HitPredict

Interactor 1: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Interactor 2: UBE2O (Q9C0C9)
(E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O)
Gene: UBE2O

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	36273042, 37827155
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 616 Hs			1 1292
+	Hs
		652343 RFA1_HUMAN (1-616): 0: 781: 100.00		BIRC6_HUMAN (670-1224): 6.17e-75: 277: 20.03
+	Hs
		651334 RFA1_HUMAN (1-616): 0: 781: 100.00		UBE2S_HUMAN (942-1108): 1.64e-49: 177: 27.55
+	Hs
		650837 RFA1_HUMAN (1-616): 0: 781: 100.00		UBE2N_HUMAN (956-1103): 1.44e-45: 163: 22.52
+	Sc
		607325 RFA1_YEAST (4-615): 0: 596: 31.69		UBC7_YEAST (951-1076): 3.09e-42: 153: 28.57