	Hs
		1239604 Q9H4D1_HUMAN (136-316): 1.24e-33: 132: 24.31		AFG2A_HUMAN (85-429): 1.24e-69: 248: 33.14
+	Hs
		883634 RIPK4_HUMAN (136-316): 6.43e-34: 133: 24.31		AFG2B_HUMAN (457-801): 2.18e-65: 234: 30.75
+	Hs
		1314130 Q9H4D1_HUMAN (136-316): 1.24e-33: 132: 24.31		AFG2B_HUMAN (457-801): 2.18e-65: 234: 30.75
+	Hs
		1302640 Q96T11_HUMAN (136-316): 4.96e-33: 130: 23.76		AFG2B_HUMAN (457-801): 2.18e-65: 234: 30.75