Protein: FKS1
1,3-beta-glucan synthase component FKS1 (EC 2.4.1.34) (1,3-beta-D-glucan-UDP glucosyltransferase) (Calcineurin dependent protein 1) (Calcofluor white hypersensitivity protein 53) (Echinocandin target gene protein 1) (FK506 sensitivity protein 1) (Glucan synthase of cerevisiae protein 1) (Papulacandin B resistance protein 1)

Gene: FKS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 177
UniProt ID: P38631

Gene Ontology (top 5):
GO:0000148 - 1,3-beta-D-glucan synthase complex
GO:0003843 - 1,3-beta-D-glucan synthase activity
GO:0005739 - mitochondrion
GO:0005886 - plasma membrane
GO:0005933 - cellular bud

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

448529

RHO1
GTP-binding protein RHO1

3

0

Small-scale

0.649

High

801063

FKS2
1,3-beta-glucan synthase component GSC2

1

1

High-throughput

0.618

High

801047

FLC2
Flavin carrier protein 2

2

2

High-throughput

0.588

High

801068

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.584

High

726988

HS104
Heat shock protein 104

3

1

High-throughput

0.578

High

797830

FTH1
Iron transporter FTH1

2

0

High-throughput

0.563

High

801054

SCS2
Vesicle-associated membrane protein-associated protein SCS2

2

0

High-throughput

0.563

High

523809

HSP71
Heat shock protein SSA1

2

4

High-throughput

0.552

High

747187

PMP1
Plasma membrane ATPase proteolipid 1

2

0

High-throughput

0.547

High

796908

PHO88
SRP-independent targeting protein 3

2

0

High-throughput

0.547

High

564727

ATC1
Calcium-transporting ATPase 1

1

1

High-throughput

0.536

High

668427

PTP1
Tyrosine-protein phosphatase 1

1

1

High-throughput

0.536

High

801049

RSP5
E3 ubiquitin-protein ligase RSP5

1

2

High-throughput

0.536

High

801058

PRK1
Actin-regulating kinase PRK1

1

1

High-throughput

0.536

High

801075

CLA4
Serine/threonine-protein kinase CLA4

1

1

High-throughput

0.536

High

801092

ARK1
Actin-regulating kinase 1

1

1

High-throughput

0.536

High

801061

DSN1
Kinetochore-associated protein DSN1

2

1

High-throughput

0.533

High

618866

GAP1
General amino-acid permease GAP1

1

0

Small-scale

0.529

High

747333

RSSA1
Small ribosomal subunit protein uS2A

2

1

High-throughput

0.521

High

800893

NCB5R
NADH-cytochrome b5 reductase 1

1

1

High-throughput

0.515

High

560687

KIN2
Serine/threonine-protein kinase KIN2

1

0

High-throughput

0.513

High

599353

FUS3
Mitogen-activated protein kinase FUS3

1

0

High-throughput

0.513

High

801050

BEM2
GTPase-activating protein BEM2/IPL2

1

0

High-throughput

0.513

High

801078

PHB2
Prohibitin-2

1

0

High-throughput

0.513

High

574576

YAK1
Dual specificity protein kinase YAK1

1

1

High-throughput

0.489

High

646031

KIN3
Serine/threonine-protein kinase KIN3

1

3

High-throughput

0.489

High

792395

BOI1
BEM1-interacting protein 1

1

1

Small-scale

0.481

High

801051

BOI2
BEM1-interacting protein 2

1

1

Small-scale

0.481

High

801130

AIM44
Altered inheritance of mitochondria protein 44

1

0

Small-scale

0.479

High

382896

RMAR
Small ribosomal subunit protein uS3m

1

1

High-throughput

0.479

High

454731

KAPR
cAMP-dependent protein kinase regulatory subunit

1

1

Small-scale

0.479

High

556568

STE6
Alpha-factor-transporting ATPase

1

1

High-throughput

0.479

High

712784

CHS3
Chitin synthase 3

1

2

High-throughput

0.479

High

724264

SNC1
Synaptobrevin homolog 1

1

2

High-throughput

0.479

High

744380

ATC5
Phospholipid-transporting ATPase DNF1

1

1

High-throughput

0.479

High

746428

SSO1
Protein SSO1

1

1

High-throughput

0.479

High

751576

SNC2
Synaptobrevin homolog 2

1

2

High-throughput

0.479

High

801066

LEM3
Phospholipid-transporting ATPase accessory subunit LEM3

1

2

High-throughput

0.479

High

801102

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

801104

YM8V
Uncharacterized protein YMR295C

1

1

High-throughput

0.479

High

801116

SSP2
Sporulation-specific protein 2

1

1

Small-scale

0.479

High

801119

FLC1
Flavin carrier protein 1

1

2

High-throughput

0.479

High

801127

ATC4
Phospholipid-transporting ATPase DNF2

1

1

High-throughput

0.479

High

711495

BEM1
Bud emergence protein 1

1

0

Small-scale

0.460

High

464590

PBS2
MAP kinase kinase PBS2

1

0

High-throughput

0.458

High

646663

VPS15
Serine/threonine-protein kinase VPS15

1

0

High-throughput

0.458

High

647095

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

678099

SYP1
Suppressor of yeast profilin deletion

1

0

Small-scale

0.458

High

679632

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

691608

AP2B
AP-2 complex subunit beta

1

0

Small-scale

0.458

High

709370

HRR25
Casein kinase I homolog HRR25

1

0

Small-scale

0.458

High

801045

PHO90
Low-affinity phosphate transporter PHO90

1

0

High-throughput

0.458

High

801048

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.458

High

801065

MMM1
Maintenance of mitochondrial morphology protein 1

1

0

Small-scale

0.458

High

801067

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

801070

ATG27
Autophagy-related protein 27

1

0

High-throughput

0.458

High

801081

MDM34
Mitochondrial distribution and morphology protein 34

1

0

Small-scale

0.458

High

801083

AIM14
Probable metalloreductase AIM14

1

0

High-throughput

0.458

High

801086

TNA1
High-affinity nicotinic acid transporter

1

0

High-throughput

0.458

High

801090

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

801091

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.458

High

801100

ESP1
Separin

1

0

High-throughput

0.458

High

801105

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.458

High

801107

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.458

High

801108

SEC13
Protein transport protein SEC13

1

0

High-throughput

0.458

High

801121

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.458

High

392663

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.445

High

526580

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.445

High

571032

CHS2
Chitin synthase 2

1

2

High-throughput

0.445

High

740258

SMI1
Cell wall assembly regulator SMI1

1

1

High-throughput

0.445

High

801043

YM11
Uncharacterized protein YMR124W

1

1

High-throughput

0.445

High

801098

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

1

High-throughput

0.445

High

801079

SCS3
Acyl-coenzyme A diphosphatase SCS3

1

1

Small-scale

0.439

High

582454

SEC23
Protein transport protein SEC23

1

1

High-throughput

0.437

High

705171

PEX3
Peroxisomal biogenesis factor 3

1

1

High-throughput

0.437

High

706982

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

779219

CENPA
Histone H3-like centromeric protein CSE4

1

3

High-throughput

0.437

High

801039

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

801044

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

801057

SEC24
Protein transport protein SEC24

1

1

High-throughput

0.437

High

801071

MPS3
Spindle pole body assembly component MPS3

1

1

High-throughput

0.437

High

801077

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

801087

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.437

High

801095

H3
Histone H3

1

3

High-throughput

0.437

High

801103

VPS60
Vacuolar protein-sorting-associated protein 60

1

1

Small-scale

0.437

High

801125

CMR1
DNA damage-binding protein CMR1

1

1

High-throughput

0.437

High

735825

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.426

High

745234

COX13
Cytochrome c oxidase subunit 13, mitochondrial

1

0

High-throughput

0.426

High

746029

YME2
Mitochondrial escape protein 2

1

0

High-throughput

0.426

High

780098

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.426

High

801053

PIC2
Mitochondrial phosphate carrier protein 2

1

0

High-throughput

0.426

High

801055

COX15
Heme A synthase COX15

1

0

High-throughput

0.426

High

801060

SNL1
HSP70 co-chaperone SNL1

1

0

High-throughput

0.426

High

801080

ERG25
C-4 methylsterol oxidase ERG25

1

0

High-throughput

0.426

High

801084

YG1I
Uncharacterized membrane protein YGR026W

1

0

High-throughput

0.426

High

801113

CRLS1
Cardiolipin synthase

1

0

High-throughput

0.426

High

801120

FSF1
Sideroflexin FSF1

1

0

High-throughput

0.426

High

801122

NCE2
Non-classical export protein 2

1

0

High-throughput

0.426

High

801129

YB111
Uncharacterized helicase-like protein YBL111C

1

0

High-throughput

0.426

High

792786

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.417

High

509527

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

1

High-throughput

0.407

High

801089

PFD4
Prefoldin subunit 4

1

1

High-throughput

0.407

High

801046

ERP2
Protein ERP2

3

0

High-throughput

0.339

High

782237

BET3
Trafficking protein particle complex subunit BET3

2

0

High-throughput

0.328

High

536016

SEC7
ADP-ribosylation factor guanine nucleotide-exchange factor SEC7

2

0

High-throughput

0.324

High

641367

SEC62
Translocation protein SEC62

2

0

High-throughput

0.324

High

798373

TRS20
Trafficking protein particle complex subunit 20

2

0

High-throughput

0.324

High

801101

ERO1
Endoplasmic oxidoreductin-1

2

0

High-throughput

0.324

High

613799

SPO7
Sporulation-specific protein SPO7

2

0

High-throughput

0.307

High

801062

LCB2
Serine palmitoyltransferase 2

2

0

High-throughput

0.307

High

558697

CAF20
Cap-associated protein CAF20

2

0

High-throughput

0.305

High

737843

HOG1
Mitogen-activated protein kinase HOG1

2

0

High-throughput

0.305

High

484290

KEX1
Pheromone-processing carboxypeptidase KEX1

2

0

High-throughput

0.298

High

642378

MCK1
Protein kinase MCK1

1

0

High-throughput

0.279

Low

744043

ANP1
Mannan polymerase II complex ANP1 subunit

1

0

High-throughput

0.279

Low

801073

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

0

High-throughput

0.279

Low

801109

ERV41
ER-derived vesicles protein ERV41

1

0

High-throughput

0.279

Low

801069

SPC1
Signal peptidase complex subunit 1

1

0

High-throughput

0.269

Low

149732

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.249

Low

410101

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

433613

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

435934

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

503015

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

504185

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

512412

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

649824

VPS34
Phosphatidylinositol 3-kinase VPS34

1

0

High-throughput

0.249

Low

661509

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.249

Low

670654

SIS1
Protein SIS1

1

0

High-throughput

0.249

Low

678518

TAH1
TPR repeat-containing protein associated with Hsp90

1

0

Small-scale

0.249

Low

689425

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

738838

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.249

Low

746237

PTM1
Membrane protein PTM1

1

0

High-throughput

0.249

Low

778298

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

780013

EAP1
Protein EAP1

1

0

High-throughput

0.249

Low

780742

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.249

Low

790313

VPP2
V-type proton ATPase subunit a, Golgi isoform

1

0

High-throughput

0.249

Low

792017

GBLP
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.249

Low

795320

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.249

Low

797170

ATG14
Autophagy-related protein 14

1

0

High-throughput

0.249

Low

797732

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.249

Low

801040

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.249

Low

801041

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

801076

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

801082

ATG1
Serine/threonine-protein kinase ATG1

1

0

High-throughput

0.249

Low

801085

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

801088

ATG2
Autophagy-related protein 2

1

0

High-throughput

0.249

Low

801097

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

801099

BECN1
Vacuolar protein sorting-associated protein 30

1

0

High-throughput

0.249

Low

801106

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.249

Low

801110

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.249

Low

801111

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.249

Low

801112

ATG23
Autophagy-related protein 23

1

0

High-throughput

0.249

Low

801114

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

801115

MCA1
Metacaspase-1

1

0

High-throughput

0.249

Low

801117

ESA1
Histone acetyltransferase ESA1

1

0

Small-scale

0.249

Low

801118

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

801123

SIZ2
E3 SUMO-protein ligase SIZ2

1

0

High-throughput

0.249

Low

801126

ATG11
Autophagy-related protein 11

1

0

High-throughput

0.249

Low

801131

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low

604541

PHO81
Phosphate system positive regulatory protein PHO81

1

0

High-throughput

0.232

Low

646289

SLY41
Uncharacterized transporter SLY41

1

0

High-throughput

0.232

Low

705126

SEC20
Protein transport protein SEC20

1

0

High-throughput

0.232

Low

776354

YET1
Endoplasmic reticulum transmembrane protein 1

1

0

High-throughput

0.232

Low

780876

STB6
Protein STB6

1

0

High-throughput

0.232

Low

797378

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

0

High-throughput

0.232

Low

801042

AKR1
Palmitoyltransferase AKR1

1

0

High-throughput

0.232

Low

801052

NUG1
Nuclear GTP-binding protein NUG1

1

0

High-throughput

0.232

Low

801056

ELO3
Fatty acid elongase 3

1

0

High-throughput

0.232

Low

801059

ICE2
Protein ICE2

1

0

High-throughput

0.232

Low

801064

SYS1
Protein SYS1

1

0

High-throughput

0.232

Low

801072

NOP9
Nucleolar protein 9

1

0

High-throughput

0.232

Low

801074

SEC16
COPII coat assembly protein SEC16

1

0

High-throughput

0.232

Low

801093

TMEDA
Endoplasmic reticulum vesicle protein 25

1

0

High-throughput

0.232

Low

801094

SNA2
Protein SNA2

1

0

High-throughput

0.232

Low

801096

PEX13
Peroxisomal membrane protein PEX13

1

0

High-throughput

0.232

Low

801124

MAM3
Protein MAM3

1

0

High-throughput

0.232

Low

801128

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025