Protein: OSBL3
Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3)

Gene: OSBL3, OSBPL3
Organism: Homo sapiens
Interactions: 124
UniProt ID: Q9H4L5

Gene Ontology (top 5):
GO:0005789 - endoplasmic reticulum membrane
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006699 - bile acid biosynthetic process
GO:0015485 - cholesterol binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

333201

VAPB
Vesicle-associated membrane protein-associated protein B/C

7

20

Small-scale

0.744

High

966872

1433G
14-3-3 protein gamma

6

20

High-throughput

0.736

High

730241

1433B
14-3-3 protein beta/alpha

6

20

High-throughput

0.730

High

1433831

VAPA
Vesicle-associated membrane protein-associated protein A

5

20

High-throughput

0.720

High

1049783

1433F
14-3-3 protein eta

5

20

High-throughput

0.716

High

170353

AURKA
Aurora kinase A

4

4

High-throughput

0.694

High

1419830

OSBL7
Oxysterol-binding protein-related protein 7

1

12

High-throughput

0.691

High

1327841

ARRD1
Arrestin domain-containing protein 1

4

1

High-throughput

0.691

High

691430

1433T
14-3-3 protein theta

4

20

High-throughput

0.687

High

1433829

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

3

1

High-throughput

0.667

High

327449

ZFPL1
Zinc finger protein-like 1

3

3

High-throughput

0.662

High

990730

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.662

High

1387271

HDA11
Histone deacetylase 11

3

2

High-throughput

0.662

High

1390817

CPNE2
Copine-2

3

0

High-throughput

0.634

High

50694

HACL2
2-hydroxyacyl-CoA lyase 2

2

2

High-throughput

0.628

High

230663

PRIC3
Prickle planar cell polarity protein 3

2

3

High-throughput

0.628

High

1093954

TRAF1
TNF receptor-associated factor 1

2

1

High-throughput

0.628

High

1395077

JPH4
Junctophilin-4

2

2

High-throughput

0.628

High

1433830

NOP53
Ribosome biogenesis protein NOP53

2

1

High-throughput

0.628

High

1419834

OSBL6
Oxysterol-binding protein-related protein 6

1

12

High-throughput

0.618

High

971998

1433E
14-3-3 protein epsilon

2

2

High-throughput

0.611

High

136134

PLK4
Serine/threonine-protein kinase PLK4

2

4

High-throughput

0.606

High

624525

WT1
Wilms tumor protein

2

1

High-throughput

0.606

High

952344

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

2

12

High-throughput

0.606

High

1293243

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

2

1

High-throughput

0.606

High

1430326

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

2

12

High-throughput

0.606

High

1145367

RNPS1
RNA-binding protein with serine-rich domain 1

2

1

High-throughput

0.601

High

978304

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

215186

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

2

0

High-throughput

0.580

High

985883

RL11
Large ribosomal subunit protein uL5

2

0

High-throughput

0.580

High

1051423

ZBT16
Zinc finger and BTB domain-containing protein 16

2

0

High-throughput

0.580

High

1118991

BYST
Bystin

2

0

High-throughput

0.580

High

1185325

F161A
Protein FAM161A

2

0

High-throughput

0.580

High

1385441

SYTL4
Synaptotagmin-like protein 4

2

0

High-throughput

0.580

High

1433836

T3JAM
TRAF3-interacting JNK-activating modulator

2

0

High-throughput

0.580

High

1433832

ARP3B
Actin-related protein 3B

2

1

High-throughput

0.574

High

1150178

TCEA2
Transcription elongation factor A protein 2

2

1

High-throughput

0.553

High

1331102

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

2

1

High-throughput

0.553

High

1348502

LNX1
E3 ubiquitin-protein ligase LNX

2

2

High-throughput

0.553

High

1351625

STK35
Serine/threonine-protein kinase 35

2

3

High-throughput

0.553

High

1015308

ERH
Enhancer of rudimentary homolog

2

1

High-throughput

0.549

High

1098940

KLRD1
Natural killer cells antigen CD94

1

3

High-throughput

0.536

High

1307927

ARMC8
Armadillo repeat-containing protein 8

1

1

High-throughput

0.536

High

1325341

PHTF2
Protein PHTF2

1

1

High-throughput

0.536

High

1370534

FGF13
Fibroblast growth factor 13

1

1

High-throughput

0.536

High

1383855

EFMT3
EEF1A lysine methyltransferase 3

1

2

High-throughput

0.536

High

1419488

PITM3
Membrane-associated phosphatidylinositol transfer protein 3

1

2

High-throughput

0.536

High

1433826

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.536

High

730888

1433S
14-3-3 protein sigma

1

20

High-throughput

0.515

High

445259

S10A6
Protein S100-A6

1

0

High-throughput

0.513

High

1120551

NID2
Nidogen-2

1

0

High-throughput

0.513

High

1130185

SMC1A
Structural maintenance of chromosomes protein 1A

1

0

High-throughput

0.513

High

1143939

2A5B
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

1

0

High-throughput

0.513

High

1249789

ELAP1
Endosome/lysosome-associated apoptosis and autophagy regulator 1

1

0

High-throughput

0.513

High

1326904

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.513

High

384549

CRYAA
Alpha-crystallin A chain

1

3

High-throughput

0.501

High

1370580

FGF11
Fibroblast growth factor 11

1

1

High-throughput

0.489

High

1433835

ABT1
Activator of basal transcription 1

1

2

High-throughput

0.489

High

375953

RASK
GTPase KRas

1

13

High-throughput

0.479

High

401475

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

466460

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

581290

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

611349

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

3

High-throughput

0.479

High

786850

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

2

High-throughput

0.479

High

953673

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

962483

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

988707

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

1015785

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

1067718

EP300
Histone acetyltransferase p300

1

3

High-throughput

0.479

High

1138058

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

1140858

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.479

High

1380750

RL36L
Ribosomal protein eL42-like

1

1

High-throughput

0.479

High

1428353

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

12

Small-scale

0.479

High

1433505

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

1433825

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.479

High

1433838

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.479

High

1433839

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

2

Small-scale

0.479

High

1433840

KCTD3
BTB/POZ domain-containing protein KCTD3

1

3

High-throughput

0.479

High

129426

MEN1
Menin

1

0

High-throughput

0.458

High

630039

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

980317

H4
Histone H4

1

0

High-throughput

0.458

High

1107672

MTM1
Myotubularin

1

0

High-throughput

0.458

High

1141935

EEA1
Early endosome antigen 1

1

0

High-throughput

0.458

High

1208575

SMAG2
Protein Smaug homolog 2

1

0

High-throughput

0.458

High

1270422

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

Small-scale

0.458

High

255213

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.445

High

337816

SGPL1
Sphingosine-1-phosphate lyase 1

1

1

High-throughput

0.445

High

872024

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

1

High-throughput

0.445

High

877233

KC1D
Casein kinase I isoform delta

1

1

High-throughput

0.445

High

1131616

MFS10
Major facilitator superfamily domain-containing protein 10

1

3

High-throughput

0.445

High

1258580

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

1

High-throughput

0.445

High

1346788

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

6

High-throughput

0.445

High

1350070

SPP2B
Signal peptide peptidase-like 2B

1

3

High-throughput

0.445

High

1433833

TBK1
Serine/threonine-protein kinase TBK1

1

2

Small-scale

0.445

High

106652

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

696500

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.437

High

1255535

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.437

High

1291581

HOOK3
Protein Hook homolog 3

1

1

High-throughput

0.437

High

1433828

OTULL
Inactive ubiquitin thioesterase OTULINL

1

6

High-throughput

0.437

High

1433834

XPO7
Exportin-7

1

2

High-throughput

0.437

High

279496

TULP3
Tubby-related protein 3

1

0

High-throughput

0.426

High

1023886

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.426

High

1416815

C1QT1
Complement C1q tumor necrosis factor-related protein 1

1

0

High-throughput

0.426

High

1433841

SNX8
Sorting nexin-8

1

0

High-throughput

0.426

High

1239420

TTI2
TELO2-interacting protein 2

3

0

High-throughput

0.345

High

1430541

TSYL1
Testis-specific Y-encoded-like protein 1

3

0

High-throughput

0.345

High

1065884

ACSM1
Acyl-coenzyme A synthetase ACSM1, mitochondrial

2

0

High-throughput

0.316

High

1213253

ZN648
Zinc finger protein 648

2

0

High-throughput

0.316

High

1253123

ZN497
Zinc finger protein 497

2

0

High-throughput

0.316

High

1390164

MCRS1
Microspherule protein 1

2

0

High-throughput

0.316

High

1398580

ZNF48
Zinc finger protein 48

2

0

High-throughput

0.316

High

1406155

PRP18
Pre-mRNA-splicing factor 18

2

0

High-throughput

0.316

High

1433837

ZN835
Zinc finger protein 835

2

0

High-throughput

0.316

High

503659

TFPT
TCF3 fusion partner

1

0

High-throughput

0.279

Low

1356137

THAP3
THAP domain-containing protein 3

1

0

High-throughput

0.279

Low

1382701

EMID1
EMI domain-containing protein 1

1

0

High-throughput

0.279

Low

615197

PACA
Pituitary adenylate cyclase-activating polypeptide

1

0

High-throughput

0.249

Low

1332894

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

1352753

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.249

Low

1433827

SP110
Sp110 nuclear body protein

1

0

High-throughput

0.249

Low

584145

FOSL2
Fos-related antigen 2

1

0

High-throughput

0.232

Low

912231

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

0

High-throughput

0.232

Low

1030813

DEF5
Defensin alpha 5

1

0

High-throughput

0.232

Low

1337416

SRFB1
Serum response factor-binding protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025