HitPredict

Interactor 1: NKG2D (P26718)
NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NKG2-D-activating NK receptor) (CD antigen CD314)
Gene: KLRK1

Interactor 2: ULBP3 (Q9BZM4)
UL16-binding protein 3 (ALCAN-gamma) (NKG2D ligand 3) (N2DL-3) (NKG2DL3) (Retinoic acid early transcript 1N)
Gene: ULBP3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.840

Property	Details
Experiments	11754823, 28559451, 18544572
Identification Methods	x-ray crystallography, surface plasmon resonance, fluorescence-activated cell sorting
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Lectin_C~MHC_I
Common GO terms	GO:0005886 - plasma membrane GO:0009897 - external side of plasma membrane GO:0030101 - natural killer cell activation GO:0042267 - natural killer cell mediated cytotoxicity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 216 Hs			1 244
+	Hs
		644723 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		ULBP1_HUMAN (1-243): 2.59e-106: 308: 54.10
+	Hs
		382561 CLC4A_HUMAN (53-216): 7.85e-42: 143: 21.02		HLAA_HUMAN (8-240): 1.83e-116: 338: 23.21
+	Hs
		382559 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAA_HUMAN (8-240): 1.83e-116: 338: 23.21
+	Hs
		644716 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		ULBP5_HUMAN (1-227): 4.07e-96: 286: 55.02
+	Hs
		354602 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAB_HUMAN (8-240): 1.81e-113: 331: 22.79
+	Hs
		644722 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		ULBP2_HUMAN (3-244): 1.32e-96: 284: 51.02
+	Hs
		570305 NKG2A_HUMAN (22-215): 1.77e-40: 139: 22.56		HLAG_HUMAN (8-241): 3.14e-114: 332: 21.43
+	Hs
		354302 NKG2A_HUMAN (22-215): 1.77e-40: 139: 22.56		HLAB_HUMAN (8-240): 1.81e-113: 331: 22.79
+	Hs
		488421 CLC4A_HUMAN (53-216): 7.85e-42: 143: 21.02		HLAC_HUMAN (7-240): 7.71e-110: 322: 21.85
+	Hs
		488420 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAC_HUMAN (7-240): 7.71e-110: 322: 21.85
+	Hs
		644714 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		ULBP6_HUMAN (22-244): 3.96e-91: 270: 51.33
+	Hs
		533125 NKG2C_HUMAN (22-215): 9.17e-41: 140: 20.71		HLAE_HUMAN (25-240): 5.91e-104: 306: 24.55
+	Hs
		533124 NKG2A_HUMAN (22-215): 1.77e-40: 139: 22.56		HLAE_HUMAN (25-240): 5.91e-104: 306: 24.55
+	Hs
		674001 CLC4A_HUMAN (53-216): 7.85e-42: 143: 21.02		HLAF_HUMAN (9-240): 1.97e-97: 289: 21.61
+	Hs
		674000 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HLAF_HUMAN (9-240): 1.97e-97: 289: 21.61
+	Hs
		1278673 CLC4E_HUMAN (25-213): 8.57e-42: 142: 19.90		HMR1_HUMAN (11-240): 2.96e-92: 276: 24.35
+	Hs
		644688 NKG2C_HUMAN (22-215): 9.17e-41: 140: 20.71		HMR1_HUMAN (11-240): 2.96e-92: 276: 24.35
+	Hs
		644616 NKG2A_HUMAN (22-215): 1.77e-40: 139: 22.56		HMR1_HUMAN (11-240): 2.96e-92: 276: 24.35
+	Hs
		644718 NKG2D_HUMAN (1-216): 1.32e-59: 188: 100.00		RAE1E_HUMAN (31-241): 1.07e-44: 152: 41.23
+	Hs
		1100221 CLC4A_HUMAN (53-216): 7.85e-42: 143: 21.02		MICB_HUMAN (30-212): 7.05e-09: 57.4: 27.13