HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: ADA15 (Q13444)
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin)
Gene: ADAM15

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	11741929, 16374509, 25825872
Identification Methods	affinity chromatography technology, pull down, peptide array, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0045087 - innate immune response GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 509 Hs			1 863
+	Hs
		442824 HCK_HUMAN (1-509): 0: 602: 65.04		ADA15_HUMAN (1-863): 0: 556: 100.00
+	Hs
		412180 FYN_HUMAN (30-507): 0: 586: 59.01		ADA15_HUMAN (1-863): 0: 556: 100.00
+	Hs
		522964 SRC_HUMAN (20-507): 0: 586: 55.00		ADA15_HUMAN (1-863): 0: 556: 100.00
+	Hs
		433748 LYN_HUMAN (1-509): 0: 582: 62.72		ADA15_HUMAN (1-863): 0: 556: 100.00
+	Hs
		197581 HCK_HUMAN (1-509): 0: 602: 65.04		ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32
+	Hs
		442882 HCK_HUMAN (1-509): 0: 602: 65.04		ADA19_HUMAN (8-859): 3.95e-164: 504: 33.00
+	Hs
		197579 FYN_HUMAN (30-507): 0: 586: 59.01		ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32
+	Hs
		197583 SRC_HUMAN (20-507): 0: 586: 55.00		ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32
+	Hs
		433747 LYN_HUMAN (1-509): 0: 582: 62.72		ADAM9_HUMAN (31-823): 4.3e-168: 510: 31.00
+	Hs
		197580 LYN_HUMAN (1-509): 0: 582: 62.72		ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32
+	Hs
		523142 SRC_HUMAN (20-507): 0: 586: 55.00		ADA19_HUMAN (8-859): 3.95e-164: 504: 33.00
+	Hs
		433995 LYN_HUMAN (1-509): 0: 582: 62.72		ADA19_HUMAN (8-859): 3.95e-164: 504: 33.00
+	Hs
		522899 SRC_HUMAN (20-507): 0: 586: 55.00		ADAM8_HUMAN (1-851): 5.57e-160: 489: 31.26
+	Hs
		442890 HCK_HUMAN (1-509): 0: 602: 65.04		ADA22_HUMAN (7-698): 1.49e-136: 430: 27.98
+	Hs
		434044 LYN_HUMAN (1-509): 0: 582: 62.72		ADA22_HUMAN (7-698): 1.49e-136: 430: 27.98
+	Hs
		152227 LCK_HUMAN (1-509): 0: 661: 100.00		ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44
+	Hs
		152233 HCK_HUMAN (1-509): 0: 602: 65.04		ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44
+	Hs
		152228 FYN_HUMAN (30-507): 0: 586: 59.01		ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44
+	Hs
		152242 SRC_HUMAN (20-507): 0: 586: 55.00		ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44
+	Hs
		522906 SRC_HUMAN (20-507): 0: 586: 55.00		ADA17_HUMAN (348-534): 2.91e-20: 98.6: 32.29