HitPredict

Interactor 1: SPDE4 (A6NLX3)
Speedy protein E4
Gene: SPDYE4

Interactor 2: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.51	0.80	0.640

Property	Details
Experiments	35016035
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~Spy1
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 237 Hs			1 298
+	Hs
		64006 SPDE4_HUMAN (1-237): 3e-122: 348: 100.00		CDK3_HUMAN (1-294): 1.8e-154: 435: 76.87
+	Hs
		625476 SPDE7_HUMAN (55-237): 2.76e-104: 302: 66.35		CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00
+	Hs
		63987 SPDE4_HUMAN (1-237): 3e-122: 348: 100.00		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Hs
		64007 SPDE4_HUMAN (1-237): 3e-122: 348: 100.00		CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39
+	Hs
		414944 SPDE7_HUMAN (55-237): 2.76e-104: 302: 66.35		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Hs
		625485 SPDYA_HUMAN (67-235): 5.06e-70: 218: 35.84		CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00
+	Hs
		625484 SPDYC_HUMAN (104-233): 3.82e-65: 204: 45.80		CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00
+	Hs
		64008 SPDE4_HUMAN (1-237): 3e-122: 348: 100.00		CDK16_HUMAN (1-286): 4.1e-107: 322: 55.40
+	Xl
		724514 SPD1A_XENLA (70-235): 7.02e-75: 230: 41.32		CDK1A_XENLA (1-291): 1.26e-143: 407: 67.12
+	Xl
		621606 SPD1A_XENLA (70-235): 7.02e-75: 230: 41.32		CDK1B_XENLA (1-291): 1.1e-142: 405: 66.78
+	Hs
		414952 SPDYA_HUMAN (67-235): 5.06e-70: 218: 35.84		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Hs
		414951 SPDYC_HUMAN (104-233): 3.82e-65: 204: 45.80		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Hs
		960292 SPDYA_HUMAN (67-235): 5.06e-70: 218: 35.84		CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39
+	Hs
		625518 SPDE1_HUMAN (36-113): 2.35e-17: 81.3: 62.82		CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00
+	Hs
		960374 SPDYA_HUMAN (67-235): 5.06e-70: 218: 35.84		CDK16_HUMAN (1-286): 4.1e-107: 322: 55.40
+	Hs
		414999 SPDE1_HUMAN (36-113): 2.35e-17: 81.3: 62.82		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Hs
		960311 SPDE1_HUMAN (36-113): 2.35e-17: 81.3: 62.82		CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39