HitPredict

Interactor 1: NKG2D (P26718)
NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NKG2-D-activating NK receptor) (CD antigen CD314)
Gene: KLRK1

Interactor 2: ULBP6 (Q5VY80)
UL16-binding protein 6 (Retinoic acid early transcript 1L protein)
Gene: RAET1L

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	28559451, 19658097
Identification Methods	surface plasmon resonance, x-ray crystallography, fluorescence-activated cell sorting
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Lectin_C~MHC_I
Common GO terms	GO:0005886 - plasma membrane GO:0009897 - external side of plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 216 Hs			1 246
+	Hs
		644716 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		ULBP5_HUMAN (1-228): 3.46e-108: 317: 88.60
+	Hs
		644723 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		ULBP1_HUMAN (1-245): 7.08e-92: 272: 60.41
+	Hs
		382561 CLC4A_HUMAN (53-216): 7.85e-42: 143: 21.02		HLAA_HUMAN (24-245): 7.92e-107: 314: 19.05
+	Hs
		382559 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAA_HUMAN (24-245): 7.92e-107: 314: 19.05
+	Hs
		354602 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAB_HUMAN (24-245): 5.17e-105: 310: 19.05
+	Hs
		644721 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		ULBP3_HUMAN (1-246): 5.63e-88: 262: 53.44
+	Hs
		354302 NKG2A_HUMAN (22-215): 1.77e-40: 139: 22.56		HLAB_HUMAN (24-245): 5.17e-105: 310: 19.05
+	Hs
		644722 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		ULBP2_HUMAN (1-246): 1.14e-86: 259: 94.31
+	Hs
		570305 NKG2A_HUMAN (22-215): 1.77e-40: 139: 22.56		HLAG_HUMAN (9-245): 3.4e-104: 306: 18.95
+	Hs
		488421 CLC4A_HUMAN (53-216): 7.85e-42: 143: 21.02		HLAC_HUMAN (24-245): 1e-101: 301: 18.62
+	Hs
		488420 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAC_HUMAN (24-245): 1e-101: 301: 18.62
+	Hs
		533125 NKG2C_HUMAN (22-215): 9.17e-41: 140: 20.71		HLAE_HUMAN (24-245): 8.37e-98: 291: 21.65
+	Hs
		533124 NKG2A_HUMAN (22-215): 1.77e-40: 139: 22.56		HLAE_HUMAN (24-245): 8.37e-98: 291: 21.65
+	Hs
		644718 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		RAE1E_HUMAN (29-246): 1.17e-74: 229: 32.57
+	Mm
		139594 NKG2D_MOUSE (1-216): 7.27e-52: 168: 54.94		RAE1B_MOUSE (1-226): 2.71e-82: 248: 23.14
+	Hs
		674001 CLC4A_HUMAN (53-216): 7.85e-42: 143: 21.02		HLAF_HUMAN (24-245): 3.03e-90: 271: 18.62
+	Hs
		674000 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAF_HUMAN (24-245): 3.03e-90: 271: 18.62
+	Hs
		1278673 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HMR1_HUMAN (12-245): 1.16e-85: 259: 23.01
+	Hs
		644688 NKG2C_HUMAN (22-215): 9.17e-41: 140: 20.71		HMR1_HUMAN (12-245): 1.16e-85: 259: 23.01
+	Hs
		644616 NKG2A_HUMAN (22-215): 1.77e-40: 139: 22.56		HMR1_HUMAN (12-245): 1.16e-85: 259: 23.01