HitPredict

Interactor 1: APEX1 (P27695)
DNA repair nuclease/redox regulator APEX1 (EC 3.1.11.2) (EC 3.1.21.-) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (DNA-(apurinic or apyrimidinic site) endonuclease) (Redox factor-1) (REF-1) [Cleaved into: DNA repair nuclease/redox regulator APEX1, mitochondrial]
Gene: APEX1

Interactor 2: SETD2 (Q9BYW2)
Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP)
Gene: SETD2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0046872 - metal ion binding
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 318 Hs			1 2564
+	Hs
		331726 APEX1_HUMAN (1-318): 4.45e-170: 476: 100.00		NSD2_HUMAN (1441-1728): 1.87e-77: 287: 34.45
+	Hs
		652982 APEX1_HUMAN (1-318): 4.45e-170: 476: 100.00		NSD3_HUMAN (1410-1728): 2.45e-77: 287: 31.33
+	Hs
		652959 APEX1_HUMAN (1-318): 4.45e-170: 476: 100.00		NSD1_HUMAN (1458-1727): 5.38e-73: 275: 32.73
+	Hs
		652995 APEX1_HUMAN (1-318): 4.45e-170: 476: 100.00		EHMT1_HUMAN (1432-1726): 8.57e-72: 268: 24.38