HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: GRP3 (Q8IV61)
Ras guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1)
Gene: RASGRP3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	17353931
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~C1_1
Common GO terms	GO:0007264 - small GTPase-mediated signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 690
+	Hs
		171544 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		RGL2_HUMAN (3-461): 1.1e-103: 335: 19.50
+	Hs
		171537 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		RGL2_HUMAN (3-461): 1.1e-103: 335: 19.50
+	Mm
		926773 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		RGRF2_MOUSE (69-386): 4.19e-98: 329: 25.15
+	Hs
		171538 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		RGL2_HUMAN (3-461): 1.1e-103: 335: 19.50
+	Hs
		683335 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		RGRF1_HUMAN (24-386): 3.78e-98: 330: 23.45
+	Hs
		909770 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		RGPS2_HUMAN (111-476): 1.02e-86: 285: 22.84
+	Hs
		647073 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		RGPS2_HUMAN (111-476): 1.02e-86: 285: 22.84
+	Hs
		927257 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		RGPS2_HUMAN (111-476): 1.02e-86: 285: 22.84
+	Hs
		683515 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		RGPS2_HUMAN (111-476): 1.02e-86: 285: 22.84
+	Hs
		171546 1433F_HUMAN (2-242): 7.16e-106: 307: 71.43		RGL2_HUMAN (3-461): 1.1e-103: 335: 19.50
+	Hs
		171542 1433G_HUMAN (1-242): 5.48e-105: 305: 70.33		RGL2_HUMAN (3-461): 1.1e-103: 335: 19.50
+	Hs
		684179 1433S_HUMAN (1-236): 9.86e-108: 312: 71.85		RGPS2_HUMAN (111-476): 1.02e-86: 285: 22.84
+	Hs
		982233 1433F_HUMAN (2-242): 7.16e-106: 307: 71.43		RGPS2_HUMAN (111-476): 1.02e-86: 285: 22.84
+	Hs
		904810 1433G_HUMAN (1-242): 5.48e-105: 305: 70.33		RGPS2_HUMAN (111-476): 1.02e-86: 285: 22.84
+	Hs
		910200 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		RPGF2_HUMAN (10-218): 1.47e-18: 92.7: 14.47
+	Mm
		926845 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		RPGF2_MOUSE (10-218): 9.7e-19: 93.4: 14.47
+	Hs
		647416 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		RPGF2_HUMAN (10-218): 1.47e-18: 92.7: 14.47
+	Hs
		927702 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		RPGF2_HUMAN (10-218): 1.47e-18: 92.7: 14.47
+	Hs
		683851 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		RPGF2_HUMAN (10-218): 1.47e-18: 92.7: 14.47
+	Hs
		982658 1433F_HUMAN (2-242): 7.16e-106: 307: 71.43		RPGF2_HUMAN (10-218): 1.47e-18: 92.7: 14.47