HitPredict

Interactor 1: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Interactor 2: MACD1 (Q9BQ69)
ADP-ribose glycohydrolase MACROD1 (MACRO domain-containing protein 1) (O-acetyl-ADP-ribose deacetylase MACROD1) (EC 3.1.1.106) (Protein LRP16) ([Protein ADP-ribosylaspartate] hydrolase MACROD1) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD1) (EC 3.2.2.-)
Gene: MACROD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	28514442, 37827155
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 616 Hs			1 325
+	Hs
		260761 RFA1_HUMAN (1-616): 0: 781: 100.00		H2AY_HUMAN (121-314): 1.57e-51: 176: 22.11
+	Hs
		652467 RFA1_HUMAN (1-616): 0: 781: 100.00		H2AW_HUMAN (131-314): 4.06e-45: 159: 19.70
+	Hs
		651640 RFA1_HUMAN (1-616): 0: 781: 100.00		PARP9_HUMAN (80-320): 1.65e-41: 155: 20.33
+	Hs
		651357 RFA1_HUMAN (1-616): 0: 781: 100.00		PAR14_HUMAN (123-314): 9.87e-23: 100: 24.62