HitPredict

Interactor 1: PUR2 (P22102)
Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)]
Gene: GART

Interactor 2: PUR2 (P22102)
Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)]
Gene: GART

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.56 1.00 0.754

The method score is based on:

Property Details
Experiments 39358380, 31839598
Identification Methods cross-linking study
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains AIRS~AIRS, AIRS~AIRS_C, AIRS_C~AIRS_C, Formyl_trans_N~Formyl_trans_N, GARS_A~GARS_A, GARS_A~GARS_C, GARS_A~GARS_N, GARS_C~GARS_N, GARS_N~GARS_N
Common GO terms GO:0003360 - brainstem development
GO:0004637 - phosphoribosylamine-glycine ligase activity
GO:0004641 - phosphoribosylformylglycinamidine cyclo-ligase activity
GO:0004644 - phosphoribosylglycinamide formyltransferase activity
GO:0005524 - ATP binding
and 12 others

more...
Homologous interactions 7

Homologous interactions

Color coding for hit scores

1 1010
Hs

1 1010
+ Cj
+ At
+ Ss
+ Ec
+ Hs
+ Dr
+ Ec

Service provided by Combinatics, Japan

Last updated: 11Aug2025