HitPredict

Interactor 1: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Interactor 2: MCM5 (P33992)
DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46)
Gene: MCM5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	20679368, 37827155
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0003697 - single-stranded DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006260 - DNA replication
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 616 Hs			1 734
+	Hs
		650666 RFA1_HUMAN (1-616): 0: 781: 100.00		MCM2_HUMAN (28-732): 0: 675: 30.09
+	Hs
		650487 RFA1_HUMAN (1-616): 0: 781: 100.00		MCM4_HUMAN (6-724): 0: 672: 30.20
+	Hs
		650489 RFA1_HUMAN (1-616): 0: 781: 100.00		MCM7_HUMAN (27-730): 0: 649: 27.57
+	Hs
		651202 RFA1_HUMAN (1-616): 0: 781: 100.00		MCM6_HUMAN (12-705): 0: 642: 27.41
+	Sc
		607223 RFA1_YEAST (4-615): 0: 596: 31.69		MCM5_YEAST (4-732): 0: 674: 46.34
+	Sc
		607222 RFA1_YEAST (4-615): 0: 596: 31.69		MCM2_YEAST (29-685): 0: 654: 32.24
+	Sc
		607309 RFA1_YEAST (4-615): 0: 596: 31.69		MCM6_YEAST (1-713): 0: 629: 25.63
+	Sc
		607261 RFA1_YEAST (4-615): 0: 596: 31.69		MCM7_YEAST (132-647): 1.22e-89: 300: 38.00