HitPredict

Interactor 1: HMGB2 (P26583)
High mobility group protein B2 (High mobility group protein 2) (HMG-2)
Gene: HMGB2

Interactor 2: UHRF2 (Q96PU4)
E3 ubiquitin-protein ligase UHRF2 (EC 2.3.2.27) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear protein 97) (Nuclear zinc finger protein Np97) (RING finger protein 107) (RING-type E3 ubiquitin transferase UHRF2) (Ubiquitin-like PHD and RING finger domain-containing protein 2) (Ubiquitin-like-containing PHD and RING finger domains protein 2)
Gene: UHRF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	31694235
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 209 Hs			1 802
+	Hs
		449797 HMGB1_HUMAN (1-174): 3.53e-42: 143: 86.21		UHRF2_HUMAN (1-802): 0: 964: 100.00
+	Hs
		996841 SSRP1_HUMAN (5-84): 2.82e-09: 57.9: 35.00		UHRF2_HUMAN (1-802): 0: 964: 100.00
+	Hs
		996851 SSRP1_HUMAN (5-84): 2.82e-09: 57.9: 35.00		UHRF1_HUMAN (1-802): 0: 817: 53.01
+	Hs
		727736 SOX5_HUMAN (20-169): 8.6e-30: 117: 23.33		CHD3_HUMAN (234-595): 1.54e-60: 225: 12.31
+	Hs
		817986 SOX2_HUMAN (3-94): 2.29e-23: 96.7: 22.83		CHD3_HUMAN (234-595): 1.54e-60: 225: 12.31
+	Hs
		818056 SOX2_HUMAN (3-94): 2.29e-23: 96.7: 22.83		CHD4_HUMAN (294-594): 1.5e-54: 207: 12.84
+	Hs
		567686 UBF1_HUMAN (10-158): 1.47e-09: 58.9: 24.72		CHD3_HUMAN (234-595): 1.54e-60: 225: 12.31
+	Hs
		996636 SSRP1_HUMAN (5-84): 2.82e-09: 57.9: 35.00		CHD3_HUMAN (234-595): 1.54e-60: 225: 12.31
+	Hs
		1059807 CIC_HUMAN (3-100): 1.66e-11: 64.7: 22.45		CHD4_HUMAN (294-594): 1.5e-54: 207: 12.84
+	Hs
		567697 UBF1_HUMAN (10-158): 1.47e-09: 58.9: 24.72		CHD4_HUMAN (294-594): 1.5e-54: 207: 12.84
+	Hs
		297467 TOX4_HUMAN (91-170): 1.08e-31: 122: 33.75		KDM5C_HUMAN (251-428): 3.26e-34: 143: 16.36
+	Hs
		996673 SSRP1_HUMAN (5-84): 2.82e-09: 57.9: 35.00		CHD4_HUMAN (294-594): 1.5e-54: 207: 12.84
+	Hs
		152602 SOX5_HUMAN (20-169): 8.6e-30: 117: 23.33		KMT2D_HUMAN (340-394): 7.58e-10: 65.3: 30.36
+	Hs
		1243837 SOX7_HUMAN (3-90): 2.58e-23: 97.5: 23.86		KMT2C_HUMAN (340-393): 5.02e-10: 65.6: 34.55
+	Hs
		1243843 SOX17_HUMAN (6-90): 3.84e-23: 97.5: 22.35		KMT2C_HUMAN (340-393): 5.02e-10: 65.6: 34.55
+	Hs
		152684 SOX7_HUMAN (3-90): 2.58e-23: 97.5: 23.86		KMT2D_HUMAN (340-394): 7.58e-10: 65.3: 30.36
+	Hs
		152690 SOX17_HUMAN (6-90): 3.84e-23: 97.5: 22.35		KMT2D_HUMAN (340-394): 7.58e-10: 65.3: 30.36
+	Hs
		818266 SOX2_HUMAN (3-94): 2.29e-23: 96.7: 22.83		KMT2C_HUMAN (340-393): 5.02e-10: 65.6: 34.55
+	Hs
		152610 SOX2_HUMAN (3-94): 2.29e-23: 96.7: 22.83		KMT2D_HUMAN (340-394): 7.58e-10: 65.3: 30.36
+	Hs
		152619 SOX10_HUMAN (2-98): 5.81e-22: 94.4: 16.50		KMT2D_HUMAN (340-394): 7.58e-10: 65.3: 30.36