Protein: UBC4
Ubiquitin-conjugating enzyme E2 4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 4) (Ubiquitin carrier protein 4) (Ubiquitin-protein ligase 4)

Gene: UBC4
Organism: Saccharomyces cerevisiae S288C
Interactions: 85
UniProt ID: P15731

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

585741

APC11
Anaphase-promoting complex subunit 11

22

20

Small-scale

0.989

High

585709

RSP5
E3 ubiquitin-protein ligase RSP5

16

20

Small-scale

0.985

High

585697

NOT4
General negative regulator of transcription subunit 4

8

11

Small-scale

0.967

High

585695

UFD4
Ubiquitin fusion degradation protein 4

5

20

Small-scale

0.924

High

585681

UBA1
Ubiquitin-activating enzyme E1 1

4

20

Small-scale

0.888

High

585701

TUL1
Transmembrane E3 ubiquitin-protein ligase 1

3

2

Small-scale

0.868

High

585711

SLX8
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8

3

1

Small-scale

0.845

High

585675

UBC4
Ubiquitin-conjugating enzyme E2 4

3

16

Small-scale

0.840

High

585728

PEX10
Peroxisome biogenesis factor 10

2

20

Small-scale

0.778

High

585731

PIB1
E3 ubiquitin-protein ligase PIB1

2

3

Small-scale

0.778

High

585735

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

2

20

Small-scale

0.778

High

585737

RBX1
RING-box protein HRT1

2

20

Small-scale

0.778

High

585676

UBC5
Ubiquitin-conjugating enzyme E2-16 kDa

2

17

Small-scale

0.776

High

585702

HEL1
E3 ubiquitin-protein ligase HEL1

1

20

Small-scale

0.724

High

585729

HEL2
E3 ubiquitin-protein ligase HEL2

5

3

Small-scale

0.718

High

585693

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

4

1

Small-scale

0.686

High

585719

CDH1
APC/C activator protein CDH1

3

12

Small-scale

0.655

High

509374

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

20

Small-scale

0.647

High

585721

UFD2
E4 ubiquitin-protein ligase UFD2

1

20

Small-scale

0.647

High

585730

MAG2
E3 ubiquitin-protein ligase MAG2

1

20

Small-scale

0.647

High

578769

HSC82
ATP-dependent molecular chaperone HSC82

3

3

High-throughput

0.640

High

585684

RS5
Small ribosomal subunit protein uS7

3

0

Small-scale

0.627

High

585692

PEX2
Peroxisomal biogenesis factor 2

3

0

Small-scale

0.623

High

585717

HUL5
E3 ubiquitin-protein ligase HUL5

1

20

Small-scale

0.618

High

585722

H3
Histone H3

1

3

Small-scale

0.618

High

585705

DMA1
E3 ubiquitin-protein ligase DMA1

2

2

Small-scale

0.602

High

585679

PSB4
Proteasome subunit beta type-4

2

5

Small-scale

0.571

High

556586

PEP5
E3 ubiquitin-protein ligase PEP5

1

1

Small-scale

0.561

High

585718

SNT2
E3 ubiquitin-protein ligase SNT2

1

1

Small-scale

0.561

High

585704

RPN1
26S proteasome regulatory subunit RPN1

1

0

Small-scale

0.527

High

585706

NACA
Nascent polypeptide-associated complex subunit alpha

1

1

Small-scale

0.508

High

585724

NACB1
Nascent polypeptide-associated complex subunit beta-1

1

2

Small-scale

0.508

High

585689

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

1

3

Small-scale

0.501

High

585707

RPN10
26S proteasome regulatory subunit RPN10

1

1

Small-scale

0.501

High

585720

DMA2
E3 ubiquitin-protein ligase DMA2

1

2

Small-scale

0.501

High

585723

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

7

Small-scale

0.501

High

585726

PEX12
Peroxisome assembly protein 12

1

1

Small-scale

0.501

High

585699

MPE1
Protein MPE1

1

0

Small-scale

0.480

High

585708

POP2
Poly(A) ribonuclease POP2

1

0

Small-scale

0.480

High

408282

GAL1
Galactokinase

1

0

High-throughput

0.479

High

585736

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

0

High-throughput

0.479

High

392159

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.479

High

518187

IF4A
ATP-dependent RNA helicase eIF4A

1

1

High-throughput

0.479

High

548663

RNA1
Ran GTPase-activating protein 1

1

2

High-throughput

0.479

High

585680

RAD53
Serine/threonine-protein kinase RAD53

1

2

Small-scale

0.479

High

585698

PEX5
Peroxisomal targeting signal receptor

1

1

Small-scale

0.479

High

585713

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

4

High-throughput

0.479

High

585714

CUL8
Cullin-8

1

17

Small-scale

0.479

High

585733

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.479

High

585734

SUB2
ATP-dependent RNA helicase SUB2

1

2

High-throughput

0.479

High

585738

ULS1
ATP-dependent helicase ULS1

1

12

Small-scale

0.479

High

585691

KAR9
Karyogamy protein KAR9

1

0

Small-scale

0.460

High

585710

SPC25
Kinetochore protein SPC25

1

0

High-throughput

0.460

High

434786

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

514426

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

585677

CCA1
CCA tRNA nucleotidyltransferase, mitochondrial

1

0

High-throughput

0.458

High

585682

KCC2
Calcium/calmodulin-dependent protein kinase II

1

0

High-throughput

0.458

High

585683

NOT1
General negative regulator of transcription subunit 1

1

0

High-throughput

0.458

High

585686

URA7
CTP synthase 1

1

0

High-throughput

0.458

High

585687

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

585690

HS104
Heat shock protein 104

1

0

High-throughput

0.458

High

585703

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

585715

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.458

High

585716

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

585742

AHA1
Hsp90 co-chaperone AHA1

1

0

High-throughput

0.458

High

525830

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

585688

PSB5
Proteasome subunit beta type-5

1

4

Small-scale

0.445

High

585712

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.445

High

383490

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

502818

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

585685

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.437

High

585700

YKT6
Synaptobrevin homolog YKT6

1

1

High-throughput

0.437

High

585739

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.437

High

357808

QCR7
Cytochrome b-c1 complex subunit 7, mitochondrial

1

0

High-throughput

0.279

Low

585740

RRS1
Regulator of ribosome biosynthesis

1

0

High-throughput

0.269

Low

585725

TFB3
RNA polymerase II transcription factor B subunit 3

1

0

Small-scale

0.261

Low

585727

SSL1
General transcription and DNA repair factor IIH subunit SSL1

1

0

Small-scale

0.261

Low

554869

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.261

Low

585678

CLH
Clathrin heavy chain

1

0

High-throughput

0.261

Low

433414

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

441675

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

585694

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

585696

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

585732

NVJ2
Nucleus-vacuole junction protein 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025