Protein: CLH
Clathrin heavy chain

Gene: CLH, CHC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 204
UniProt ID: P22137

Gene Ontology (top 5):
GO:0005198 - structural molecule activity
GO:0005829 - cytosol
GO:0006886 - intracellular protein transport
GO:0006895 - Golgi to endosome transport
GO:0006897 - endocytosis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

609204

CLC1
Clathrin light chain

13

7

Small-scale

0.981

High

644770

GGA2
ADP-ribosylation factor-binding protein GGA2

5

17

Small-scale

0.915

High

644854

AP1G1
AP-1 complex subunit gamma-1

2

9

Small-scale

0.793

High

644844

GGA1
ADP-ribosylation factor-binding protein GGA1

2

17

Small-scale

0.768

High

644738

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

5

4

Small-scale

0.723

High

644862

ENT1
Epsin-1

5

12

Small-scale

0.718

High

644841

ENT2
Epsin-2

4

12

Small-scale

0.696

High

644831

ENT5
Epsin-5

4

11

Small-scale

0.689

High

644858

INP53
Polyphosphatidylinositol phosphatase INP53

4

4

Small-scale

0.684

High

644846

SWA2
Auxilin-like clathrin uncoating factor SWA2

4

8

Small-scale

0.677

High

644750

AP1B1
AP-1 complex subunit beta-1

3

11

Small-scale

0.671

High

644861

LAS17
Proline-rich protein LAS17

3

2

Small-scale

0.662

High

644744

SLA2
Protein SLA2

3

11

Small-scale

0.658

High

644736

HSP7F
Heat shock protein homolog SSE1

3

9

High-throughput

0.657

High

523069

HSP71
Heat shock protein SSA1

3

7

High-throughput

0.650

High

644771

AP18A
Clathrin coat assembly protein AP180A

2

11

Small-scale

0.643

High

644735

PAN1
Actin cytoskeleton-regulatory complex protein PAN1

3

7

Small-scale

0.641

High

575303

EI2BA
Translation initiation factor eIF2B subunit alpha

3

0

High-throughput

0.622

High

644753

ALY1
Arrestin-related trafficking adapter 6

1

1

Small-scale

0.618

High

644805

ALY2
Arrestin-related trafficking adapter 3

1

1

Small-scale

0.618

High

644717

SIS1
Protein SIS1

2

1

High-throughput

0.614

High

644711

HSP74
Heat shock protein SSA4

2

7

High-throughput

0.611

High

644817

AP18B
Clathrin coat assembly protein AP180B

2

11

Small-scale

0.602

High

644778

END3
Actin cytoskeleton-regulatory complex protein END3

2

8

Small-scale

0.595

High

644737

HSP79
Heat shock protein homolog SSE2

2

10

High-throughput

0.588

High

644755

GBLP
Small ribosomal subunit protein RACK1

2

6

Small-scale

0.584

High

644761

ATG8
Autophagy-related protein 8

2

11

Small-scale

0.584

High

644807

ENT3
Epsin-3

2

11

Small-scale

0.584

High

644792

LYS12
Homoisocitrate dehydrogenase, mitochondrial

2

1

High-throughput

0.567

High

622870

CSK22
Casein kinase II subunit alpha'

1

4

Small-scale

0.561

High

644809

BRO1
Vacuolar-sorting protein BRO1

1

1

Small-scale

0.561

High

525931

HSP72
Heat shock protein SSA2

2

7

High-throughput

0.552

High

644794

AGE2
ADP-ribosylation factor GTPase-activating protein effector protein 2

1

4

High-throughput

0.541

High

644826

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

2

High-throughput

0.536

High

644830

GCN5
Histone acetyltransferase GCN5

1

6

High-throughput

0.536

High

644728

VPS10
Vacuolar protein sorting/targeting protein VPS10

1

0

High-throughput

0.518

High

644783

FHP
Flavohemoprotein

1

0

High-throughput

0.518

High

644814

INP52
Polyphosphatidylinositol phosphatase INP52

1

4

Small-scale

0.515

High

644724

AP2B
AP-2 complex subunit beta

1

10

Small-scale

0.501

High

644798

GTS1
Protein GTS1

1

6

Small-scale

0.501

High

449066

CALM
Calmodulin

1

1

High-throughput

0.500

High

536074

ARF1
ADP-ribosylation factor 1

1

2

High-throughput

0.500

High

587283

ABP1
Actin-binding protein

1

4

High-throughput

0.500

High

644607

MDHC
Malate dehydrogenase, cytoplasmic

1

2

High-throughput

0.500

High

644713

RFA1
Replication factor A protein 1

1

2

High-throughput

0.500

High

644733

MKK2
MAP kinase kinase MKK2/SSP33

1

7

High-throughput

0.500

High

644758

AP3M
AP-3 complex subunit mu

1

4

High-throughput

0.500

High

644791

PRK1
Actin-regulating kinase PRK1

1

6

High-throughput

0.500

High

644815

UBC13
Ubiquitin-conjugating enzyme E2 13

1

1

High-throughput

0.500

High

644818

SSK2
MAP kinase kinase kinase SSK2

1

2

High-throughput

0.500

High

644825

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

3

High-throughput

0.500

High

585585

STI1
Heat shock protein STI1

1

2

High-throughput

0.494

High

644757

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

6

High-throughput

0.489

High

638968

VPS1
Vacuolar protein sorting-associated protein 1

1

2

Small-scale

0.481

High

644765

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.479

High

149585

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

392234

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.479

High

454879

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

512259

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

578855

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.479

High

585853

CSK21
Casein kinase II subunit alpha

1

4

Small-scale

0.479

High

644715

VPS34
Phosphatidylinositol 3-kinase VPS34

1

5

High-throughput

0.479

High

644721

CDC48
Cell division control protein 48

1

2

High-throughput

0.479

High

644723

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

644727

HS104
Heat shock protein 104

1

1

High-throughput

0.479

High

644730

ARP2
Actin-related protein 2

1

1

High-throughput

0.479

High

644766

ARPC1
Actin-related protein 2/3 complex subunit 1

1

8

High-throughput

0.479

High

644785

RSP5
E3 ubiquitin-protein ligase RSP5

1

4

Small-scale

0.479

High

644803

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

7

High-throughput

0.479

High

644806

ARP3
Actin-related protein 3

1

1

High-throughput

0.479

High

644827

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

644848

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

644853

RS10A
Small ribosomal subunit protein eS10A

1

4

High-throughput

0.479

High

644800

BNI1
Protein BNI1

1

0

Small-scale

0.460

High

383520

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

409938

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

433450

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

434829

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

435776

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

441707

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

502851

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.458

High

512822

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.458

High

514459

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

644719

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

644740

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

644742

ARPC4
Actin-related protein 2/3 complex subunit 4

1

0

High-throughput

0.458

High

644745

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

644747

AP1S1
AP-1 complex subunit sigma-1

1

0

Small-scale

0.458

High

644749

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

644774

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

644782

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

644793

ARPC5
Actin-related protein 2/3 complex subunit 5

1

0

High-throughput

0.458

High

644810

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

644819

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

High-throughput

0.458

High

644851

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

644855

CHS5
Chitin biosynthesis protein CHS5

1

0

Small-scale

0.458

High

644790

VPS27
Vacuolar protein sorting-associated protein 27

1

18

Small-scale

0.457

High

644857

UBX3
UBX domain-containing protein 3

1

1

Small-scale

0.457

High

364331

CDK1
Cyclin-dependent kinase 1

1

2

High-throughput

0.457

High

459018

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

1

High-throughput

0.457

High

627829

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

1

6

High-throughput

0.457

High

644712

DBF2
Cell cycle protein kinase DBF2

1

4

High-throughput

0.457

High

644716

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

1

High-throughput

0.457

High

644729

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

3

High-throughput

0.457

High

644767

KSP1
Serine/threonine-protein kinase KSP1

1

3

High-throughput

0.457

High

644772

KOG1
Target of rapamycin complex 1 subunit KOG1

1

3

High-throughput

0.457

High

644777

TEM1
Protein TEM1

1

4

High-throughput

0.457

High

644786

PTP3
Tyrosine-protein phosphatase 3

1

1

High-throughput

0.457

High

644824

CDC14
Tyrosine-protein phosphatase CDC14

1

7

High-throughput

0.457

High

644836

UTP5
U3 small nucleolar RNA-associated protein 5

1

5

High-throughput

0.457

High

644838

KU80
ATP-dependent DNA helicase II subunit 2

1

1

High-throughput

0.457

High

644864

HSH49
Protein HSH49

1

1

High-throughput

0.457

High

543827

SSB1
Ribosome-associated molecular chaperone SSB1

1

7

High-throughput

0.445

High

644746

SPT7
SAGA complex subunit SPT7

1

3

High-throughput

0.445

High

644769

SSZ1
Ribosome-associated complex subunit SSZ1

1

6

High-throughput

0.445

High

644789

SSB2
Ribosome-associated molecular chaperone SSB2

1

7

High-throughput

0.445

High

644795

DJP1
DnaJ-like protein 1

1

1

High-throughput

0.445

High

623767

MYO2
Myosin-2

1

2

Small-scale

0.439

High

644743

SNC2
Synaptobrevin homolog 2

1

0

High-throughput

0.438

High

380968

H2B1
Histone H2B.1

1

1

High-throughput

0.437

High

381401

H2B2
Histone H2B.2

1

1

High-throughput

0.437

High

464550

PBS2
MAP kinase kinase PBS2

1

6

High-throughput

0.437

High

610091

PDI
Protein disulfide-isomerase

1

1

High-throughput

0.437

High

644714

KCC2
Calcium/calmodulin-dependent protein kinase II

1

1

High-throughput

0.437

High

644731

EUG1
Protein disulfide-isomerase EUG1

1

1

High-throughput

0.437

High

644732

HOG1
Mitogen-activated protein kinase HOG1

1

3

High-throughput

0.437

High

644751

CENPA
Histone H3-like centromeric protein CSE4

1

2

High-throughput

0.437

High

644768

ECM29
Proteasome component ECM29

1

3

High-throughput

0.437

High

644823

H3
Histone H3

1

2

High-throughput

0.437

High

644829

TOM1
E3 ubiquitin-protein ligase TOM1

1

4

High-throughput

0.437

High

644833

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.437

High

644860

DBP10
ATP-dependent RNA helicase DBP10

1

5

High-throughput

0.437

High

394240

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

644776

SNF11
Transcription regulatory protein SNF11

1

0

High-throughput

0.426

High

644813

SOL1
6-phosphogluconolactonase-like protein 1

1

0

High-throughput

0.426

High

386565

TBB
Tubulin beta chain

1

1

High-throughput

0.407

High

592014

VATB
V-type proton ATPase subunit B

1

3

High-throughput

0.407

High

644725

KCC1
Calcium/calmodulin-dependent protein kinase I

1

1

High-throughput

0.407

High

644779

XDJ1
DnaJ protein homolog XDJ1

1

1

High-throughput

0.407

High

644812

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

2

High-throughput

0.407

High

644832

WDR59
Maintenance of telomere capping protein 5

1

9

High-throughput

0.407

High

644842

ARPC3
Actin-related protein 2/3 complex subunit 3

2

0

High-throughput

0.320

High

550747

INO1
Inositol-3-phosphate synthase

1

0

High-throughput

0.282

High

644754

PAM1
Protein PAM1

1

0

High-throughput

0.279

Low

644756

PP2C4
Protein phosphatase 2C homolog 4

1

0

High-throughput

0.279

Low

644840

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

High-throughput

0.279

Low

644863

SUS1
SAGA complex subunit SUS1

1

0

High-throughput

0.279

Low

421263

PHR
Deoxyribodipyrimidine photo-lyase, mitochondrial

1

0

High-throughput

0.261

Low

576936

AMPL
Vacuolar aminopeptidase 1

1

0

High-throughput

0.261

Low

585678

UBC4
Ubiquitin-conjugating enzyme E2 4

1

0

High-throughput

0.261

Low

603006

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.261

Low

624965

PRP6
Pre-mRNA-splicing factor 6

1

0

High-throughput

0.261

Low

639539

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

0

High-throughput

0.261

Low

644718

YCP2
Uncharacterized protein YCR001W

1

0

High-throughput

0.261

Low

644720

DMC1
Meiotic recombination protein DMC1

1

0

High-throughput

0.261

Low

644722

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

High-throughput

0.261

Low

644739

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

0

High-throughput

0.261

Low

644741

SUI1
Eukaryotic translation initiation factor eIF-1

1

0

High-throughput

0.261

Low

644762

MOH1
Protein yippee-like MOH1

1

0

High-throughput

0.261

Low

644764

SHE3
SWI5-dependent HO expression protein 3

1

0

High-throughput

0.261

Low

644773

UTP9
U3 small nucleolar RNA-associated protein 9

1

0

High-throughput

0.261

Low

644784

VPS8
Vacuolar protein sorting-associated protein 8

1

0

High-throughput

0.261

Low

644802

SKP2
F-box protein SKP2

1

0

High-throughput

0.261

Low

644804

YFI6
Uncharacterized protein YFR016C

1

0

High-throughput

0.261

Low

644821

OCA2
Tyrosine-protein phosphatase-like protein OCA2

1

0

High-throughput

0.261

Low

644834

VPS64
Vacuolar protein sorting-associated protein 64

1

0

High-throughput

0.261

Low

644835

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.261

Low

644837

PEX12
Peroxisome assembly protein 12

1

0

High-throughput

0.261

Low

644839

SPC24
Kinetochore protein SPC24

1

0

High-throughput

0.261

Low

644847

PRP11
Pre-mRNA-splicing factor PRP11

1

0

High-throughput

0.261

Low

644850

DIA2
Protein DIA2

1

0

High-throughput

0.261

Low

644859

SWM1
Anaphase-promoting complex subunit SWM1

1

0

High-throughput

0.261

Low

644799

BUD6
Bud site selection protein 6

1

0

Small-scale

0.251

Low

381872

H4
Histone H4

1

0

High-throughput

0.249

Low

401887

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.249

Low

560272

KEX2
Kexin

1

0

Small-scale

0.249

Low

644726

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

644734

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.249

Low

644748

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.249

Low

644760

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

644763

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.249

Low

644780

DHH1
ATP-dependent RNA helicase DHH1

1

0

High-throughput

0.249

Low

644788

YEY6
MYG1 protein YER156C

1

0

Small-scale

0.249

Low

644796

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

644797

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.249

Low

644811

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

644816

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

644822

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

644828

ESP1
Separin

1

0

High-throughput

0.249

Low

644843

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

644845

ATG23
Autophagy-related protein 23

1

0

High-throughput

0.249

Low

644849

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

644856

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.249

Low

644865

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low

486031

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.232

Low

644752

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.232

Low

644759

SEA4
SEH-associated protein 4

1

0

High-throughput

0.232

Low

644775

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.232

Low

644781

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.232

Low

644787

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

0

High-throughput

0.232

Low

644801

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low

644808

GPC1
Glycerophosphocholine acyltransferase 1

1

0

High-throughput

0.232

Low

644820

FMP41
Oxaloacetate tautomerase FMP41, mitochondrial

1

0

High-throughput

0.232

Low

644852

AB140
tRNA(Thr)

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025