HitPredict

Interactor 1: ROA2 (P22626)
Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1)
Gene: HNRNPA2B1

Interactor 2: RA1L2 (Q32P51)
Heterogeneous nuclear ribonucleoprotein A1-like 2 (hnRNP A1-like 2) (hnRNP core protein A1-like 2)
Gene: HNRNPA1L2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.839

Property	Details
Experiments	30021884, 35575683, 38334954
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HnRNPA1_LC~HnRNPA1_LC, RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005737 - cytoplasm GO:0051028 - mRNA transport GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 353 Hs			1 320
+	Hs
		172188 HNRDL_HUMAN (12-292): 9.85e-66: 215: 33.45		ROAA_HUMAN (3-276): 1.34e-67: 216: 34.75
+	Hs
		172120 HNRDL_HUMAN (12-292): 9.85e-66: 215: 33.45		RA1L2_HUMAN (1-320): 2.35e-66: 212: 100.00
+	Hs
		650924 ROA2_HUMAN (1-353): 7.92e-64: 208: 100.00		ROAA_HUMAN (3-276): 1.34e-67: 216: 34.75
+	Hs
		171995 HNRDL_HUMAN (12-292): 9.85e-66: 215: 33.45		ROA1_HUMAN (1-188): 1.66e-53: 181: 97.34
+	Hs
		484918 ROA2_HUMAN (1-353): 7.92e-64: 208: 100.00		ROA1_HUMAN (1-188): 1.66e-53: 181: 97.34
+	Hs
		172001 HNRDL_HUMAN (12-292): 9.85e-66: 215: 33.45		PABP1_HUMAN (1-193): 5.19e-42: 155: 18.56
+	Hs
		550120 ROA2_HUMAN (1-353): 7.92e-64: 208: 100.00		PABP1_HUMAN (1-193): 5.19e-42: 155: 18.56
+	Hs
		650657 ROA2_HUMAN (1-353): 7.92e-64: 208: 100.00		ROA3_HUMAN (96-192): 7.01e-21: 93.6: 26.80
+	Hs
		650730 ROA2_HUMAN (1-353): 7.92e-64: 208: 100.00		ROA0_HUMAN (4-94): 4.65e-20: 90.5: 36.26
+	Hs
		172102 HNRDL_HUMAN (12-292): 9.85e-66: 215: 33.45		HNRPD_HUMAN (3-101): 5.99e-17: 82.4: 31.31
+	Hs
		172092 HNRDL_HUMAN (12-292): 9.85e-66: 215: 33.45		PABP4_HUMAN (102-188): 2.57e-16: 81.2: 17.05
+	Hs
		172016 HNRDL_HUMAN (12-292): 9.85e-66: 215: 33.45		ROA2_HUMAN (3-97): 2.32e-15: 77.8: 31.58
+	Hs
		650751 ROA2_HUMAN (1-353): 7.92e-64: 208: 100.00		HNRPD_HUMAN (3-101): 5.99e-17: 82.4: 31.31
+	Hs
		214259 MSI1H_HUMAN (3-341): 3.22e-62: 204: 28.77		MSI1H_HUMAN (3-107): 3.12e-17: 83.2: 34.29
+	Mm
		1222783 MSI1H_MOUSE (3-341): 1.09e-61: 203: 28.77		MSI1H_MOUSE (3-280): 4.21e-17: 82.8: 20.50
+	Hs
		650596 ROA2_HUMAN (1-353): 7.92e-64: 208: 100.00		ROA2_HUMAN (3-97): 2.32e-15: 77.8: 31.58
+	Hs
		214326 MSI1H_HUMAN (3-341): 3.22e-62: 204: 28.77		MSI2H_HUMAN (3-130): 1.13e-15: 78.2: 27.34
+	Hs
		1387459 MSI2H_HUMAN (1-341): 2.05e-56: 188: 28.15		MSI2H_HUMAN (3-130): 1.13e-15: 78.2: 27.34