Protein: AL1L2
Mitochondrial 10-formyltetrahydrofolate dehydrogenase (Mitochondrial 10-FTHFDH) (mtFDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L2)

Gene: AL1L2, ALDH1L2
Organism: Homo sapiens
Interactions: 55
UniProt ID: Q3SY69

Gene Ontology (top 5):
GO:0004029 - aldehyde dehydrogenase (NAD+) activity
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006635 - fatty acid beta-oxidation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

296663

AL1L1
Cytosolic 10-formyltetrahydrofolate dehydrogenase

2

14

High-throughput

0.789

High

1187810

SGT1
Protein SGT1 homolog

3

3

High-throughput

0.609

High

1162349

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

2

High-throughput

0.584

High

1123301

ICT1
Large ribosomal subunit protein mL62

1

2

High-throughput

0.536

High

1187791

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

843617

HD
Huntingtin

1

2

High-throughput

0.515

High

1187804

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

0

High-throughput

0.513

High

384429

CRYAA
Alpha-crystallin A chain

1

1

High-throughput

0.501

High

508069

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.501

High

471055

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

4

High-throughput

0.479

High

675045

TNR6
Tumor necrosis factor receptor superfamily member 6

1

1

High-throughput

0.479

High

766601

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

830844

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

1015482

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.479

High

1058049

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

High-throughput

0.479

High

1187795

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

Small-scale

0.479

High

1187797

CLUA1
Clusterin-associated protein 1

1

1

High-throughput

0.479

High

1187801

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

1187802

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

6

High-throughput

0.479

High

1187809

FZR1
Fizzy-related protein homolog

1

2

High-throughput

0.479

High

287939

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

0

High-throughput

0.458

High

299655

ATP5L
ATP synthase F(0) complex subunit g, mitochondrial

1

0

High-throughput

0.458

High

488010

DPOLA
DNA polymerase alpha catalytic subunit

1

0

High-throughput

0.458

High

1187789

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.458

High

1187792

TTC5
Tetratricopeptide repeat protein 5

1

0

High-throughput

0.458

High

1187800

INT14
Integrator complex subunit 14

1

0

High-throughput

0.458

High

1187805

ANLN
Anillin

1

0

High-throughput

0.458

High

437692

HEPS
Serine protease hepsin

1

1

High-throughput

0.445

High

528457

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

1

High-throughput

0.445

High

653350

HEMH
Ferrochelatase, mitochondrial

1

2

High-throughput

0.445

High

1187794

SFXN5
Sideroflexin-5

1

1

High-throughput

0.445

High

1187806

ITM2C
Integral membrane protein 2C

1

1

High-throughput

0.445

High

1187812

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

7

High-throughput

0.445

High

293773

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

942653

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

2

High-throughput

0.437

High

970600

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.437

High

1187788

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

1187808

UBQL2
Ubiquilin-2

1

1

High-throughput

0.437

High

593592

GDC
Solute carrier family 25 member 16

1

0

High-throughput

0.426

High

869168

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.426

High

1187799

SYMM
Methionine--tRNA ligase, mitochondrial

1

0

High-throughput

0.426

High

73812

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

4

High-throughput

0.407

High

342574

LY86
Lymphocyte antigen 86

1

1

High-throughput

0.407

High

388636

C1QA
Complement C1q subcomponent subunit A

1

4

High-throughput

0.407

High

388780

C1QC
Complement C1q subcomponent subunit C

1

4

High-throughput

0.407

High

1187787

ODFP2
Outer dense fiber protein 2

1

1

High-throughput

0.407

High

1187796

EMID1
EMI domain-containing protein 1

1

2

High-throughput

0.407

High

1187811

NPTN
Neuroplastin

1

3

High-throughput

0.407

High

1187803

WDR11
WD repeat-containing protein 11

3

0

High-throughput

0.347

High

1187790

TMM25
Transmembrane protein 25

2

0

High-throughput

0.298

High

1187807

GCP4
Gamma-tubulin complex component 4

1

0

High-throughput

0.279

Low

683726

PTX3
Pentraxin-related protein PTX3

1

0

High-throughput

0.269

Low

1187798

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.249

Low

260873

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.232

Low

1187793

S39AB
Zinc transporter ZIP11

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025