Protein: MSX2
Homeobox protein MSX-2 (Homeobox protein Hox-8)

Gene: MSX2
Organism: Homo sapiens
Interactions: 186
UniProt ID: P35548

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

224944

TLX3
T-cell leukemia homeobox protein 3

2

20

High-throughput

0.783

High

478904

PO2F2
POU domain, class 2, transcription factor 2

2

20

High-throughput

0.783

High

700815

PIT1
Pituitary-specific positive transcription factor 1

2

20

High-throughput

0.783

High

725129

HXC9
Homeobox protein Hox-C9

2

20

High-throughput

0.783

High

772141

PITX1
Pituitary homeobox 1

2

19

High-throughput

0.783

High

772142

PO6F2
POU domain, class 6, transcription factor 2

2

20

High-throughput

0.783

High

772167

ZFHX3
Zinc finger homeobox protein 3

2

10

High-throughput

0.783

High

772199

RHXF2
Rhox homeobox family member 2

2

20

High-throughput

0.783

High

703262

MSX1
Homeobox protein MSX-1

1

20

Small-scale

0.680

High

772205

ZN703
Zinc finger protein 703

3

13

High-throughput

0.667

High

772217

HBS1L
HBS1-like protein

3

4

High-throughput

0.667

High

772100

MSX2
Homeobox protein MSX-2

1

18

Small-scale

0.647

High

772120

DLX5
Homeobox protein DLX-5

1

20

Small-scale

0.647

High

772153

DLX2
Homeobox protein DLX-2

1

20

Small-scale

0.647

High

181782

EPHB6
Ephrin type-B receptor 6

2

3

High-throughput

0.606

High

288071

FOXH1
Forkhead box protein H1

2

20

High-throughput

0.606

High

348852

CLIC3
Chloride intracellular channel protein 3

2

1

High-throughput

0.606

High

662381

GATA2
Endothelial transcription factor GATA-2

2

12

High-throughput

0.606

High

703461

MK01
Mitogen-activated protein kinase 1

2

3

High-throughput

0.606

High

772101

SOX5
Transcription factor SOX-5

2

20

High-throughput

0.606

High

772154

TLE5
TLE family member 5

2

20

High-throughput

0.606

High

772160

VEZF1
Vascular endothelial zinc finger 1

2

3

High-throughput

0.606

High

772173

RBPS2
RNA-binding protein with multiple splicing 2

2

3

High-throughput

0.606

High

772181

SMAP2
Stromal membrane-associated protein 2

2

1

High-throughput

0.606

High

772194

LENG8
Leukocyte receptor cluster member 8

2

6

High-throughput

0.606

High

772206

PATZ1
POZ-, AT hook-, and zinc finger-containing protein 1

2

2

High-throughput

0.606

High

772208

TF7L2
Transcription factor 7-like 2

2

20

High-throughput

0.606

High

772147

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

3

8

High-throughput

0.596

High

772188

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

2

0

High-throughput

0.580

High

772189

ZC3HA
Zinc finger CCCH domain-containing protein 10

2

0

High-throughput

0.580

High

772203

TOLIP
Toll-interacting protein

2

0

High-throughput

0.580

High

772210

PRR13
Proline-rich protein 13

2

0

High-throughput

0.580

High

772214

FBXW2
F-box/WD repeat-containing protein 2

1

5

Small-scale

0.561

High

772171

C102B
Coiled-coil domain-containing protein 102B

2

1

High-throughput

0.553

High

772178

MISSL
MAPK-interacting and spindle-stabilizing protein-like

2

3

High-throughput

0.553

High

772193

TSSK3
Testis-specific serine/threonine-protein kinase 3

2

1

High-throughput

0.553

High

772202

YTHD1
YTH domain-containing family protein 1

2

3

High-throughput

0.553

High

403872

GCR
Glucocorticoid receptor

1

13

High-throughput

0.541

High

772102

PPARG
Peroxisome proliferator-activated receptor gamma

1

14

High-throughput

0.541

High

772117

ATX1
Ataxin-1

1

5

High-throughput

0.541

High

772150

TLE1
Transducin-like enhancer protein 1

1

20

High-throughput

0.541

High

772151

TLE2
Transducin-like enhancer protein 2

1

20

High-throughput

0.541

High

297763

PIAS2
E3 SUMO-protein ligase PIAS2

1

4

Small-scale

0.527

High

430613

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

High-throughput

0.518

High

772107

HD
Huntingtin

1

3

High-throughput

0.515

High

772174

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

8

High-throughput

0.515

High

772111

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

Small-scale

0.501

High

772213

ZDHC2
Palmitoyltransferase ZDHHC2

1

3

High-throughput

0.494

High

569068

T2FB
General transcription factor IIF subunit 2

1

0

Small-scale

0.480

High

770344

T2FA
General transcription factor IIF subunit 1

1

0

Small-scale

0.480

High

165276

PSA7
Proteasome subunit alpha type-7

1

2

High-throughput

0.479

High

358626

LDHA
L-lactate dehydrogenase A chain

1

2

High-throughput

0.479

High

395600

ESR1
Estrogen receptor

1

16

High-throughput

0.479

High

402536

ALDOA
Fructose-bisphosphate aldolase A

1

1

High-throughput

0.479

High

450937

LDHB
L-lactate dehydrogenase B chain

1

2

High-throughput

0.479

High

456635

ANXA2
Annexin A2

1

1

High-throughput

0.479

High

462268

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

3

High-throughput

0.479

High

468127

HS90B
Heat shock protein HSP 90-beta

1

4

High-throughput

0.479

High

474517

VIME
Vimentin

1

5

High-throughput

0.479

High

481126

HMGB1
High mobility group protein B1

1

20

High-throughput

0.479

High

484959

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

High-throughput

0.479

High

487021

PARP1
Poly [ADP-ribose] polymerase 1

1

6

High-throughput

0.479

High

521566

H14
Histone H1.4

1

5

High-throughput

0.479

High

536321

MTAP2
Microtubule-associated protein 2

1

9

High-throughput

0.479

High

550145

PABP1
Polyadenylate-binding protein 1

1

2

High-throughput

0.479

High

553132

KCRB
Creatine kinase B-type

1

1

High-throughput

0.479

High

557899

XRCC6
X-ray repair cross-complementing protein 6

1

8

Small-scale

0.479

High

559244

XRCC5
X-ray repair cross-complementing protein 5

1

8

Small-scale

0.479

High

568206

PLST
Plastin-3

1

1

High-throughput

0.479

High

573014

KPYM
Pyruvate kinase PKM

1

2

High-throughput

0.479

High

573356

ENPL
Endoplasmin

1

4

High-throughput

0.479

High

587574

DESP
Desmoplakin

1

4

High-throughput

0.479

High

595328

H15
Histone H1.5

1

5

High-throughput

0.479

High

636823

GSTM3
Glutathione S-transferase Mu 3

1

1

High-throughput

0.479

High

637125

CSRP1
Cysteine and glycine-rich protein 1

1

4

High-throughput

0.479

High

687339

PTBP1
Polypyrimidine tract-binding protein 1

1

3

High-throughput

0.479

High

687907

EF1G
Elongation factor 1-gamma

1

1

High-throughput

0.479

High

715456

MARCS
Myristoylated alanine-rich C-kinase substrate

1

3

High-throughput

0.479

High

771858

CBS
Cystathionine beta-synthase

1

1

High-throughput

0.479

High

772103

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

772104

MDHC
Malate dehydrogenase, cytoplasmic

1

2

High-throughput

0.479

High

772106

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.479

High

772108

RS5
Small ribosomal subunit protein uS7

1

2

High-throughput

0.479

High

772109

NASP
Nuclear autoantigenic sperm protein

1

3

High-throughput

0.479

High

772110

SYSC
Serine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

772112

RBM25
RNA-binding protein 25

1

5

High-throughput

0.479

High

772113

DHB4
Peroxisomal multifunctional enzyme type 2

1

1

High-throughput

0.479

High

772121

MTPN
Myotrophin

1

10

High-throughput

0.479

High

772122

H2B1D
Histone H2B type 1-D

1

2

High-throughput

0.479

High

772126

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

4

High-throughput

0.479

High

772128

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.479

High

772132

RS24
Small ribosomal subunit protein eS24

1

1

High-throughput

0.479

High

772137

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

1

2

High-throughput

0.479

High

772138

1433Z
14-3-3 protein zeta/delta

1

3

High-throughput

0.479

High

772140

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

4

High-throughput

0.479

High

772144

BASP1
Brain acid soluble protein 1

1

2

High-throughput

0.479

High

772145

FKBP3
Peptidyl-prolyl cis-trans isomerase FKBP3

1

2

High-throughput

0.479

High

772149

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

3

High-throughput

0.479

High

772155

DHX9
ATP-dependent RNA helicase A

1

2

High-throughput

0.479

High

772156

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

7

High-throughput

0.479

High

772157

GOGA4
Golgin subfamily A member 4

1

2

High-throughput

0.479

High

772159

RUNX2
Runt-related transcription factor 2

1

2

Small-scale

0.479

High

772161

GOGB1
Golgin subfamily B member 1

1

3

High-throughput

0.479

High

772162

SF3A1
Splicing factor 3A subunit 1

1

9

High-throughput

0.479

High

772164

PCH2
Pachytene checkpoint protein 2 homolog

1

1

High-throughput

0.479

High

772166

NEDD8
Ubiquitin-like protein NEDD8

1

1

High-throughput

0.479

High

772177

FA98A
Protein FAM98A

1

1

High-throughput

0.479

High

772184

SMRC1
SWI/SNF complex subunit SMARCC1

1

15

High-throughput

0.479

High

772185

RNF34
E3 ubiquitin-protein ligase RNF34

1

1

High-throughput

0.479

High

772192

TIGD1
Tigger transposable element-derived protein 1

1

2

High-throughput

0.479

High

772196

RSF1
Remodeling and spacing factor 1

1

20

High-throughput

0.479

High

772198

TBA1C
Tubulin alpha-1C chain

1

1

High-throughput

0.479

High

772201

SRBS1
Sorbin and SH3 domain-containing protein 1

1

4

High-throughput

0.479

High

772207

SEC12
Guanine nucleotide-exchange factor SEC12

1

1

High-throughput

0.479

High

772209

DDX21
Nucleolar RNA helicase 2

1

2

High-throughput

0.479

High

772211

CLIP2
CAP-Gly domain-containing linker protein 2

1

4

High-throughput

0.479

High

772218

SERC
Phosphoserine aminotransferase

1

1

High-throughput

0.479

High

109373

G5E9A7
DM1 locus, WD repeat containing

1

7

High-throughput

0.470

High

295297

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.458

High

365316

PGK1
Phosphoglycerate kinase 1

1

0

High-throughput

0.458

High

424364

HMGN1
Non-histone chromosomal protein HMG-14

1

0

High-throughput

0.458

High

443688

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

0

High-throughput

0.458

High

457264

TBB5
Tubulin beta chain

1

0

High-throughput

0.458

High

469265

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

0

High-throughput

0.458

High

551694

HARS1
Histidine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

562997

MYH6
Myosin-6

1

0

High-throughput

0.458

High

591236

CD44
CD44 antigen

1

0

High-throughput

0.458

High

601580

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.458

High

612524

RL7
Large ribosomal subunit protein uL30

1

0

High-throughput

0.458

High

646773

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

658001

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

716769

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.458

High

721138

SORCN
Sorcin

1

0

High-throughput

0.458

High

772105

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

772114

GDIR1
Rho GDP-dissociation inhibitor 1

1

0

High-throughput

0.458

High

772115

RIDA
2-iminobutanoate/2-iminopropanoate deaminase

1

0

High-throughput

0.458

High

772116

ACLY
ATP-citrate synthase

1

0

High-throughput

0.458

High

772118

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

772119

MANF
Mesencephalic astrocyte-derived neurotrophic factor

1

0

High-throughput

0.458

High

772123

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.458

High

772124

RL27
Large ribosomal subunit protein eL27

1

0

High-throughput

0.458

High

772125

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

772127

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.458

High

772129

RS18
Small ribosomal subunit protein uS13

1

0

High-throughput

0.458

High

772130

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.458

High

772131

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

0

High-throughput

0.458

High

772133

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.458

High

772134

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

772135

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.458

High

772136

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.458

High

772139

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.458

High

772143

MT1X
Metallothionein-1X

1

0

High-throughput

0.458

High

772146

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

0

High-throughput

0.458

High

772152

PRDX1
Peroxiredoxin-1

1

0

High-throughput

0.458

High

772158

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.458

High

772163

TSN
Translin

1

0

High-throughput

0.458

High

772165

HMGN3
High mobility group nucleosome-binding domain-containing protein 3

1

0

High-throughput

0.458

High

772176

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

772180

DTD1
D-aminoacyl-tRNA deacylase 1

1

0

High-throughput

0.458

High

772183

H1X
Histone H1.10

1

0

High-throughput

0.458

High

772186

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.458

High

772195

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.458

High

772197

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

0

High-throughput

0.458

High

772200

PYM1
Partner of Y14 and mago

1

0

High-throughput

0.458

High

772204

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

0

High-throughput

0.458

High

772216

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.458

High

772169

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

1

1

High-throughput

0.439

High

458631

PGS2
Decorin

1

2

High-throughput

0.437

High

705257

GRN
Progranulin

1

4

High-throughput

0.437

High

772170

STYL2
Serine/threonine/tyrosine-interacting-like protein 2

1

4

High-throughput

0.437

High

772187

LRC59
Leucine-rich repeat-containing protein 59

1

3

High-throughput

0.437

High

772190

DNJC1
DnaJ homolog subfamily C member 1

1

4

High-throughput

0.437

High

772191

CFA44
Cilia- and flagella-associated protein 44

1

2

High-throughput

0.437

High

772172

ANR40
Ankyrin repeat domain-containing protein 40

2

0

High-throughput

0.328

High

772179

TET5D
Terminal nucleotidyltransferase 5D

2

0

High-throughput

0.316

High

772168

OBF1
POU domain class 2-associating factor 1

1

0

High-throughput

0.282

High

772175

Q86WV8
TSC complex subunit 1

1

0

High-throughput

0.268

Low

220680

DENR
Density-regulated protein

1

0

High-throughput

0.249

Low

420400

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.249

Low

506815

TB15B
Thymosin beta-15B

1

0

High-throughput

0.249

Low

636708

PTN
Pleiotrophin

1

0

High-throughput

0.249

Low

772148

TAGL
Transgelin

1

0

High-throughput

0.249

Low

772182

TM263
Transmembrane protein 263

1

0

High-throughput

0.249

Low

772212

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

0

High-throughput

0.249

Low

772215

TMA7
Translation machinery-associated protein 7

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025