Protein: SPAG5
Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126)

Gene: SPAG5
Organism: Homo sapiens
Interactions: 195
UniProt ID: Q96R06

Gene Ontology (top 5):
GO:0000070 - mitotic sister chromatid segregation
GO:0000776 - kinetochore
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0007051 - spindle organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1350705

CCHCR
Coiled-coil alpha-helical rod protein 1

4

19

High-throughput

0.698

High

991680

DYL1
Dynein light chain 1, cytoplasmic

4

4

High-throughput

0.697

High

1053428

DEUP1
Deuterosome assembly protein 1

4

19

High-throughput

0.694

High

1152212

MARE1
Microtubule-associated protein RP/EB family member 1

4

5

Small-scale

0.694

High

920209

PLK1
Serine/threonine-protein kinase PLK1

4

5

Small-scale

0.686

High

212782

SRGP3
SLIT-ROBO Rho GTPase-activating protein 3

3

12

High-throughput

0.667

High

1401176

IFT57
Intraflagellar transport protein 57 homolog

4

0

High-throughput

0.661

High

1210960

CE170
Centrosomal protein of 170 kDa

3

20

High-throughput

0.656

High

1390698

DYL2
Dynein light chain 2, cytoplasmic

3

4

High-throughput

0.650

High

50927

SYCE3
Synaptonemal complex central element protein 3

3

0

High-throughput

0.634

High

1238579

RINT1
RAD50-interacting protein 1

3

0

High-throughput

0.634

High

257169

CCD22
Coiled-coil domain-containing protein 22

2

20

High-throughput

0.628

High

1331744

CCD89
Coiled-coil domain-containing protein 89

2

9

High-throughput

0.628

High

1350263

RHPN1
Rhophilin-1

2

6

High-throughput

0.628

High

1401168

CSN7B
COP9 signalosome complex subunit 7b

2

1

High-throughput

0.628

High

1401164

CENPH
Centromere protein H

3

0

High-throughput

0.620

High

1349651

PPL13
Placental protein 13-like

3

7

High-throughput

0.616

High

273091

CLU
Clustered mitochondria protein homolog

2

4

High-throughput

0.611

High

1401174

DISC1
Disrupted in schizophrenia 1 protein

2

4

High-throughput

0.606

High

136124

PLK4
Serine/threonine-protein kinase PLK4

2

19

High-throughput

0.606

High

341839

K2C75
Keratin, type II cytoskeletal 75

2

11

High-throughput

0.606

High

551585

K2C3
Keratin, type II cytoskeletal 3

2

13

High-throughput

0.606

High

933881

GEM
GTP-binding protein GEM

2

5

High-throughput

0.606

High

1157488

PKN1
Serine/threonine-protein kinase N1

2

9

High-throughput

0.606

High

1108853

BFSP2
Phakinin

3

20

High-throughput

0.604

High

1401185

TSKS
Testis-specific serine kinase substrate

2

0

High-throughput

0.602

High

1401195

ORC6
Origin recognition complex subunit 6

2

0

High-throughput

0.601

High

1143486

PCM1
Pericentriolar material 1 protein

2

2

Small-scale

0.594

High

1389785

DTBP1
Dysbindin

2

0

High-throughput

0.585

High

891749

GSK3B
Glycogen synthase kinase-3 beta

2

20

High-throughput

0.584

High

1123775

DCTN1
Dynactin subunit 1

2

18

High-throughput

0.584

High

1401151

MYCBP
c-Myc-binding protein

2

0

High-throughput

0.576

High

1401162

TSYL1
Testis-specific Y-encoded-like protein 1

2

3

High-throughput

0.574

High

1401196

EMIL1
EMILIN-1

2

14

High-throughput

0.574

High

983692

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

1

High-throughput

0.573

High

1294640

CD20B
Cell division cycle protein 20 homolog B

1

14

High-throughput

0.573

High

1379997

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

5

High-throughput

0.573

High

1401166

SH24A
SH2 domain-containing protein 4A

1

14

High-throughput

0.573

High

1401191

AMOL2
Angiomotin-like protein 2

1

17

High-throughput

0.573

High

1228459

FTM
Protein fantom

2

20

High-throughput

0.571

High

186578

TRI18
E3 ubiquitin-protein ligase Midline-1

1

20

Small-scale

0.561

High

1401186

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

19

Small-scale

0.561

High

302202

NEBL
Nebulette

2

20

High-throughput

0.553

High

1277120

ZN572
Zinc finger protein 572

2

4

High-throughput

0.553

High

1290363

IGFN1
Immunoglobulin-like and fibronectin type III domain-containing protein 1

2

20

High-throughput

0.553

High

1392782

P121A
Nuclear envelope pore membrane protein POM 121

2

17

High-throughput

0.553

High

51482

FSD2
Fibronectin type III and SPRY domain-containing protein 2

2

20

High-throughput

0.549

High

1401153

KXDL1
KxDL motif-containing protein 1

2

1

High-throughput

0.549

High

221283

DCX
Neuronal migration protein doublecortin

1

0

High-throughput

0.549

High

252143

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.549

High

1276094

KANL1
KAT8 regulatory NSL complex subunit 1

1

0

High-throughput

0.549

High

1386272

HAUS1
HAUS augmin-like complex subunit 1

1

0

High-throughput

0.549

High

1401175

FBX28
F-box only protein 28

1

0

High-throughput

0.549

High

1401177

AIRIM
AFG2-interacting ribosome maturation factor

1

0

High-throughput

0.549

High

333392

SNAPN
SNARE-associated protein Snapin

1

4

High-throughput

0.541

High

1364975

TSC1
Hamartin

1

20

High-throughput

0.541

High

1401157

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

11

High-throughput

0.541

High

1401169

ARNT2
Aryl hydrocarbon receptor nuclear translocator 2

1

12

High-throughput

0.541

High

300684

KRT37
Keratin, type I cuticular Ha7

1

20

High-throughput

0.536

High

300819

KRT38
Keratin, type I cuticular Ha8

1

20

High-throughput

0.536

High

643389

OSBP1
Oxysterol-binding protein 1

1

2

High-throughput

0.536

High

698349

MAP4
Microtubule-associated protein 4

1

20

High-throughput

0.536

High

990630

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

997470

TBB4B
Tubulin beta-4B chain

1

3

High-throughput

0.536

High

1091031

BFSP1
Filensin

1

20

High-throughput

0.536

High

1277613

K1C27
Keratin, type I cytoskeletal 27

1

15

High-throughput

0.536

High

1278209

CLAP1
CLIP-associating protein 1

1

5

Small-scale

0.536

High

1322131

SYCE1
Synaptonemal complex central element protein 1

1

2

High-throughput

0.536

High

1397235

LURA1
Leucine rich adaptor protein 1

1

2

High-throughput

0.536

High

1401156

DUS16
Dual specificity protein phosphatase 16

1

12

High-throughput

0.536

High

1401159

K1C23
Keratin, type I cytoskeletal 23

1

17

High-throughput

0.536

High

1401165

RABE2
Rab GTPase-binding effector protein 2

1

18

High-throughput

0.536

High

1401171

RIC8A
Chaperone Ric-8A

1

1

High-throughput

0.536

High

1401179

ABI2
Abl interactor 2

1

20

High-throughput

0.536

High

1401158

OSBL8
Oxysterol-binding protein-related protein 8

1

2

Small-scale

0.529

High

1220034

TTC23
Tetratricopeptide repeat protein 23

1

2

High-throughput

0.523

High

1224705

TSH3
Teashirt homolog 3

1

13

High-throughput

0.523

High

1390494

LIGO1
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

1

6

High-throughput

0.523

High

1394540

RBM41
RNA-binding protein 41

1

13

High-throughput

0.523

High

1401154

PIMRE
Protein PIMREG

1

0

High-throughput

0.518

High

1178866

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.513

High

1313686

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.513

High

1401194

SKAP
Small kinetochore-associated protein

1

0

High-throughput

0.513

High

928325

ATN1
Atrophin-1

1

12

High-throughput

0.508

High

1228886

ZFY26
Zinc finger FYVE domain-containing protein 26

1

20

High-throughput

0.508

High

170295

AURKA
Aurora kinase A

1

20

Small-scale

0.506

High

443482

CDK1
Cyclin-dependent kinase 1

1

15

Small-scale

0.501

High

1401167

DCR1B
5' exonuclease Apollo

1

1

Small-scale

0.501

High

1322632

RPTOR
Regulatory-associated protein of mTOR

1

20

Small-scale

0.500

High

1401150

CK5P2
CDK5 regulatory subunit-associated protein 2

1

18

Small-scale

0.500

High

903236

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

18

High-throughput

0.494

High

1234672

IQCE
IQ domain-containing protein E

1

18

High-throughput

0.494

High

887456

CEBPD
CCAAT/enhancer-binding protein delta

1

10

Small-scale

0.489

High

1142149

P2RY6
P2Y purinoceptor 6

1

4

High-throughput

0.489

High

1151282

MED1
Mediator of RNA polymerase II transcription subunit 1

1

14

High-throughput

0.489

High

1194527

SL9C1
Solute carrier family 9 member C1

1

4

High-throughput

0.489

High

1323281

KT222
Keratin-like protein KRT222

1

20

High-throughput

0.489

High

1395382

NEUL4
Neuralized-like protein 4

1

2

High-throughput

0.489

High

1397799

ODAD1
Outer dynein arm-docking complex subunit 1

1

20

High-throughput

0.489

High

1401155

AN30A
Ankyrin repeat domain-containing protein 30A

1

12

High-throughput

0.489

High

1401161

ENKD1
Enkurin domain-containing protein 1

1

0

High-throughput

0.486

High

1056917

FMR1
Fragile X messenger ribonucleoprotein 1

1

6

High-throughput

0.481

High

1401152

BARD1
BRCA1-associated RING domain protein 1

1

11

High-throughput

0.481

High

122542

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

1

High-throughput

0.479

High

138279

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

5

High-throughput

0.479

High

164061

NDC80
Kinetochore protein NDC80 homolog

1

18

High-throughput

0.479

High

247412

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

12

High-throughput

0.479

High

290117

OFD1
Centriole and centriolar satellite protein OFD1

1

1

High-throughput

0.479

High

436978

K1C18
Keratin, type I cytoskeletal 18

1

18

High-throughput

0.479

High

437310

K2C8
Keratin, type II cytoskeletal 8

1

11

High-throughput

0.479

High

459727

PROF1
Profilin-1

1

3

High-throughput

0.479

High

468709

HS90B
Heat shock protein HSP 90-beta

1

11

High-throughput

0.479

High

475667

K1C19
Keratin, type I cytoskeletal 19

1

16

High-throughput

0.479

High

786796

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

18

High-throughput

0.479

High

799414

BRCA1
Breast cancer type 1 susceptibility protein

1

20

High-throughput

0.479

High

831274

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

891293

GSK3A
Glycogen synthase kinase-3 alpha

1

18

High-throughput

0.479

High

896617

VASP
Vasodilator-stimulated phosphoprotein

1

4

High-throughput

0.479

High

930021

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

11

Small-scale

0.479

High

986650

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

6

High-throughput

0.479

High

1067619

EP300
Histone acetyltransferase p300

1

19

High-throughput

0.479

High

1095295

REST
RE1-silencing transcription factor

1

5

High-throughput

0.479

High

1110007

HDAC1
Histone deacetylase 1

1

20

High-throughput

0.479

High

1110695

DCTN2
Dynactin subunit 2

1

1

High-throughput

0.479

High

1114066

CUL3
Cullin-3

1

19

High-throughput

0.479

High

1138530

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

8

High-throughput

0.479

High

1140721

KIF14
Kinesin-like protein KIF14

1

16

High-throughput

0.479

High

1156188

ZYX
Zyxin

1

5

High-throughput

0.479

High

1193465

CCD14
Coiled-coil domain-containing protein 14

1

1

High-throughput

0.479

High

1197066

AMOT
Angiomotin

1

20

High-throughput

0.479

High

1214556

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

1

High-throughput

0.479

High

1248179

SAS6
Spindle assembly abnormal protein 6 homolog

1

19

High-throughput

0.479

High

1252187

SYNE3
Nesprin-3

1

20

High-throughput

0.479

High

1252940

BAKOR
Beclin 1-associated autophagy-related key regulator

1

1

High-throughput

0.479

High

1255151

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1289553

NAA40
N-alpha-acetyltransferase 40

1

5

High-throughput

0.479

High

1291564

HOOK3
Protein Hook homolog 3

1

19

High-throughput

0.479

High

1322429

SPICE
Spindle and centriole-associated protein 1

1

1

High-throughput

0.479

High

1326316

NIN
Ninein

1

19

High-throughput

0.479

High

1360803

ASB11
Ankyrin repeat and SOCS box protein 11

1

9

High-throughput

0.479

High

1391714

AURKB
Aurora kinase B

1

20

Small-scale

0.479

High

1401172

TRI36
E3 ubiquitin-protein ligase TRIM36

1

20

High-throughput

0.479

High

1401173

ANLN
Anillin

1

13

High-throughput

0.479

High

1401182

CEP72
Centrosomal protein of 72 kDa

1

10

Small-scale

0.479

High

1401184

HECW2
E3 ubiquitin-protein ligase HECW2

1

5

High-throughput

0.479

High

1401187

ANC2
Anaphase-promoting complex subunit 2

1

20

High-throughput

0.479

High

1401188

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

6

High-throughput

0.479

High

1401189

MARE3
Microtubule-associated protein RP/EB family member 3

1

5

High-throughput

0.479

High

1401190

NINL
Ninein-like protein

1

18

High-throughput

0.479

High

48314

A0AVN2
BRCA1-associated RING domain protein 1

1

15

High-throughput

0.470

High

108039

G3V1X1
Proline/serine-rich coiled-coil 2, isoform CRA_a

1

2

High-throughput

0.470

High

1068826

GOG8D
Putative golgin subfamily A member 8D

1

17

High-throughput

0.470

High

1327446

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

1

High-throughput

0.464

High

278942

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.458

High

1177995

MOONR
Protein moonraker

1

0

High-throughput

0.458

High

1401160

CEP44
Centrosomal protein of 44 kDa

1

0

High-throughput

0.458

High

1313082

Q8IXW7
FMR1 protein

1

6

High-throughput

0.457

High

1401197

X5DP31
Aryl hydrocarbon receptor nuclear translocator 2

1

12

High-throughput

0.457

High

530247

TAU
Microtubule-associated protein tau

1

19

High-throughput

0.445

High

1227303

A16L1
Autophagy-related protein 16-1

1

16

High-throughput

0.445

High

1401183

ABI3
ABI gene family member 3

1

18

High-throughput

0.445

High

244760

ZC3H1
Zinc finger C3H1 domain-containing protein

1

2

High-throughput

0.439

High

505759

ZN688
Zinc finger protein 688

1

4

High-throughput

0.439

High

250005

OGA
Protein O-GlcNAcase

1

0

High-throughput

0.438

High

218653

TGON2
Trans-Golgi network integral membrane protein 2

1

13

High-throughput

0.437

High

246881

KDM1A
Lysine-specific histone demethylase 1A

1

7

High-throughput

0.437

High

353513

AGR2
Anterior gradient protein 2 homolog

1

7

High-throughput

0.437

High

768944

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.437

High

1249136

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1276670

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.437

High

1384418

PF21A
PHD finger protein 21A

1

20

High-throughput

0.437

High

1401170

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.437

High

1401181

SEP10
Septin-10

1

3

High-throughput

0.437

High

3560

A0A0S2Z5X4
Zinc finger protein 688 isoform 4

1

3

High-throughput

0.417

High

1105823

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

4

Small-scale

0.417

High

683320

TNR5
Tumor necrosis factor receptor superfamily member 5

1

5

High-throughput

0.407

High

1167103

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

1

High-throughput

0.407

High

1187269

C144B
Putative coiled-coil domain-containing protein 144B

1

19

High-throughput

0.407

High

1329299

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

1

1

High-throughput

0.407

High

1340230

MSPD2
Motile sperm domain-containing protein 2

1

4

High-throughput

0.407

High

1396564

C170L
Cep170-like protein

1

3

High-throughput

0.407

High

1401192

S27A6
Long-chain fatty acid transport protein 6

1

1

High-throughput

0.407

High

1392327

BORC6
BLOC-1-related complex subunit 6

4

0

High-throughput

0.362

High

1108386

MED21
Mediator of RNA polymerase II transcription subunit 21

3

0

High-throughput

0.345

High

60739

F234B
Protein FAM234B

2

0

High-throughput

0.328

High

1401193

COG6
Conserved oligomeric Golgi complex subunit 6

2

0

High-throughput

0.328

High

1401163

UN93B
Protein unc-93 homolog B1

2

0

High-throughput

0.313

High

1198841

ZC21C
Zinc finger C2HC domain-containing protein 1C

1

0

High-throughput

0.299

High

1210096

SNP47
Synaptosomal-associated protein 47

1

0

High-throughput

0.299

High

1398942

ZMAT2
Zinc finger matrin-type protein 2

1

0

High-throughput

0.299

High

1401178

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.299

High

1393533

MR1L1
MORF4 family-associated protein 1-like 1

1

0

High-throughput

0.279

Low

1401180

NLGN3
Neuroligin-3

1

0

Small-scale

0.265

Low

1328392

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low

1226437

Z385C
Zinc finger protein 385C

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025