HitPredict

Interactor 1: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Interactor 2: HERC1 (Q15751)
Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619)
Gene: HERC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	37827155
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 616 Hs			1 4861
+	Hs
		650616 RFA1_HUMAN (1-616): 0: 781: 100.00		NEDD4_HUMAN (4360-4841): 3.39e-153: 517: 20.97
+	Hs
		651966 RFA1_HUMAN (1-616): 0: 781: 100.00		ITCH_HUMAN (4369-4843): 2.48e-157: 516: 23.03
+	Hs
		651570 RFA1_HUMAN (1-616): 0: 781: 100.00		HUWE1_HUMAN (4372-4842): 8.91e-133: 474: 21.86
+	Hs
		651016 RFA1_HUMAN (1-616): 0: 781: 100.00		UBE3A_HUMAN (4457-4842): 3.46e-126: 424: 25.96
+	Hs
		652547 RFA1_HUMAN (1-616): 0: 781: 100.00		HERC5_HUMAN (260-456): 3.06e-31: 137: 14.00
+	Hs
		319724 RFA1_HUMAN (1-616): 0: 781: 100.00		HERC2_HUMAN (593-845): 9.55e-10: 67.8: 15.81
+	Sc
		607329 RFA1_YEAST (4-615): 0: 596: 31.69		TOM1_YEAST (4513-4835): 7.49e-36: 154: 30.30
+	Hs
		1235435 MEIOB_HUMAN (176-543): 7.11e-63: 216: 16.10		HECW2_HUMAN (4408-4843): 6.03e-133: 463: 24.50
+	Hs
		319880 RADX_HUMAN (27-384): 6.8e-66: 233: 16.24		HERC2_HUMAN (593-845): 9.55e-10: 67.8: 15.81