HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: ZO2 (Q9UDY2)
Tight junction protein ZO-2 (Tight junction protein 2) (Zona occludens protein 2) (Zonula occludens protein 2)
Gene: TJP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	17353931
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0019904 - protein domain specific binding GO:0044325 - transmembrane transporter binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 1190
+	Hs
		910124 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		927623 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		683788 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		684376 1433S_HUMAN (1-236): 9.86e-108: 312: 71.85		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Mm
		935715 1433F_MOUSE (2-242): 4.62e-106: 308: 71.43		ZO2_MOUSE (24-1190): 0: 785: 83.25
+	Hs
		646827 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80
+	Hs
		926961 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80
+	Hs
		683290 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80
+	Hs
		683987 1433S_HUMAN (1-236): 9.86e-108: 312: 71.85		ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80
+	Hs
		981947 1433F_HUMAN (2-242): 7.16e-106: 307: 71.43		ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80
+	Hs
		159186 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		CSKP_HUMAN (229-890): 6.3e-93: 321: 15.09
+	Mm
		910260 1433E_MOUSE (2-243): 1.31e-144: 406: 63.53		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Mm
		926805 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Mm
		1143489 1433B_MOUSE (1-242): 2.84e-124: 354: 80.99		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Dm
		677686 1433E_DROME (2-242): 6.77e-143: 401: 65.02		DLG1_DROME (12-421): 3.86e-35: 147: 17.36
+	Dm
		664599 1433Z_DROME (1-245): 3.68e-141: 397: 77.14		DLG1_DROME (12-421): 3.86e-35: 147: 17.36
+	Hs
		909845 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		DLG5_HUMAN (25-522): 2.43e-14: 80.4: 11.77
+	Hs
		647130 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		DLG5_HUMAN (25-522): 2.43e-14: 80.4: 11.77
+	Hs
		927332 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		DLG5_HUMAN (25-522): 2.43e-14: 80.4: 11.77
+	Hs
		683563 1433B_HUMAN (1-242): 5.01e-139: 391: 81.82		DLG5_HUMAN (25-522): 2.43e-14: 80.4: 11.77