Protein: GALNS
N-acetylgalactosamine-6-sulfatase (EC 3.1.6.4) (Chondroitinsulfatase) (Chondroitinase) (Galactose-6-sulfate sulfatase) (GalN6S) (N-acetylgalactosamine-6-sulfate sulfatase) (GalNAc6S sulfatase)

Gene: GALNS
Organism: Homo sapiens
Interactions: 97
UniProt ID: P34059

Gene Ontology (top 5):
GO:0003943 - N-acetylgalactosamine-4-sulfatase activity
GO:0004065 - arylsulfatase activity
GO:0005576 - extracellular region
GO:0008484 - sulfuric ester hydrolase activity
GO:0035578 - azurophil granule lumen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

582312

ARSA
Arylsulfatase A

3

7

High-throughput

0.861

High

647332

IDS
Iduronate 2-sulfatase

3

7

High-throughput

0.861

High

154799

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

3

3

High-throughput

0.667

High

756543

NAAA
N-acylethanolamine-hydrolyzing acid amidase

3

6

High-throughput

0.667

High

756544

UPAR
Urokinase plasminogen activator surface receptor

3

4

High-throughput

0.667

High

756575

DNS2B
Deoxyribonuclease-2-beta

3

1

High-throughput

0.667

High

756584

DPEP2
Dipeptidase 2

3

2

High-throughput

0.667

High

756595

PRG3
Proteoglycan 3

3

5

High-throughput

0.662

High

531982

PPBN
Alkaline phosphatase, germ cell type

2

2

High-throughput

0.628

High

567805

PRG2
Bone marrow proteoglycan

2

6

High-throughput

0.628

High

756559

LYZL1
Lysozyme-like protein 1

2

5

High-throughput

0.628

High

756562

LYZL2
Lysozyme-like protein 2

2

5

High-throughput

0.628

High

756549

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

3

4

High-throughput

0.609

High

756550

TAZ
Tafazzin

3

2

High-throughput

0.609

High

756558

LYPD4
Ly6/PLAUR domain-containing protein 4

2

0

High-throughput

0.602

High

170678

CLGN
Calmegin

2

9

High-throughput

0.549

High

322584

FBX21
F-box only protein 21

2

6

High-throughput

0.549

High

756569

WDTC1
WD and tetratricopeptide repeats protein 1

2

2

High-throughput

0.549

High

756570

SUMF1
Formylglycine-generating enzyme

2

13

High-throughput

0.549

High

756583

KLK15
Kallikrein-15

2

9

High-throughput

0.549

High

224469

PI15
Peptidase inhibitor 15

1

3

High-throughput

0.536

High

289308

FCN3
Ficolin-3

1

5

High-throughput

0.536

High

342516

LY86
Lymphocyte antigen 86

1

2

High-throughput

0.536

High

350689

NOE2
Noelin-2

1

1

High-throughput

0.536

High

416597

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

2

High-throughput

0.536

High

506828

CFC1
Cryptic protein

1

1

High-throughput

0.536

High

518814

CCL3
C-C motif chemokine 3

1

5

High-throughput

0.536

High

532399

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.536

High

534702

BIP
Endoplasmic reticulum chaperone BiP

1

7

High-throughput

0.536

High

548428

MPRI
Cation-independent mannose-6-phosphate receptor

1

7

High-throughput

0.536

High

561345

TDGF1
Protein Cripto

1

1

High-throughput

0.536

High

573352

ENPL
Endoplasmin

1

6

High-throughput

0.536

High

663538

CMA1
Chymase

1

9

High-throughput

0.536

High

731821

CEAM8
Cell adhesion molecule CEACAM8

1

4

High-throughput

0.536

High

756539

MFAP4
Microfibril-associated glycoprotein 4

1

5

High-throughput

0.536

High

756540

DEF1
Neutrophil defensin 1

1

4

High-throughput

0.536

High

756545

BST1
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2

1

1

High-throughput

0.536

High

756546

SLAF1
Signaling lymphocytic activation molecule

1

5

High-throughput

0.536

High

756555

FSTL4
Follistatin-related protein 4

1

2

High-throughput

0.536

High

756566

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

3

High-throughput

0.536

High

756576

GGH
Gamma-glutamyl hydrolase

1

3

High-throughput

0.536

High

756579

ESPB1
Epididymal sperm-binding protein 1

1

7

High-throughput

0.536

High

756580

LCFC1
Sperm-egg fusion protein LLCFC1

1

4

High-throughput

0.536

High

756586

SIAE
Sialate O-acetylesterase

1

3

High-throughput

0.536

High

756589

CBLN4
Cerebellin-4

1

4

High-throughput

0.536

High

756590

WNT16
Protein Wnt-16

1

2

High-throughput

0.536

High

756592

PSG8
Pregnancy-specific beta-1-glycoprotein 8

1

4

High-throughput

0.536

High

756596

INSL5
Insulin-like peptide INSL5

1

4

High-throughput

0.536

High

284385

CLN5
Bis(monoacylglycero)phosphate synthase CLN5

1

0

High-throughput

0.513

High

471538

CD14
Monocyte differentiation antigen CD14

1

0

High-throughput

0.513

High

756572

SACA4
Sperm acrosome membrane-associated protein 4

1

0

High-throughput

0.513

High

168383

NCTR3
Natural cytotoxicity triggering receptor 3

1

2

High-throughput

0.489

High

321187

ERLN2
Erlin-2

1

1

High-throughput

0.489

High

426055

PPB1
Alkaline phosphatase, placental type

1

2

High-throughput

0.489

High

593290

PGFRA
Platelet-derived growth factor receptor alpha

1

6

High-throughput

0.489

High

628910

TRYB2
Tryptase beta-2

1

6

High-throughput

0.489

High

634746

GRAH
Granzyme H

1

10

High-throughput

0.489

High

756542

IL5RA
Interleukin-5 receptor subunit alpha

1

4

High-throughput

0.489

High

756547

SG2A2
Mammaglobin-A

1

6

High-throughput

0.489

High

756548

MESD
LRP chaperone MESD

1

5

High-throughput

0.489

High

756553

DCAF6
DDB1- and CUL4-associated factor 6

1

2

High-throughput

0.489

High

756557

BRID5
BRICHOS domain-containing protein 5

1

1

High-throughput

0.489

High

756560

CREL2
Protein disulfide isomerase CRELD2

1

5

High-throughput

0.489

High

756563

PODN
Podocan

1

1

High-throughput

0.489

High

756565

DYR2
Dihydrofolate reductase 2, mitochondrial

1

1

High-throughput

0.489

High

756587

SDF2L
Stromal cell-derived factor 2-like protein 1

1

2

High-throughput

0.489

High

756593

AMOL2
Angiomotin-like protein 2

1

2

High-throughput

0.489

High

756594

PDIP2
Polymerase delta-interacting protein 2

1

7

High-throughput

0.489

High

756538

MTR1A
Melatonin receptor type 1A

1

2

High-throughput

0.464

High

222250

PSCA
Prostate stem cell antigen

1

3

High-throughput

0.445

High

388770

C1QC
Complement C1q subcomponent subunit C

1

4

High-throughput

0.445

High

702386

CYTD
Cystatin-D

1

4

High-throughput

0.445

High

714724

KAIN
Kallistatin

1

3

High-throughput

0.445

High

756541

LCN6
Epididymal-specific lipocalin-6

1

3

High-throughput

0.445

High

756554

NHLC3
NHL repeat-containing protein 3

1

1

High-throughput

0.445

High

756573

CA054
Uncharacterized protein C1orf54

1

6

High-throughput

0.445

High

217888

TGON2
Trans-Golgi network integral membrane protein 2

1

6

High-throughput

0.437

High

756564

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

1

Small-scale

0.437

High

756567

TM192
Transmembrane protein 192

1

1

High-throughput

0.437

High

756568

LYPD1
Ly6/PLAUR domain-containing protein 1

1

0

High-throughput

0.426

High

756574

PATE1
Prostate and testis expressed protein 1

1

0

High-throughput

0.426

High

756581

NEUR1
Sialidase-1

1

0

Small-scale

0.426

High

2094

TVA20
T cell receptor alpha variable 20

1

2

High-throughput

0.407

High

566575

PDIA4
Protein disulfide-isomerase A4

1

3

High-throughput

0.407

High

756537

FUS
RNA-binding protein FUS

1

2

High-throughput

0.407

High

756551

DB109
Beta-defensin 109B

1

2

High-throughput

0.407

High

756556

OGFD3
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3

1

1

High-throughput

0.407

High

756561

NFXL1
NF-X1-type zinc finger protein NFXL1

1

8

High-throughput

0.407

High

756591

FBX3
F-box only protein 3

1

7

High-throughput

0.407

High

756577

P2RX5
P2X purinoceptor 5

1

0

High-throughput

0.279

Low

756582

SPI2B
Spindlin-2B

1

0

High-throughput

0.279

Low

756588

DPOE4
DNA polymerase epsilon subunit 4

1

0

High-throughput

0.279

Low

593574

GDC
Solute carrier family 25 member 16

1

0

High-throughput

0.232

Low

756552

TB10B
TBC1 domain family member 10B

1

0

High-throughput

0.232

Low

756571

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.232

Low

756578

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.232

Low

756585

CNNM2
Metal transporter CNNM2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025