HitPredict

Interactor 1: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Interactor 2: RFC1 (P35251)
Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit)
Gene: RFC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	26474068, 37827155, 24332808
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006261 - DNA-templated DNA replication GO:0006281 - DNA repair GO:0007004 - telomere maintenance via telomerase
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 616 Hs			1 1148
+	Hs
		651784 RFA1_HUMAN (1-616): 0: 781: 100.00		CTF18_HUMAN (293-1131): 2.29e-93: 323: 15.11
+	Hs
		650525 RFA1_HUMAN (1-616): 0: 781: 100.00		LONM_HUMAN (275-1000): 2.34e-69: 253: 9.59
+	Hs
		650501 RFA1_HUMAN (1-616): 0: 781: 100.00		RFC4_HUMAN (557-927): 1.06e-72: 248: 19.47
+	Dm
		725322 RFA1_DROME (1-614): 0: 619: 41.00		RFC1_DROME (175-1127): 2.34e-119: 395: 38.93
+	Hs
		650557 RFA1_HUMAN (1-616): 0: 781: 100.00		RFC5_HUMAN (565-913): 8.86e-65: 225: 19.22
+	Hs
		651488 RFA1_HUMAN (1-616): 0: 781: 100.00		FIGL1_HUMAN (247-875): 3.1e-61: 224: 12.50
+	Hs
		650502 RFA1_HUMAN (1-616): 0: 781: 100.00		RFC2_HUMAN (561-915): 3.38e-62: 218: 18.26
+	Hs
		652006 RFA1_HUMAN (1-616): 0: 781: 100.00		ATAD5_HUMAN (494-707): 4.08e-36: 151: 25.96