HitPredict

Interactor 1: DNMT1 (P26358)
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)
Gene: DNMT1

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.90 0.60 0.736

The method score is based on:

Property Details
Experiments 28068325, 31130994, 35257481, 16357870, 21378168, 22094255
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005721 - pericentric heterochromatin
GO:0032259 - methylation
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1616
Hs

1 746
+ Mm
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+ At
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+ Mm
+ Hs
+ Mm
+ Zm
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+ Mm
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+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024