HitPredict

Interactor 1: ARNT (P27540)
Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta)
Gene: ARNT

Interactor 2: NPAS3 (Q8IXF0)
Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Basic-helix-loop-helix-PAS protein MOP6) (Class E basic helix-loop-helix protein 12) (bHLHe12) (Member of PAS protein 6) (PAS domain-containing protein 6)
Gene: NPAS3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HLH~PAS, PAS~PAS, PAS~PAS_3, PAS~PAS_11, PAS_11~PAS_3
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0046982 - protein heterodimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 789 Hs			1 933
+	Mm
		101520 ARNT_MOUSE (1-789): 0: 637: 91.40		F8VQB2_MOUSE (4-933): 0: 904: 93.55
+	Hs
		649150 ARNT_HUMAN (1-789): 0: 649: 100.00		EPAS1_HUMAN (41-775): 1.97e-143: 449: 21.99
+	Hs
		649084 ARNT_HUMAN (1-789): 0: 649: 100.00		SIM1_HUMAN (53-693): 3.93e-143: 445: 30.95
+	Hs
		649033 ARNT_HUMAN (1-789): 0: 649: 100.00		ARNT_HUMAN (23-722): 1.89e-142: 444: 16.40
+	Mm
		864792 ARNT_MOUSE (1-789): 0: 637: 91.40		SIM1_MOUSE (53-757): 1.47e-141: 441: 28.83
+	Hs
		649106 ARNT_HUMAN (1-789): 0: 649: 100.00		SIM2_HUMAN (53-721): 1.08e-137: 428: 29.51
+	Hs
		649123 ARNT_HUMAN (1-789): 0: 649: 100.00		HIF1A_HUMAN (41-596): 8.69e-136: 428: 27.40
+	Mm
		864790 ARNT_MOUSE (1-789): 0: 637: 91.40		EPAS1_MOUSE (41-795): 2.21e-138: 436: 23.19
+	Hs
		181499 ARNT_HUMAN (1-789): 0: 649: 100.00		CLOCK_HUMAN (22-752): 7.58e-122: 392: 15.57
+	Hs
		649148 ARNT_HUMAN (1-789): 0: 649: 100.00		NPAS1_HUMAN (9-541): 1.86e-122: 386: 44.32
+	Hs
		649119 ARNT_HUMAN (1-789): 0: 649: 100.00		NCOA1_HUMAN (40-683): 6.47e-111: 375: 19.36
+	Mm
		864789 ARNT_MOUSE (1-789): 0: 637: 91.40		NPAS1_MOUSE (9-605): 7.41e-123: 387: 41.58
+	Hs
		649175 ARNT_HUMAN (1-789): 0: 649: 100.00		HIF3A_HUMAN (43-757): 4.2e-113: 363: 23.45
+	Hs
		649052 ARNT_HUMAN (1-789): 0: 649: 100.00		AHR_HUMAN (39-594): 2.43e-108: 356: 20.95
+	Hs
		649131 ARNT_HUMAN (1-789): 0: 649: 100.00		NPAS4_HUMAN (54-755): 6.06e-107: 351: 17.45
+	Hs
		649149 ARNT_HUMAN (1-789): 0: 649: 100.00		NPAS2_HUMAN (44-761): 2.07e-105: 348: 13.36
+	Hs
		69415 ARNT_HUMAN (1-789): 0: 649: 100.00		AHRR_HUMAN (28-723): 1.38e-106: 347: 17.02
+	Hs
		649117 ARNT_HUMAN (1-789): 0: 649: 100.00		NCOA2_HUMAN (31-737): 3e-99: 342: 15.35
+	Mm
		674910 ARNT_MOUSE (1-789): 0: 637: 91.40		AHR_MOUSE (39-602): 5.7e-106: 350: 20.35
+	Mm
		864791 ARNT_MOUSE (1-789): 0: 637: 91.40		AHRR_MOUSE (51-367): 5.01e-70: 248: 22.43