HitPredict

Interactor 1: AVR2A (P27037)
Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA)
Gene: ACVR2A

Interactor 2: HAVR2 (Q8TDQ0)
Hepatitis A virus cellular receptor 2 (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3) (CD antigen CD366)
Gene: HAVCR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Activin_recp~V-set, Pkinase~V-set
Common GO terms	GO:0009986 - cell surface GO:0046872 - metal ion binding
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 513 Hs			1 301
+	Hs
		738384 BMR1A_HUMAN (59-488): 2.92e-128: 385: 33.41		HAVR2_HUMAN (1-301): 0: 542: 100.00
+	Hs
		738567 TGFR1_HUMAN (60-488): 5.17e-120: 363: 32.31		HAVR1_HUMAN (10-133): 2.47e-51: 174: 40.95
+	Hs
		738478 ACV1B_HUMAN (2-488): 1.4e-113: 346: 28.41		HAVR1_HUMAN (10-133): 2.47e-51: 174: 40.95