Protein: SL9A5
Sodium/hydrogen exchanger 5 (Na(+)/H(+) exchanger 5) (NHE-5) (Solute carrier family 9 member 5)

Gene: SL9A5, SLC9A5
Organism: Homo sapiens
Interactions: 111
UniProt ID: Q14940

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion
GO:0006811 - monoatomic ion transport
GO:0015385 - sodium:proton antiporter activity
GO:0015386 - potassium:proton antiporter activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1133802

CHP1
Calcineurin B homologous protein 1

3

20

Small-scale

0.656

High

225746

CHP2
Calcineurin B homologous protein 2

2

20

Small-scale

0.585

High

732591

ARRB2
Beta-arrestin-2

1

3

Small-scale

0.573

High

225590

AAKB2
5'-AMP-activated protein kinase subunit beta-2

2

2

High-throughput

0.549

High

1095375

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

2

3

High-throughput

0.549

High

1133824

AAKB1
5'-AMP-activated protein kinase subunit beta-1

2

2

High-throughput

0.549

High

325397

DIRA1
GTP-binding protein Di-Ras1

1

2

High-throughput

0.536

High

387718

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

3

High-throughput

0.536

High

387834

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

3

High-throughput

0.536

High

387970

FIBG
Fibrinogen gamma chain

1

3

High-throughput

0.536

High

537179

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.536

High

720228

UFO
Tyrosine-protein kinase receptor UFO

1

3

High-throughput

0.536

High

889105

RBM25
RNA-binding protein 25

1

1

High-throughput

0.489

High

431811

ITB1
Integrin beta-1

1

1

Small-scale

0.479

High

882490

ARRB1
Beta-arrestin-1

1

3

Small-scale

0.479

High

60339

NBAS
NBAS subunit of NRZ tethering complex

1

2

High-throughput

0.445

High

61108

T131L
Transmembrane protein 131-like

1

6

High-throughput

0.445

High

136387

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

5

High-throughput

0.445

High

213319

ADCY6
Adenylate cyclase type 6

1

3

High-throughput

0.445

High

274876

LRP5
Low-density lipoprotein receptor-related protein 5

1

5

High-throughput

0.445

High

287560

LRP6
Low-density lipoprotein receptor-related protein 6

1

5

High-throughput

0.445

High

291337

NU155
Nuclear pore complex protein Nup155

1

2

High-throughput

0.445

High

318323

MYO1D
Unconventional myosin-Id

1

1

High-throughput

0.445

High

336670

BAG4
BAG family molecular chaperone regulator 4

1

8

High-throughput

0.445

High

347707

BAG3
BAG family molecular chaperone regulator 3

1

8

High-throughput

0.445

High

410851

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

4

High-throughput

0.445

High

600812

HSP76
Heat shock 70 kDa protein 6

1

4

High-throughput

0.445

High

617304

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

4

High-throughput

0.445

High

699750

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

4

High-throughput

0.445

High

729843

1433B
14-3-3 protein beta/alpha

1

8

High-throughput

0.445

High

761402

HS71L
Heat shock 70 kDa protein 1-like

1

4

High-throughput

0.445

High

777687

VGFR3
Vascular endothelial growth factor receptor 3

1

3

High-throughput

0.445

High

894754

EMD
Emerin

1

2

High-throughput

0.445

High

911977

DGKE
Diacylglycerol kinase epsilon

1

1

High-throughput

0.445

High

930311

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

2

High-throughput

0.445

High

933403

S12A2
Solute carrier family 12 member 2

1

3

High-throughput

0.445

High

1033979

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

1

High-throughput

0.445

High

1036979

DSC2
Desmocollin-2

1

2

High-throughput

0.445

High

1103536

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

1

3

High-throughput

0.445

High

1126264

GALT3
Polypeptide N-acetylgalactosaminyltransferase 3

1

5

High-throughput

0.445

High

1129946

MELK
Maternal embryonic leucine zipper kinase

1

4

High-throughput

0.445

High

1133773

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

1

High-throughput

0.445

High

1133777

ATD3B
ATPase family AAA domain-containing protein 3B

1

3

High-throughput

0.445

High

1133779

RNF43
E3 ubiquitin-protein ligase RNF43

1

6

High-throughput

0.445

High

1133780

RETST
All-trans-retinol 13,14-reductase

1

2

High-throughput

0.445

High

1133782

LRIG3
Leucine-rich repeats and immunoglobulin-like domains protein 3

1

3

High-throughput

0.445

High

1133783

ABH15
Protein ABHD15

1

2

High-throughput

0.445

High

1133788

RELL1
RELT-like protein 1

1

2

High-throughput

0.445

High

1133789

PLPL6
Patatin-like phospholipase domain-containing protein 6

1

6

High-throughput

0.445

High

1133791

PDZD8
PDZ domain-containing protein 8

1

3

High-throughput

0.445

High

1133792

VANG1
Vang-like protein 1

1

3

High-throughput

0.445

High

1133794

S20A1
Sodium-dependent phosphate transporter 1

1

1

High-throughput

0.445

High

1133796

TR19L
Tumor necrosis factor receptor superfamily member 19L

1

2

High-throughput

0.445

High

1133797

ASTRA
Protein Aster-A

1

7

High-throughput

0.445

High

1133801

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

1

3

High-throughput

0.445

High

1133804

CCDC8
Coiled-coil domain-containing protein 8

1

3

High-throughput

0.445

High

1133806

MARH7
E3 ubiquitin-protein ligase MARCHF7

1

1

High-throughput

0.445

High

1133807

MYO10
Unconventional myosin-X

1

1

High-throughput

0.445

High

1133808

WDR6
tRNA

1

1

High-throughput

0.445

High

1133812

LIMA1
LIM domain and actin-binding protein 1

1

1

High-throughput

0.445

High

1133814

BAG5
BAG family molecular chaperone regulator 5

1

8

High-throughput

0.445

High

1133817

VANG2
Vang-like protein 2

1

3

High-throughput

0.445

High

1133818

ZNRF3
E3 ubiquitin-protein ligase ZNRF3

1

7

High-throughput

0.445

High

1133820

S12A4
Solute carrier family 12 member 4

1

2

High-throughput

0.445

High

1133822

NISCH
Nischarin

1

2

High-throughput

0.445

High

839012

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

0

High-throughput

0.426

High

877114

KC1D
Casein kinase I isoform delta

1

0

High-throughput

0.426

High

1133813

MA1B1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

1

0

High-throughput

0.426

High

1133823

TBC30
TBC1 domain family member 30

1

0

High-throughput

0.426

High

1133826

S4A7
Sodium bicarbonate cotransporter 3

1

0

High-throughput

0.426

High

175470

AREL1
Apoptosis-resistant E3 ubiquitin protein ligase 1

1

3

High-throughput

0.407

High

230025

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

3

High-throughput

0.407

High

258287

TRI13
E3 ubiquitin-protein ligase TRIM13

1

2

High-throughput

0.407

High

272183

OBSL1
Obscurin-like protein 1

1

1

High-throughput

0.407

High

625385

CSK22
Casein kinase II subunit alpha'

1

3

High-throughput

0.407

High

844254

MTHR
Methylenetetrahydrofolate reductase

1

3

High-throughput

0.407

High

930699

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

3

High-throughput

0.407

High

946107

MLF1
Myeloid leukemia factor 1

1

1

High-throughput

0.407

High

995038

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.407

High

1091924

SEC20
Vesicle transport protein SEC20

1

2

High-throughput

0.407

High

1133775

TM201
Transmembrane protein 201

1

2

High-throughput

0.407

High

1133776

PR15B
Protein phosphatase 1 regulatory subunit 15B

1

3

High-throughput

0.407

High

1133781

PKN3
Serine/threonine-protein kinase N3

1

1

High-throughput

0.407

High

1133784

DHX32
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32

1

2

High-throughput

0.407

High

1133785

PKHH3
Pleckstrin homology domain-containing family H member 3

1

1

High-throughput

0.407

High

1133786

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

2

High-throughput

0.407

High

1133787

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

5

High-throughput

0.407

High

1133790

CHSS2
Chondroitin sulfate synthase 2

1

3

High-throughput

0.407

High

1133795

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

4

High-throughput

0.407

High

1133798

P121A
Nuclear envelope pore membrane protein POM 121

1

2

High-throughput

0.407

High

1133799

SAHH3
Adenosylhomocysteinase 3

1

3

High-throughput

0.407

High

1133800

GMCL1
Germ cell-less protein-like 1

1

1

High-throughput

0.407

High

1133803

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

1

4

High-throughput

0.407

High

1133805

DJC18
DnaJ homolog subfamily C member 18

1

14

High-throughput

0.407

High

1133809

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

1

2

High-throughput

0.407

High

1133811

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

2

High-throughput

0.407

High

1133816

ATD2B
ATPase family AAA domain-containing protein 2B

1

1

High-throughput

0.407

High

1133819

CHIP
E3 ubiquitin-protein ligase CHIP

1

4

High-throughput

0.407

High

1133821

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

1

1

High-throughput

0.407

High

1133825

SNX14
Sorting nexin-14

1

3

High-throughput

0.407

High

992756

RACK1
Small ribosomal subunit protein RACK1

1

0

Small-scale

0.299

High

808067

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.279

Low

911835

GDS1
Rap1 GTPase-GDP dissociation stimulator 1

1

0

High-throughput

0.279

Low

977700

ACTA
Actin, aortic smooth muscle

1

0

High-throughput

0.279

Low

999351

HBB
Hemoglobin subunit beta

1

0

High-throughput

0.279

Low

1133774

ECM1
Extracellular matrix protein 1

1

0

High-throughput

0.279

Low

760829

GLYC
Serine hydroxymethyltransferase, cytosolic

1

0

High-throughput

0.232

Low

1133778

CAHD1
VWFA and cache domain-containing protein 1

1

0

High-throughput

0.232

Low

1133793

WDR48
WD repeat-containing protein 48

1

0

High-throughput

0.232

Low

1133810

TRM7
tRNA

1

0

High-throughput

0.232

Low

1133815

MKLN1
Muskelin

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025