Protein: MAOM
NAD-dependent malic enzyme, mitochondrial (NAD-ME) (EC 1.1.1.38)

Gene: MAOM, MAE1
Organism: Saccharomyces cerevisiae S288C
Interactions: 126
UniProt ID: P36013

Gene Ontology (top 5):
GO:0004470 - malic enzyme activity
GO:0004471 - malate dehydrogenase (decarboxylating) (NAD+) activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006090 - pyruvate metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

510379

HSP77
Import motor subunit, mitochondrial

2

3

High-throughput

0.584

High

779458

RUVB2
RuvB-like protein 2

2

1

High-throughput

0.558

High

416109

SYTC
Threonine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.536

High

450568

FAS1
Fatty acid synthase subunit beta

1

1

High-throughput

0.536

High

470507

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.536

High

486127

TBA1
Tubulin alpha-1 chain

1

1

High-throughput

0.536

High

486447

TBA3
Tubulin alpha-3 chain

1

1

High-throughput

0.536

High

755074

GCN1
eIF-2-alpha kinase activator GCN1

1

1

High-throughput

0.536

High

779417

SMK1
Sporulation-specific mitogen-activated protein kinase SMK1

1

1

High-throughput

0.536

High

779430

BRE5
UBP3-associated protein BRE5

1

1

High-throughput

0.536

High

779434

ACAC
Acetyl-CoA carboxylase

1

2

High-throughput

0.536

High

779435

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

2

High-throughput

0.536

High

779452

MDN1
Midasin

1

1

High-throughput

0.536

High

368157

THDH
Threonine dehydratase, mitochondrial

1

0

High-throughput

0.513

High

386667

TBB
Tubulin beta chain

1

0

High-throughput

0.513

High

394441

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.513

High

453540

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.513

High

471396

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

0

High-throughput

0.513

High

531302

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.513

High

633456

PP11
Serine/threonine-protein phosphatase PP1-1

1

0

High-throughput

0.513

High

779414

PSA4
Proteasome subunit alpha type-4

1

0

High-throughput

0.513

High

365015

KPYK1
Pyruvate kinase 1

1

1

High-throughput

0.489

High

603450

VATA
V-type proton ATPase catalytic subunit A

1

3

High-throughput

0.489

High

721836

XPO1
Exportin-1

1

2

High-throughput

0.489

High

734070

EF2
Elongation factor 2

1

1

High-throughput

0.489

High

734655

IMB3
Importin subunit beta-3

1

2

High-throughput

0.489

High

740141

RPN2
26S proteasome regulatory subunit RPN2

1

1

High-throughput

0.489

High

779403

ECM29
Proteasome component ECM29

1

2

High-throughput

0.489

High

779404

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.489

High

779407

TCPD
T-complex protein 1 subunit delta

1

1

High-throughput

0.489

High

779427

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

2

High-throughput

0.489

High

779428

MSN5
Protein MSN5

1

2

High-throughput

0.489

High

779441

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

High-throughput

0.489

High

647081

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.479

High

679561

CDC48
Cell division control protein 48

1

3

High-throughput

0.479

High

752110

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.479

High

779416

FIS1
Mitochondrial fission 1 protein

1

1

Small-scale

0.479

High

779429

HST2
NAD-dependent protein deacetylase HST2

1

2

High-throughput

0.479

High

779432

ORC1
Origin recognition complex subunit 1

1

2

High-throughput

0.479

High

456385

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

0

High-throughput

0.458

High

514568

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

579184

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.458

High

654597

AIM17
Probable oxidoreductase AIM17

1

0

High-throughput

0.458

High

694468

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

0

High-throughput

0.458

High

736232

RM41
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.458

High

739337

ZUO1
Zuotin

1

0

Small-scale

0.458

High

746790

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.458

High

779399

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

779415

MLP2
Protein MLP2

1

0

High-throughput

0.458

High

779421

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

0

High-throughput

0.458

High

779440

ESP1
Separin

1

0

High-throughput

0.458

High

779453

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.458

High

779454

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

779426

PHB2
Prohibitin-2

1

1

High-throughput

0.445

High

381064

H2B1
Histone H2B.1

1

1

High-throughput

0.437

High

381486

H2B2
Histone H2B.2

1

1

High-throughput

0.437

High

502971

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

726927

HS104
Heat shock protein 104

1

1

High-throughput

0.437

High

745700

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.437

High

779445

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.437

High

359198

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

0

High-throughput

0.426

High

534249

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

0

High-throughput

0.426

High

779409

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.426

High

779423

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.426

High

592170

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.407

High

779412

IMB4
Importin subunit beta-4

1

2

High-throughput

0.407

High

779413

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.407

High

779439

NOG1
Nucleolar GTP-binding protein 1

1

1

High-throughput

0.407

High

779460

RS22B
Small ribosomal subunit protein uS8B

1

1

High-throughput

0.407

High

382026

H4
Histone H4

2

0

High-throughput

0.318

High

735706

VA0D
V-type proton ATPase subunit d

2

0

High-throughput

0.293

High

481876

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.279

Low

569754

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.279

Low

575432

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.279

Low

701687

URA7
CTP synthase 1

1

0

High-throughput

0.279

Low

747286

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.279

Low

779401

KPR3
Ribose-phosphate pyrophosphokinase 3

1

0

High-throughput

0.279

Low

779402

DBP8
ATP-dependent RNA helicase DBP8

1

0

High-throughput

0.279

Low

779405

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.279

Low

779408

TCPZ
T-complex protein 1 subunit zeta

1

0

High-throughput

0.279

Low

779411

GEA2
ARF guanine-nucleotide exchange factor 2

1

0

High-throughput

0.279

Low

779418

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.279

Low

779419

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.279

Low

779420

GCN20
Protein GCN20

1

0

High-throughput

0.279

Low

779422

SA155
SIT4-associating protein SAP155

1

0

High-throughput

0.279

Low

779437

ADA2
SAGA complex subunit ADA2

1

0

High-throughput

0.279

Low

779442

GCN5
Histone acetyltransferase GCN5

1

0

High-throughput

0.279

Low

779443

CLU
Clustered mitochondria protein 1

1

0

High-throughput

0.279

Low

779447

RPN9
26S proteasome regulatory subunit RPN9

1

0

High-throughput

0.279

Low

779450

LKHA4
Leucine aminopeptidase 2

1

0

High-throughput

0.269

Low

383627

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

434995

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.249

Low

454985

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

512932

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

513480

RL1A
Large ribosomal subunit protein uL1A

1

0

High-throughput

0.249

Low

558675

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

670567

SIS1
Protein SIS1

1

0

High-throughput

0.249

Low

676628

SGF29
SAGA complex subunit SGF29

1

0

Small-scale

0.249

Low

706758

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

734930

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

748335

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

779410

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

779424

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

779425

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

779433

H3
Histone H3

1

0

High-throughput

0.249

Low

779436

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

779438

ULP1
Ubiquitin-like-specific protease 1

1

0

High-throughput

0.249

Low

779444

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.249

Low

779446

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

779448

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

779451

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.249

Low

779455

SIZ2
E3 SUMO-protein ligase SIZ2

1

0

High-throughput

0.249

Low

779457

LAS17
Proline-rich protein LAS17

1

0

Small-scale

0.249

Low

779459

CMR1
DNA damage-binding protein CMR1

1

0

High-throughput

0.249

Low

409712

RL24A
Large ribosomal subunit protein eL24A

1

0

High-throughput

0.232

Low

438417

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

High-throughput

0.232

Low

553977

TCPA
T-complex protein 1 subunit alpha

1

0

High-throughput

0.232

Low

597728

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.232

Low

655432

RS3A2
Small ribosomal subunit protein eS1B

1

0

High-throughput

0.232

Low

688861

RS5
Small ribosomal subunit protein uS7

1

0

High-throughput

0.232

Low

738296

RPN12
26S proteasome regulatory subunit RPN12

1

0

High-throughput

0.232

Low

779400

GBLP
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.232

Low

779406

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.232

Low

779431

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low

779449

BRX1
Ribosome biogenesis protein BRX1

1

0

High-throughput

0.232

Low

779456

ARP7
Actin-related protein 7

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025