HitPredict

Interactor 1: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	34348893
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 616 Hs			1 217
+	Hs
		650563 RFA1_HUMAN (1-616): 0: 781: 100.00		CSK_HUMAN (2-139): 3.92e-24: 100: 36.24
+	Hs
		433262 RFA1_HUMAN (1-616): 0: 781: 100.00		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		433593 RFA1_HUMAN (1-616): 0: 781: 100.00		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		522794 RFA1_HUMAN (1-616): 0: 781: 100.00		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		650740 RFA1_HUMAN (1-616): 0: 781: 100.00		VAV2_HUMAN (3-56): 4.83e-11: 63.5: 38.18