HitPredict

Interactor 1: VATL (P27449)
V-type proton ATPase 16 kDa proteolipid subunit c (V-ATPase 16 kDa proteolipid subunit c) (Vacuolar proton pump 16 kDa proteolipid subunit c)
Gene: ATP6V0C

Interactor 2: VPP2 (Q9Y487)
V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2)
Gene: ATP6V0A2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

The method score is based on:

Property	Details
Experiments	28514442, 33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	ATP-synt_C~V_ATPase_I
Common GO terms	GO:0000139 - Golgi membrane GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain GO:0005765 - lysosomal membrane GO:0005886 - plasma membrane GO:0005925 - focal adhesion and 9 others more... GO:0007035 - vacuolar acidification GO:0010008 - endosome membrane GO:0016241 - regulation of macroautophagy GO:0030670 - phagocytic vesicle membrane GO:0033176 - proton-transporting V-type ATPase complex GO:0046961 - proton-transporting ATPase activity, rotational mechanism GO:0061795 - Golgi lumen acidification GO:1902495 - transmembrane transporter complex GO:1902600 - proton transmembrane transport
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1	155
Hs

1	856

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024