Protein: SL9A3
Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3)

Gene: SL9A3, SLC9A3
Organism: Homo sapiens
Interactions: 123
UniProt ID: P48764

Gene Ontology (top 5):
GO:0005769 - early endosome
GO:0005886 - plasma membrane
GO:0005903 - brush border
GO:0006811 - monoatomic ion transport
GO:0009986 - cell surface

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

877712

CHP1
Calcineurin B homologous protein 1

3

20

Small-scale

0.667

High

877711

NED4L
E3 ubiquitin-protein ligase NEDD4-like

2

1

Small-scale

0.624

High

225743

CHP2
Calcineurin B homologous protein 2

2

20

Small-scale

0.619

High

877688

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

2

6

Small-scale

0.533

High

877681

MAST2
Microtubule-associated serine/threonine-protein kinase 2

1

3

Small-scale

0.506

High

877669

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

6

Small-scale

0.501

High

877676

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

1

6

Small-scale

0.481

High

162808

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

6

Small-scale

0.479

High

631116

RAB5A
Ras-related protein Rab-5A

1

2

Small-scale

0.479

High

771628

DRD3
D(3) dopamine receptor

1

1

Small-scale

0.479

High

877667

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

0

Small-scale

0.458

High

48859

ESYT3
Extended synaptotagmin-3

1

5

High-throughput

0.445

High

61090

T131L
Transmembrane protein 131-like

1

6

High-throughput

0.445

High

175332

PLXB2
Plexin-B2

1

1

High-throughput

0.445

High

229981

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

3

High-throughput

0.445

High

243791

ADCY3
Adenylate cyclase type 3

1

3

High-throughput

0.445

High

270146

LRP3
Low-density lipoprotein receptor-related protein 3

1

7

High-throughput

0.445

High

287538

LRP6
Low-density lipoprotein receptor-related protein 6

1

5

High-throughput

0.445

High

323680

AP2A2
AP-2 complex subunit alpha-2

1

5

High-throughput

0.445

High

342791

HERC2
E3 ubiquitin-protein ligase HERC2

1

4

High-throughput

0.445

High

344649

AP2A1
AP-2 complex subunit alpha-1

1

5

High-throughput

0.445

High

410709

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

4

High-throughput

0.445

High

714590

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

2

High-throughput

0.445

High

777651

VGFR3
Vascular endothelial growth factor receptor 3

1

3

High-throughput

0.445

High

877643

VPS41
Vacuolar protein sorting-associated protein 41 homolog

1

1

High-throughput

0.445

High

877644

NUMB
Protein numb homolog

1

1

High-throughput

0.445

High

877648

PLXA3
Plexin-A3

1

1

High-throughput

0.445

High

877650

ADCY7
Adenylate cyclase type 7

1

3

High-throughput

0.445

High

877653

AP2B1
AP-2 complex subunit beta

1

5

High-throughput

0.445

High

877655

LRP2
Low-density lipoprotein receptor-related protein 2

1

5

High-throughput

0.445

High

877656

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

1

High-throughput

0.445

High

877661

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

3

High-throughput

0.445

High

877663

TMED1
Transmembrane emp24 domain-containing protein 1

1

2

High-throughput

0.445

High

877665

SCRIB
Protein scribble homolog

1

2

High-throughput

0.445

High

877670

KCNJ8
ATP-sensitive inward rectifier potassium channel 8

1

1

High-throughput

0.445

High

877671

ASTRB
Protein Aster-B

1

7

High-throughput

0.445

High

877682

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.445

High

877687

NLRX1
NLR family member X1

1

2

High-throughput

0.445

High

877693

ASPM
Abnormal spindle-like microcephaly-associated protein

1

4

High-throughput

0.445

High

877699

VANG1
Vang-like protein 1

1

3

High-throughput

0.445

High

877702

PTPRU
Receptor-type tyrosine-protein phosphatase U

1

1

High-throughput

0.445

High

877706

ASTRA
Protein Aster-A

1

7

High-throughput

0.445

High

877713

ABCA3
Phospholipid-transporting ATPase ABCA3

1

3

High-throughput

0.445

High

877715

PKP2
Plakophilin-2

1

4

High-throughput

0.445

High

877716

ESYT1
Extended synaptotagmin-1

1

5

High-throughput

0.445

High

877718

ABCA2
ATP-binding cassette sub-family A member 2

1

1

High-throughput

0.445

High

877720

CPVL
Probable serine carboxypeptidase CPVL

1

1

High-throughput

0.445

High

877721

VEZA
Vezatin

1

2

High-throughput

0.445

High

877724

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

1

High-throughput

0.445

High

877728

VANG2
Vang-like protein 2

1

3

High-throughput

0.445

High

877732

SNX14
Sorting nexin-14

1

3

High-throughput

0.445

High

877672

DCAF6
DDB1- and CUL4-associated factor 6

1

4

High-throughput

0.437

High

877704

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

6

Small-scale

0.437

High

446135

PYGL
Glycogen phosphorylase, liver form

1

0

High-throughput

0.426

High

593646

BGAL
Beta-galactosidase

1

0

High-throughput

0.426

High

877666

BLTP2
Bridge-like lipid transfer protein family member 2

1

0

High-throughput

0.426

High

877674

SNP47
Synaptosomal-associated protein 47

1

0

High-throughput

0.426

High

877719

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

High-throughput

0.426

High

60308

NBAS
NBAS subunit of NRZ tethering complex

1

2

High-throughput

0.407

High

74006

MYO9A
Unconventional myosin-IXa

1

2

High-throughput

0.407

High

175464

AREL1
Apoptosis-resistant E3 ubiquitin protein ligase 1

1

3

High-throughput

0.407

High

258249

TRI13
E3 ubiquitin-protein ligase TRIM13

1

2

High-throughput

0.407

High

291249

NU155
Nuclear pore complex protein Nup155

1

2

High-throughput

0.407

High

844244

MTHR
Methylenetetrahydrofolate reductase

1

3

High-throughput

0.407

High

877645

FXR1
RNA-binding protein FXR1

1

2

High-throughput

0.407

High

877646

FXR2
RNA-binding protein FXR2

1

2

High-throughput

0.407

High

877649

KS6A3
Ribosomal protein S6 kinase alpha-3

1

2

High-throughput

0.407

High

877651

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

2

High-throughput

0.407

High

877654

EREP3
Protein ENTREP3

1

2

High-throughput

0.407

High

877657

FMR1
Fragile X messenger ribonucleoprotein 1

1

2

High-throughput

0.407

High

877658

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

1

High-throughput

0.407

High

877659

SRBP2
Sterol regulatory element-binding protein 2

1

4

High-throughput

0.407

High

877660

SEC20
Vesicle transport protein SEC20

1

2

High-throughput

0.407

High

877662

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

1

3

High-throughput

0.407

High

877664

MYO9B
Unconventional myosin-IXb

1

3

High-throughput

0.407

High

877668

CUL7
Cullin-7

1

3

High-throughput

0.407

High

877673

TOIP1
Torsin-1A-interacting protein 1

1

1

High-throughput

0.407

High

877675

PR15B
Protein phosphatase 1 regulatory subunit 15B

1

3

High-throughput

0.407

High

877677

DCAF8
DDB1- and CUL4-associated factor 8

1

3

High-throughput

0.407

High

877678

MCTP2
Multiple C2 and transmembrane domain-containing protein 2

1

6

High-throughput

0.407

High

877680

RETST
All-trans-retinol 13,14-reductase

1

2

High-throughput

0.407

High

877683

ABH15
Protein ABHD15

1

2

High-throughput

0.407

High

877684

DHX32
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32

1

2

High-throughput

0.407

High

877686

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

1

High-throughput

0.407

High

877689

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

2

High-throughput

0.407

High

877690

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.407

High

877692

PLPL6
Patatin-like phospholipase domain-containing protein 6

1

6

High-throughput

0.407

High

877695

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.407

High

877696

LEMD2
LEM domain-containing protein 2

1

2

High-throughput

0.407

High

877697

B3GL2
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2

1

2

High-throughput

0.407

High

877698

PDZD8
PDZ domain-containing protein 8

1

3

High-throughput

0.407

High

877700

SCFD1
Sec1 family domain-containing protein 1

1

1

High-throughput

0.407

High

877701

TM131
Transmembrane protein 131

1

6

High-throughput

0.407

High

877703

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

6

High-throughput

0.407

High

877705

COA7
Cytochrome c oxidase assembly factor 7

1

3

High-throughput

0.407

High

877707

GRM2B
GRAM domain-containing protein 2B

1

7

High-throughput

0.407

High

877708

SAHH3
Adenosylhomocysteinase 3

1

3

High-throughput

0.407

High

877709

GMCL1
Germ cell-less protein-like 1

1

1

High-throughput

0.407

High

877710

DCAF5
DDB1- and CUL4-associated factor 5

1

3

High-throughput

0.407

High

877714

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

1

4

High-throughput

0.407

High

877722

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

1

2

High-throughput

0.407

High

877725

SUN2
SUN domain-containing protein 2

1

2

High-throughput

0.407

High

877727

PNMA2
Paraneoplastic antigen Ma2

1

3

High-throughput

0.407

High

877729

DHRS7
Dehydrogenase/reductase SDR family member 7

1

1

High-throughput

0.407

High

877730

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

2

High-throughput

0.407

High

877731

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.407

High

877733

NUMBL
Numb-like protein

1

1

High-throughput

0.407

High

50515

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.232

Low

140808

NOP56
Nucleolar protein 56

1

0

High-throughput

0.232

Low

327568

ELP1
Elongator complex protein 1

1

0

High-throughput

0.232

Low

337702

SGPL1
Sphingosine-1-phosphate lyase 1

1

0

High-throughput

0.232

Low

450225

HYEP
Epoxide hydrolase 1

1

0

High-throughput

0.232

Low

722907

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.232

Low

833711

KDM5C
Lysine-specific demethylase 5C

1

0

High-throughput

0.232

Low

877647

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

0

High-throughput

0.232

Low

877652

GALC
Galactocerebrosidase

1

0

High-throughput

0.232

Low

877679

RADX
RPA-related protein RADX

1

0

High-throughput

0.232

Low

877685

CP2U1
Cytochrome P450 2U1

1

0

High-throughput

0.232

Low

877691

SUGP2
SURP and G-patch domain-containing protein 2

1

0

High-throughput

0.232

Low

877694

ASCC3
Activating signal cointegrator 1 complex subunit 3

1

0

High-throughput

0.232

Low

877717

RPAP1
RNA polymerase II-associated protein 1

1

0

High-throughput

0.232

Low

877723

USE1
Vesicle transport protein USE1

1

0

High-throughput

0.232

Low

877726

ATS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025